Neva M. Abelson

Studies on the Pathogenesis of Rheumatoid Joint Inflammation: II. Intracytoplasmic Particulate Complexes in Rheumatoid Synovial Fluids

Excerpt The etiology and pathogenesis of rheumatoid arthritis are not known. Many studies have described the clinical and pathological characteristics of the disease process. Numerous additional st...

The Reactions between Blood Group Antibodies and Antisera to Purified Immunoglobulins

Rabbit antibody to chromatographically separated 7S gamma globulin proved to be a potent anti‐gamma globulin reagent, capable of potentiating the serologic activity of blood group antibodies of the 7S gamma globulin class without dependence on complement.

Autoimmune hemolytic anemia in an infant. Report of a case treated unsuccessfully with thymectomy.

A case of autoimmune hemolytic anemia in a 6-week-old infant is reported. Treatment with steroids, 6-mercaptopurine, heparin, anti-snake venom, and exchange transfusion were ineffectual. Thymectomy and splenectomy failed to induce a remission.

Rheumatoid Arthritis, Rheumatoid Factor, and Gamma G Globulin Fragments.

Excerpt Rheumatoid factor (RF) is an antibody toalteredimmunoglobulin G (IgG), but its role in pathogenesis of rheumatoid arthritis (RA) has not been established, nor has the nature or origin of an...

The Blood Group Antibody “Good,” 1966 II. Physicochemical Studies

The physicochemical characteristics of the Good antibody were studied further. The antibody consisted of two molecular types, one associated with IgG globulin, and the other probably associated with IgM globulin. The two types differed in complement binding capacity and in sulfhydryl sensitivity. Both were “complete” agglutinins reacting best at 4 C. The IgG antibody was not potentiated by antiglobulin serum. The physicochemical and serologic characteristics of the antibody placentally transferred to the Good‐negative infant born in 1966 resembled those of the IgG antibody.