Naoki Ishibashi
Astellas Pharma
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Publication
Featured researches published by Naoki Ishibashi.
Bioorganic & Medicinal Chemistry Letters | 2011
Kenichi Onda; Fumie Narazaki; Naoki Ishibashi; Keita Nakanishi; Yuki Sawada; Kenichiro Imamura; Kazuhiro Momose; Shigetada Furukawa; Yoshiaki Shimada; Hiroyuki Moriguchi; Masamichi Yuda; Hiroshi Kayakiri; Mitsuaki Ohta
Oxidative stress is widely recognized as being associated with a number of disorders, including metabolic dysfunction and atherosclerosis. A series of substituted 4-quinolone derivatives were prepared and evaluated as inhibitors of reactive oxygen species (ROS) production from human umbilical vein endothelial cells (HUVECs). One compound in particular, 2-({[4-(3-hydroxy-3-methylbutoxy)pyridin-2-yl]oxy}methyl)-3-methylquinolin-4(1H)-one (25b), inhibited ROS production from HUVECs with an IC(50) of 140 nM. This compound also exhibited low CYP2D6 inhibitory activity, high aqueous solubility, and good in vitro metabolic stability. An in vivo pharmacokinetic study of this compound in SD rats revealed high oral bioavailability and a long plasma half-life.
Archive | 2004
Naoki Ishibashi; Kazunori Kamijo; Shigeki Fujisawa Pharmaceutical Co. Ltd. Satoh; Yasuharu Urano
Archive | 1999
Hiroshi Kayakiri; Yoshito Abe; Hitoshi Hamashima; Hitoshi Sawada; Naoki Ishibashi; Hiroyuki Setoi; Noritsugu Yamasaki; Takafumi Imoto; Takahiro Hiramura; Teruo Oku
Archive | 2005
Naoki Ishibashi; Yuki Sawada; Yasuharu Urano; Shigeki Satoh; Yoshikazu Inoue; Yoshiteru Eikyu; Koichiro Mukoyoshi; Kazunori Kamijo; Fumiyuki Shirai; Hisashi Takasugi
Archive | 1999
Hiroshi Kayakiri; Yoshito Abe; Hitoshi Hamashima; Hitoshi Sawada; Naoki Ishibashi; Hiroyuki Setoi; Noritsugu Yamasaki; Takafumi Imoto; Takahiro Hiramura; Teruo Oku
Archive | 2002
Ichiro Shima; Takehiko Ohkawa; Kazuhiko Ohne; Kentaro Sato; Naoki Ishibashi; Kenichiro Imamura
Archive | 2002
Masahiro Neya; Akihiko Sawada; Kazuhiko Ohne; Yoshito Abe; Tsuyoshi Mizutani; Naoki Ishibashi; Makoto Inoue
Archive | 2008
Kenichi Onda; Kenichiro Imamura; Fumie Sato; Hiroyuki Moritomo; Yasuharu Urano; Yuki Sawada; Naoki Ishibashi; Keita Nakanishi; Kazuhiro Yokoyama; Shigetada Furukawa; Kazuhiro Momose
Archive | 2007
Takeshi Kato; Takayuki Suzuki; Kenichi Onda; Masakazu Imamura; Keita Nakanishi; Takanori Koike; Mitsuaki Okumura; Naoki Ishibashi; Masanori Yokono; Ichiro Takase; Takahiro Hiramura
Archive | 2005
Naoki Ishibashi; Yuki Sawada; Yasuharu Urano; Shigeki Satoh; Yoshikazu Inoue; Yoshiteru Eikyu; Koichiro Mukoyoshi; Kazunori Kamijo; Fumiyuki Shirai; Hisashi Takasugi
