Nelson Alvis

Mathematical Models of Cervical Cancer Prevention in Latin America and the Caribbean

Using population and epidemiologic data for 33 countries in Latin America and the Caribbean (LAC), a model-based approach estimated averted cervical cancer cases and deaths, disability-adjusted life years (DALYs) and incremental cost-effectiveness ratios (I

Leptospirosis ocupacional en una región del Caribe colombiano

/DALY averted) for human papillomavirus (HPV) vaccination of young adolescent girls. Absolute reduction in lifetime cancer risk varied between countries, depending on incidence, proportion attributable to HPV-16 and 18, and population age-structure; for example, with 70% coverage, cancer reduction ranged from 40% in Mexico to more than 50% in Argentina. Screening of women over age 30 three times per lifetime, after vaccinating them as pre-adolescents, is expected to provide a relative increase of 25% to 30% in mortality reduction. Countries with the highest risk of cancer (age-standardized rate > 33.6) accounted for only 34% of deaths averted with vaccination, highlighting why a regional universal vaccination approach will be most effective in reducing the overall global burden. At I

Potential epidemiological and economical impact of two rotavirus vaccines in Colombia.

25 per vaccinated girl (

Mortalidad por Acinetobacter baumannii en unidades de cuidados intensivos en Colombia

5 per dose), for all 33 countries, the cost per DALY averted is less than I

Infecciones de Transmisión Sexual en un Grupo de Alto Riesgo de la Ciudad de Montería, Colombia

400; at I

Alta Prevalencia de Anticuerpos contra Bartonella y Babesia microti en Poblaciones Rurales y Urbanas en dos Provincias de Córdoba, Colombia

10 (

Meningitis Agudas en Córdoba,Colombia 2002 - 2004

2 per dose) the vaccine is cost saving in 26 out of 33 countries. For all countries, ratios become less attractive (i.e., increase) as the cost of the vaccine increases. For example, at current vaccine prices (

Impacto económico de la introducción de la vacuna inactivada inyectable contra la poliomielitis en Colombia

120 per dose), the cost per DALY averted is I

Hepatitis B oculta en pacientes VIH positivos de una institución de salud en Barranquilla Colombia.

7,300 in Mexico, I

Los QALYs y DALYs como indicadores sintéticos de salud

3,700 in Nicaragua, and I