Natalia Bellostas
University of Copenhagen
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Publication
Featured researches published by Natalia Bellostas.
Journal of Natural Products | 2008
Natalia Bellostas; Anne Dorthe Sørensen; Jens Christian Sørensen; Hilmer Sørensen
The ratio of isothiocyanates to nitriles formed upon the hydrolysis of glucosinolates is a key factor determining the physiological effect of glucosinolate-containing plants and materials. A micellar electrokinetic capillary chromatography (MECC) method was used to study the nonenzymatic Fe2+-catalyzed transformation of glucosinolates. At room temperature, pH 5, and in the presence of only 2 molar excess of Fe2+ all glucosinolate was degraded in 24 h. At all molar excess Fe2+ tested, nitriles were the major compounds formed. Thionamides were also formed from glucosinolates that contained a side chain hydroxylated at C-2; in this case, trace amounts of oxazolidine-2-thione were also detected. The presence of Fe3+ had no effect. The nonenzymatic Fe2+-catalyzed transformation of glucosinolates involves the binding of Fe2+ to the glucosinolate to form a complex.
Advances in Botanical Research | 2007
Natalia Bellostas; Anne Dorthe Sørensen; Jens Christian Sørensen; Hilmer Sørensen
Progress in the production and utilisation of oilseed rape (Brassica napus L. and B. rapa L.) and their derived products in the past years has resulted in the production of high‐yielding double low varieties with low levels of erucic acid and glucosinolates. In order to meet this objective, extensive knowledge on the occurrence, structure and properties of glucosinolates and myrosinase isoenzymes (thioglucohydrolase; EC 3.2.1.147) co‐occurring with glucosinolates is essential. The present chapter focusses on these subjects including heredity, genetic variation and metabolism of glucosinolates. A number of stages in the glucosinolate biosynthetic pathway are well known, but significant elements still remain to be further explored and elucidated. In recent years, most research has been confined on gene technology using Arabidopsis thaliana as a model and hence considering only the glucosinolates present in this particular plant. To date, more than 140 structurally different glucosinolates have been described of which ∼30 glucosinolates occur in Brassica species. Only relatively few glucosinolates are produced in individual plant genera and/or families. Knowledge on the genetic‐ and metabolic‐based regulation of glucosinolate accumulation in different plants is therefore of great relevance in order to explain the reasons for the chemotaxonomically limited occurrence of structurally different glucosinolates. The metabolic regulation and thus the biological consequences of those changes are however unknown. Similarly, the reasons for the high selectivity of the multi‐enzyme complexes towards the precursor amino acids in the biosynthesis of glucosinolates, as well as the specificity of the various enzymes needed for the modification of glucosinolate side chains and the substitution/esterification of the thioglucose residue of the molecules are yet to be clarified. The glucosinolate catabolism, which comprises the transformation of glucosinolates into various bioactive products, is another important area where limited information is available on the oligomeric myrosinase isoenzymes and associated compounds. This is especially relevant regarding the differences in the catalytic properties of the individual isoenzymes as well as the opportunities to modify these properties. New analytical methods allow for the synchronous detection of substrate and products in myrosinase‐catalysed reactions, which broadens the perspectives for progress in this field.
Scientia Horticulturae | 2007
Natalia Bellostas; Piotr Kachlicki; Jens Christian Sørensen; Hilmer Sørensen
Journal of the Science of Food and Agriculture | 2007
Natalia Bellostas; Jens Christian Sørensen; Hilmer Sørensen
Journal of Biochemical and Biophysical Methods | 2008
Natalia Bellostas; Iben Lykke Petersen; Jens Christian Sørensen; Hilmer Sørensen
Journal of Chromatography A | 2006
Natalia Bellostas; Jens Christian Sørensen; Hilmer Sørensen
African Journal of Agricultural Research | 2010
Natalia Bellostas; Jens Christian Sørensen; Albert Nikiema; Hilmer Sørensen; Sanjeet Kumar
Archive | 2007
Christian Bagger; Natalia Bellostas; Søren Krogh Jensen; Jens Christian Sørensen; Hilmer Sørensen; Susanne Sørensen
Journal of Molecular Catalysis B-enzymatic | 2009
Natalia Bellostas; Anne Dorthe Sørensen; Jens Christian Sørensen; Hilmer Sørensen
Archive | 2007
Natalia Bellostas; Charlotte Bjergegaard; Søren Krogh Jensen; Hilmer Sørensen; Jens Christian Sørensen; Susanne Sørensen
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International Crops Research Institute for the Semi-Arid Tropics
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