Nathalia Costa Gonzaga

Resistência insulínica e sua relação com os componentes da síndrome metabólica

BACKGROUND Individuals with insulin resistance are more prone to the development of metabolic syndrome (MS), Type 2 Diabetes Mellitus and Cardiovascular Disease (CVD) OBJECTIVE: To evaluate the association between insulin resistance (IR) and metabolic syndrome components. METHODS Cross-sectional study of 196 individuals between 2 and 18 years, treated at the Brazilian Public Healthcare system. The association of IR with the MS components was evaluated by Chi-square test, adopting the Homeostasis model assessment-insulin resistance (HOMA-IR) value > 2.5, and by analysis of variance (ANOVA) and Tukeys test, by comparing the means of the components in the HOMA-IR quartiles. Statistical analysis was performed using SPSS 17.0 software and significance level was set at 5%. RESULTS IR was observed in 41.3% of the studied population and was associated with age between 10-18 years (p = 0.002 PR = 3.2), to MS in both sexes [Male (p = 0.022 PR = 3.7) and female (p = 0.007 PR = 2.7)] and altered triglycerides (p = 0.005 PR = 2.9) in females. The mean values of the MS components differed significantly between HOMA-IR quartiles (p <0.01), except for HDL-cholesterol. CONCLUSION Insulin resistance can be considered a marker of cardiovascular risk.

Leptin and cardiometabolic risk factors in obese children and adolescents

To verify the relationship between leptin and cardiometabolic risk factors in obese children and adolescents.

C-reactive protein and its relation to high blood pressure in overweight or obese children and adolescents.

OBJECTIVE To investigate the association between C-reactive protein (CRP) and high blood pressure (BP) in overweight or obese children and adolescents. METHODS Cross-sectional study with 184 overweight or obese children and adolescents aged from two to 18 years old, from April, 2009 to April, 2010. The classification of nutritional status used the body mass index (BMI). Based on the Centers for Disease Control and Prevention curve, individuals were classified as: overweight (BMI between the 85th-95th percentiles), obesity (BMI between 95th-97th percentiles) and severe obesity (BMI >97th percentile). Abnormal values were considered for systolic BP (SBP) and/or diastolic (DBP) if ≥90th percentile of the BP curve recommended for children and adolescents in the V Brazilian Guidelines on Hypertension, for waist circumference (WC) if ≥90th percentile of the curve established by the National Cholesterol Education Program, and for high sensitive CRP (hs-CRP) if >3mg/dL. To evaluate the association of inadequate values of CRP and the studied groups, chi-square test and analysis of variance were applied, using the Statistical Package for the Social Sciences version 17.0 and adopting a significance level of 5%. RESULTS Among the evaluated sample, 66.3% were female, 63.5%, non-white, 64.1% had severe obesity, 78.3% had altered WC and 70.6% presented high BP. There was a significant association of CRP high levels with altered WC and BMI ≥97th percentile. In adolescents, high CRP was related to high SBP. CRP mean values were higher in individuals with elevated SBP. CONCLUSIONS Inadequate values of hs-CRP were associated with severe obesity and high SBP in the studied population. These markers can be used to identify children and adolescents at higher risk for developing atherosclerosis.ABSTRACT Objective : To investigate the association between C-reactive protein (CRP) and high blood pressure (BP) in overweight or obese children and adolescents. Methods: Cross-sectional study with 184 overweight or obese children and adolescents aged from two to 18 years old, from April, 2009 to April, 2010. The classification of nutritional status used the body mass index (BMI). Based on the Centers for Disease Control and Prevention curve, individuals were classified as: overweight (BMI between the 85 th –95 th percentiles), obesity (BMI between 95 th –97 th percentiles) and severe obesity (BMI >97 th percentile). Abnormal values were considered for systolic BP (SBP) and/ Endereco para correspondencia:Anajas da Silva CardosoRua Treze de Maio, 221 CEP 58400-290 – Campina Grande/PB E-mail: anajascardoso@gmail.comFonte financiadora: Fundacao de Apoio a Pesquisa do Estado da Paraiba (Fapesq) e Universidade Estadual da Paraiba (UEPB), sob concessao de ajuda de custo mediante aprovacao da pesquisa em editalConflito de interesse: nada a declararRecebido em: 5/10/2010Aprovado em: 14/2/2013

Proteína C-reativa e sua relação com pressão arterial elevada em crianças e adolescentes com sobrepeso ou obesidade

OBJECTIVE To investigate the association between C-reactive protein (CRP) and high blood pressure (BP) in overweight or obese children and adolescents. METHODS Cross-sectional study with 184 overweight or obese children and adolescents aged from two to 18 years old, from April, 2009 to April, 2010. The classification of nutritional status used the body mass index (BMI). Based on the Centers for Disease Control and Prevention curve, individuals were classified as: overweight (BMI between the 85th-95th percentiles), obesity (BMI between 95th-97th percentiles) and severe obesity (BMI >97th percentile). Abnormal values were considered for systolic BP (SBP) and/or diastolic (DBP) if ≥90th percentile of the BP curve recommended for children and adolescents in the V Brazilian Guidelines on Hypertension, for waist circumference (WC) if ≥90th percentile of the curve established by the National Cholesterol Education Program, and for high sensitive CRP (hs-CRP) if >3mg/dL. To evaluate the association of inadequate values of CRP and the studied groups, chi-square test and analysis of variance were applied, using the Statistical Package for the Social Sciences version 17.0 and adopting a significance level of 5%. RESULTS Among the evaluated sample, 66.3% were female, 63.5%, non-white, 64.1% had severe obesity, 78.3% had altered WC and 70.6% presented high BP. There was a significant association of CRP high levels with altered WC and BMI ≥97th percentile. In adolescents, high CRP was related to high SBP. CRP mean values were higher in individuals with elevated SBP. CONCLUSIONS Inadequate values of hs-CRP were associated with severe obesity and high SBP in the studied population. These markers can be used to identify children and adolescents at higher risk for developing atherosclerosis.ABSTRACT Objective : To investigate the association between C-reactive protein (CRP) and high blood pressure (BP) in overweight or obese children and adolescents. Methods: Cross-sectional study with 184 overweight or obese children and adolescents aged from two to 18 years old, from April, 2009 to April, 2010. The classification of nutritional status used the body mass index (BMI). Based on the Centers for Disease Control and Prevention curve, individuals were classified as: overweight (BMI between the 85 th –95 th percentiles), obesity (BMI between 95 th –97 th percentiles) and severe obesity (BMI >97 th percentile). Abnormal values were considered for systolic BP (SBP) and/ Endereco para correspondencia:Anajas da Silva CardosoRua Treze de Maio, 221 CEP 58400-290 – Campina Grande/PB E-mail: anajascardoso@gmail.comFonte financiadora: Fundacao de Apoio a Pesquisa do Estado da Paraiba (Fapesq) e Universidade Estadual da Paraiba (UEPB), sob concessao de ajuda de custo mediante aprovacao da pesquisa em editalConflito de interesse: nada a declararRecebido em: 5/10/2010Aprovado em: 14/2/2013

Proteína C-reactiva y su relación con la presión arterial elevada en niños y adolescentes con sobrepeso u obesidad

OBJECTIVE To investigate the association between C-reactive protein (CRP) and high blood pressure (BP) in overweight or obese children and adolescents. METHODS Cross-sectional study with 184 overweight or obese children and adolescents aged from two to 18 years old, from April, 2009 to April, 2010. The classification of nutritional status used the body mass index (BMI). Based on the Centers for Disease Control and Prevention curve, individuals were classified as: overweight (BMI between the 85th-95th percentiles), obesity (BMI between 95th-97th percentiles) and severe obesity (BMI >97th percentile). Abnormal values were considered for systolic BP (SBP) and/or diastolic (DBP) if ≥90th percentile of the BP curve recommended for children and adolescents in the V Brazilian Guidelines on Hypertension, for waist circumference (WC) if ≥90th percentile of the curve established by the National Cholesterol Education Program, and for high sensitive CRP (hs-CRP) if >3mg/dL. To evaluate the association of inadequate values of CRP and the studied groups, chi-square test and analysis of variance were applied, using the Statistical Package for the Social Sciences version 17.0 and adopting a significance level of 5%. RESULTS Among the evaluated sample, 66.3% were female, 63.5%, non-white, 64.1% had severe obesity, 78.3% had altered WC and 70.6% presented high BP. There was a significant association of CRP high levels with altered WC and BMI ≥97th percentile. In adolescents, high CRP was related to high SBP. CRP mean values were higher in individuals with elevated SBP. CONCLUSIONS Inadequate values of hs-CRP were associated with severe obesity and high SBP in the studied population. These markers can be used to identify children and adolescents at higher risk for developing atherosclerosis.ABSTRACT Objective : To investigate the association between C-reactive protein (CRP) and high blood pressure (BP) in overweight or obese children and adolescents. Methods: Cross-sectional study with 184 overweight or obese children and adolescents aged from two to 18 years old, from April, 2009 to April, 2010. The classification of nutritional status used the body mass index (BMI). Based on the Centers for Disease Control and Prevention curve, individuals were classified as: overweight (BMI between the 85 th –95 th percentiles), obesity (BMI between 95 th –97 th percentiles) and severe obesity (BMI >97 th percentile). Abnormal values were considered for systolic BP (SBP) and/ Endereco para correspondencia:Anajas da Silva CardosoRua Treze de Maio, 221 CEP 58400-290 – Campina Grande/PB E-mail: anajascardoso@gmail.comFonte financiadora: Fundacao de Apoio a Pesquisa do Estado da Paraiba (Fapesq) e Universidade Estadual da Paraiba (UEPB), sob concessao de ajuda de custo mediante aprovacao da pesquisa em editalConflito de interesse: nada a declararRecebido em: 5/10/2010Aprovado em: 14/2/2013