Nallathambi Sengottuvelan

Synthesis, interactions, molecular structure, biological properties and molecular docking studies on Mn, Co, Zn complexes containing acetylacetone and pyridine ligands with DNA duplex.

Three metal complexes (1-3) of the type [Mn(acac)2(py)·H2O] (1), [Co(acac)2(py)·H2O] (2) and [Zn(acac)2(py)·H2O] (3), [Where acac=acetylacetone, py=pyridine] were synthesized and characterized by spectral (UV-vis, FT-IR, ESI-mass) analysis. The structure of complex 2 has been determined by single crystal X-ray diffraction studies and the configuration of ligand-coordinated to metal(II) ion was well described as distorted octahedral coordination geometry. The interaction of the complexes with CT-DNA has been explored by absorption, fluorescence, circular dichromism spectroscopy, viscosity measurements and molecular docking studies. The intrinsic binding constant Kb of complexes 1-3 with CT-DNA obtained from UV-vis absorption spectral studies were 2.1×10(4), 2.1×10(5) and 1.98×10(4)M(-1), respectively, which revealed that the complexes could interact with CT-DNA through groove binding. The results indicated that the complexes (1-3) were able to bind to DNA with different binding affinity, in the order: 2>1>3. The interaction of the compounds with bovine serum albumins were also investigated using fluorescence methods and the gel electrophoresis assay demonstrates weak cleavage ability of the pBR322 plasmid DNA in the presence of the metal complexes (1-3) with various activators. Further, the in vitro cytotoxic effect of the complexes were examined on cancerous cell line, with human breast cancer cells MCF-7.

Electrochemical synthesis of nitrogen-doped carbon quantum dots decorated copper oxide for the sensitive and selective detection of non-steroidal anti-inflammatory drug in berries

We report a sensitive non-steroidal anti-inflammatory drug aspirin (ASA) sensor studies using the nitrogen-doped carbon quantum dots (N-CQD) decorated copper oxide (Cu2O). A simplistic approach of electrochemical deposition method has been used to prepare the N-CQD incorporated with copper oxide (N-CQD/Cu2O) and the resulting composite has characterized by analytical techniques. Modified glassy carbon electrode of N-CQD/Cu2O/GCE is developed and is used for the sensor studies of aspirin. The modified N-CQD/Cu2O/GCE has exhibited a higher current (Ipa) response to the oxidation process when compared to N-CQD/GCE, Cu2O/GCE and bare GCE. Furthermore, it has shown a good linear range of 1-907 µM with a limit of detection (LOD) ∼0.002 µM and sensitivity ∼21.87 µA µM-1 cm-2. The developed sensor has displayed outstanding repeatability, stability and accumulation time along with better electro-catalytic response in berries for real-life application.

Hetero-metallic trigonal cage-shaped dimeric Ni3K core complex of L-proline ligand: Synthesis, structural, electrochemical and DNA binding and cleavage activities

AbstractHetero-metallic trigonal cage-shaped dimeric Ni3K core complex of L-proline ligand has been synthesized and characterized. Single crystal X-ray diffraction analysis showed that the hetero-metallic Ni(II)–K(I) complex has a dimeric structure with nine coordinated potassium atoms and six coordinated nickel atoms. The cyclic voltammograms of the complex exhibited two successive quasireversible reduction waves at (Epc1=−

6-Chloro-2-(4-meth-oxy-phen-yl)-4-phenyl-quinoline.

E_{\text {pc}}^{1} = -

Di-μ-hydroxido-κ(4) O:O-di-μ-perchlorato-κ(4) O:O'-bis-[(2,2'-bi-pyridine-κ(2) N,N')copper(II)].

1.02 V and Epc2=−

1,2-Bis(2-hy­droxy-5-methyl­benzyl­idene)hydrazine

E_{\text {pc}}^{2} = -

2-Hy­droxy-3-meth­oxy­methyl-5-methyl­benzaldehyde

1.33 V) and two successive irreversible oxidation waves (Epa1=

Synthesis, molecular structure, biological properties and molecular docking studies on Mn(II), Co(II) and Zn(II) complexes containing bipyridine-azide ligands.

E_{\text {pa}}^{1} =

Structural and Magnetic Properties of Monomeric and Dimeric Copper(II) Complexes with Phenyl-N-[(pyridine-2-yl)methylene]methaneamide

0.95 V and Epa2=

Synthesis of mononuclear copper(II) complexes of acyclic Schiff's base ligands: spectral, structural, electrochemical, antibacterial, DNA binding and cleavage activity.

E_{\text {pa}}^{2} =