Nicola Mammarella

Noradrenergic modulation of emotional memory in aging

Interest in the role of the noradrenergic system in the modulation of emotional memories has recently increased. This study briefly reviews this timely line of research with a specific focus on aging. After having identified surprisingly few studies that investigated emotional memory in older adults from a neurobiological perspective, we found a significant interaction between noradrenergic activity and emotional memory enhancement in older adults. This pattern of data are explained both in terms of a top-down modulation of behavioral processes (e.g., changes in priority and individual goals) and in terms of greater activity of noradrenergic system during aging. Altogether, both behavioral and genetic variations studies (e.g., Alpha 2 B Adrenoceptor genotype) have shown that healthy older adults are able to circumvent or minimize the experience of negative emotions and stabilize or even enhance positive emotional experiences. Future studies are highly warranted to better clarify the relationship between noradrenaline and emotional memories in the aging brain.

Comparing different types of source memory attributes in dementia of Alzheimer's type.

BACKGROUND Source monitoring (SM) refers to our ability to discriminate between memories from different sources. METHODS Twenty healthy high-cognitive functioning older adults, 20 healthy low-cognitive functioning older adults, and 20 older adults with dementia of Alzheimers type (DAT) were asked to perform a series of SM tasks that varied in terms of the to-be-remembered source attribute (perceptual, spatial, temporal, semantic, social, and affective details). RESULTS Results indicated that older DAT adults had greater difficulty in SM compared to the healthy control groups, especially with spatial and semantic details. CONCLUSIONS Data are discussed in terms of the SM framework and suggest that poor memory for some types of source information may be considered as an important indicator of clinical memory function when assessing for the presence and severity of dementia.

Facial Emotion Recognition in Bipolar Disorder and Healthy Aging.

Abstract Emotional face recognition is impaired in bipolar disorder, but it is not clear whether this is specific for the illness. Here, we investigated how aging and bipolar disorder influence dynamic emotional face recognition. Twenty older adults, 16 bipolar patients, and 20 control subjects performed a dynamic affective facial recognition task and a subsequent rating task. Participants pressed a key as soon as they were able to discriminate whether the neutral face was assuming a happy or angry facial expression and then rated the intensity of each facial expression. Results showed that older adults recognized happy expressions faster, whereas bipolar patients recognized angry expressions faster. Furthermore, both groups rated emotional faces more intensely than did the control subjects. This study is one of the first to compare how aging and clinical conditions influence emotional facial recognition and underlines the need to consider the role of specific and common factors in emotional face recognition.

Is there an affective working memory deficit in patients with chronic schizophrenia

Research interest in affective working memory has rapidly grown in the last decade. In this study we investigated working memory functions for affective and neutral words in a group of 22 patients with chronic schizophrenia and 22 healthy controls. In particular, participants were administered the operation working memory span task in which affective and neutral words had to be remembered. Results showed that patients made significantly more intrusion errors, recalling off-goal information, and showed poorer long-term memory performance than controls. In addition, affective trials showed the largest number of intrusion errors. These results suggest that a general attentional control deficit, especially over affective information, may underly failures to remember in chronic schizophrenia patients.

Fighting apathy in Alzheimer's dementia: A brief emotional-based intervention

Lack of motivation, or apathy, is a clinically significant feature among dementia patients. The current study aimed to assess the effectiveness of a brief emotional shaping intervention developed to reduce apathy and increase willingness-to-do in Alzheimers Dementia patients. To this end, 26 Alzheimer patients diagnosed with apathy according to the Apathy Evaluation Scale (AES, Marin et al.,1991) and 26 healthy older controls performed an emotional shaping task intended to unconsciously foster willingness-to-do. Participants were randomly assigned to either a positive or a neutral conditioning situation. Results showed how the positively conditioned group was associated with improved willingness-to-do in both patients and controls compared to the neutrally conditioned group. Our findings suggest that unconscious emotional processing can be used to treat apathy symptoms and increase willingness-to-do in Alzheimers Dementia.

The modulating role of ADRA2B in emotional working memory: Attending the negative but remembering the positive.

Previous studies found that the ADRA2B gene modulates early perception and attention. Here, we aimed to examine whether ADRA2B polymorphisms also influence emotional working memory and the willingness to implement behaviors (switching affective intonation) in order to avoid negative information, both considered indexes of cognitive-affective flexibility. We examined genotype data collected from 212 healthy females, 91 ADRA2B carriers and 121 non-carriers, and found that carriers showed a positivity bias in working memory. That is, carriers remembered a higher number of positive words compared to negative and neutral words. In addition, although carriers were more unwilling to switch intonation in order to avoid negative information, they showed better recognition memory for words read with a positive intonation. These findings suggest that deletion variants of ADRA2B may show greater levels of cognitive-affective flexibility compared to non-carriers.

Emotional Meta-Memories: A Review

Emotional meta-memory can be defined as the knowledge people have about the strategies and monitoring processes that they can use to remember their emotionally charged memories. Although meta-memory per se has been studied in many cognitive laboratories for many years, fewer studies have explicitly focused on meta-memory for emotionally charged or valenced information. In this brief review, we analyzed a series of behavioral and neuroimaging studies that used different meta-memory tasks with valenced information in order to foster new research in this direction, especially in terms of commonalities/peculiarities of the emotion and meta-memory interaction. In addition, results further support meta-cognitive models that take emotional factors into account when defining meta-memory per se.

Is there a “special relationship” between unconscious emotions and visual imagery? Evidence from a mental rotation test

There is an increasing interest in the relationship between imagery and emotion (e.g., Holmes & Mathews, 2005). The present research examined whether unconscious emotions affect visual imagery. In particular, participants were invited to perform a mental rotation test following subliminal presentation of happy, sad and neutral expressions. This study revealed an increase in mental rotation abilities after unconscious visual processing of emotional expressions. Altogether, these findings support the hypothesis of a bidirectional relationship between imagery and emotions.

Is working memory affective in dementia of alzheimer's type?

Abstract Background: The aim of the present study was to examine whether patients with Dementia of Alzheimers Type (DAT) show a working memory emotional enhancement effect. Methods: We used an

Are all forms of feature binding disturbed in schizophrenia? Evidence from a central vs. peripheral distinction in working memory

In this study we investigated central and peripheral feature binding in a group of 24 high pre-morbid IQ patients with schizophrenia and 24 healthy controls. In particular, participants were asked to remember specific single (e.g., word, colour) or multiple features (e.g., coloured words) of experimental items with central (coloured word) vs. peripheral (a coloured frame) attributes in a working memory binding task. Performance of the patients was significantly inferior to that of controls, especially when required to remember the peripheral combination of multiple features. Results suggest that patients with schizophrenia may have difficulties in unitizing peripheral features in working memory.