Nelson H. Stone

Effect of Reserpine on Peptic Ulceration and Gastric Blood Flow in Dogs.

Summary Reserpine, in large doses, abets histamine induced ulceration in dogs. It also appears to be as ulcerogenic as histamine. Decreased blood flow occurs in the stomach when 2.5 mg of reserpine is given intravenously to dogs. This may be an additional mechanism for the increased incidence of ulceration.

The role of the small intestine in gastric hypersecretion following portacaval shunt

Summary Resection of either the jejunum or ileum does not alter gastric hypersecretion following portacaval shunt. Ileectomy increases the susceptibility of a dog with portacaval shunt to meat intoxication.

Influence of Local Hypothermia on Absorption from Isolated Intestinal Segments.

Conclusions Our results indicate that hypothermia reduced net transport of substances from gut lumen to blood stream. In strychnine absorption, systemic hypothermia (25-30°C), at clinically feasible levels is not as effective in delaying transport as local hypothermia (10°C). Neither protects the animals from fatal outcome when large doses are used. Hypothermia reduced absorption of RISA approximately ninefold, (p = .005) while it reduced absorption of I131 only 5-fold (p = <.01). Venous return in hypothermic intestinal loops is reduced 72 and 66% in closed jejunal and ileal segments.

Role of the Sex Hormones in Peptic Ulcer.

Summary Histamine induced ulceration in the dog is enhanced by daily administration of 5 mg of diethyl stilbestrol or 100 mg of testosterone cyclopentylpropionate. Secretion from Heidenhain pouches in dogs is not significantly changed by daily administration of these drugs.

Role of the pulsatile thrust of the aorta in genesis of gastric ulcer.

Conclusions and summary 1. Retroaortic placement of the fundus of the dogs stomach is followed by development of gastric ulcer at site of impingement of the aortic thrust upon the gastric wall. Perforation with formation of a gastroaortic fistula was a frequent sequel. 2. It is not unlikely in man that the mid lesser curvature gastric ulcer owes its origin in part to the thrust of aortic pulsations.