Nein-Chen Chang

An efficient synthesis of N-benzyl-3-sulfonyl glutarimides. Formal synthesis of the aromatase inhibitor AG-1

Abstract A formal [3+3] cycloaddition strategy to substituted glutarimides was studied. N -Benzyl α-sulfonylacetamides and various α,β-unsaturated esters were used as starting materials.

An efficient synthesis of γ-substituted α,β-unsaturated-δ-lactams. Formal synthesis of (±)-protoemetinol

Abstract γ-Substituted α,β-unsaturated δ-lactams 1 was synthesized from α-sulfinyl acetamides 3 in three steps. Formal synthesis of (±)-protoemetinol was also reported.