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Featured researches published by Nicola Zingaretti.


Journal of Craniofacial Surgery | 2016

Cranioplasty: Review of Materials.

Bruno Zanotti; Nicola Zingaretti; Angela Verlicchi; Massimo Robiony; Alex Alfieri; Pier Camillo Parodi

AbstractCranioplasty remains a difficult procedure for all craniofacial surgeons, particularly when concerning the reconstruction of large lacunae in the skull. Considering the significant clinical and economic impact of the procedure, the search for materials and strategies to provide more comfortable and reliable surgical procedures is one of the most important challenges faced by modern craniofacial medicine.The purpose of this study was to compare the available data regarding the safety and clinical efficacy of materials and techniques currently used for the reconstruction of the skull. Accordingly, the scientific databases were searched for the following keywords autologous bone, biomaterials, cranial reconstruction, cranioplasty, hydroxyapatite, polyetheretherketone, polymethylmethacrylate, and titanium. This literature review emphasizes the benefits and weaknesses of each considered material commonly used for cranioplasty, especially in terms of infectious complications, fractures, and morphological outcomes.As regards the latter, this appears to be very similar among the different materials when custom three-dimensional modeling is used for implant development, suggesting that this criterion is strongly influenced by implant design. However, the overall infection rate can vary from 0% to 30%, apparently dependent on the type of material used, likely in virtue of the wide variation in their chemico-physical composition. Among the different materials used for cranioplasty implants, synthetics such as polyetheretherketone, polymethylmethacrylate, and titanium show a higher primary tear resistance, whereas hydroxyapatite and autologous bone display good biomimetic properties, although the latter has been ascribed a variable reabsorption rate of between 3% and 50%.In short, all cranioplasty procedures and materials have their advantages and disadvantages, and none of the currently available materials meet the criteria required for an ideal implant. Hence, the choice of cranioplasty materials is still essentially reliant on the surgeons preference.


Plastic and Aesthetic Research | 2015

Surgical pitfalls with custom-made porous hydroxyapatite cranial implants

Bruno Zanotti; Angela Verlicchi; Roberto Stefini; Attilio Carlo Salgarelli; Nicola Zingaretti; Pier Camillo Parodi; Casadei Matteo; Massimo Robiony

Aim: Cranioplasty implants are used primarily in cases of surgical cranial decompression following pathological elevations of intracranial pressure. Available bone substitutes include porous hydroxyapatite (HA) and polymethylmethacrylate. Whichever material is used, however, prosthetic cranial implants are susceptible to intra- and postsurgical complications and even failure. The aim of this study was to investigate such occurrences in HA cranioplasty implants, seeking not only to determine the likely causes (whether correlated or not with the device itself) but also, where possible, to suggest countermeasures. Methods: We analyzed information regarding failures or complications reported in postmarketing surveillance and clinical studies of patients treated worldwide with custom-made HA cranial implants (Custom Bone Service Fin-Ceramica Faenza, Italy) in the period 1997-2013. Results: The two most common complications were implant fractures (84 cases, 2.9% of the total fitted) and infections (51 cases, 1.77%). Conclusion: Although cranioplasties are superficial and not difficult types of surgery, and use of custom-made implants are often considered the easy option from a surgical perspective, these procedures are nonetheless plagued by potential pitfalls. If performed well they yield more than satisfactory results from the points of view of both the patient and surgeon, but lack of appropriate care can open the door to numerous potential sources of failure, which can compromise-even irreparably-the ability to heal.


Indian Journal of Plastic Surgery | 2017

A new method of salvaging nipple projection after secondary nipple reconstruction using locoregional flap

Fabrizio De Biasio; Nicola Zingaretti; Sebastiano Mura; Alessandra Fin; Michele Riccio; Pier Camillo Parodi

Sir, The most important features of a natural reconstructed nipple are symmetry and a durable valid vertical projection. A frequent drawback of the methods currently used for nipple reconstruction is the loss of nipple projection in the longer post‐operative term. Although numerous nipple‐areolar complex reconstruction techniques have been described,[1‐3] common among these techniques is a failure to maintain a nipple projection over time (estimated at 17%–75%), and difficulties related to maintenance of nipple projection have been well documented.[4]


Indian Journal of Plastic Surgery | 2014

Enhancing dermal and bone regeneration in calvarial defect surgery

Bruno Zanotti; Nicola Zingaretti; Daria Almesberger; Angela Verlicchi; Roberto Stefini; Mauro Ragonese; Gianni Franco Guarneri; Pier Camillo Parodi

Introduction: To optimize the functional and esthetic result of cranioplasty, it is necessary to choose appropriate materials and take steps to preserve and support tissue vitality. As far as materials are concerned, custom-made porous hydroxyapatite implants are biomimetic, and therefore, provide good biological interaction and biointegration. However, before it is fully integrated, this material has relatively low mechanical resistance. Therefore, to reduce the risk of postoperative implant fracture, it would be desirable to accelerate regeneration of the tissues around and within the graft. Objectives: The objective was to determine whether integrating growth-factor-rich platelet gel or supportive dermal matrix into hydroxyapatite implant cranioplasty can accelerate bone remodeling and promote soft tissue regeneration, respectively. Materials and Methods: The investigation was performed on cranioplasty patients fitted with hydroxyapatite cranial implants between 2004 and 2010. In 7 patients, platelet gel was applied to the bone/prosthesis interface during surgery, and in a further 5 patients, characterized by thin, hypotrophic skin coverage of the cranial lacuna, a sheet of dermal matrix was applied between the prosthesis and the overlying soft tissue. In several of the former groups, platelet gel mixed with hydroxyapatite granules was used to fill small gaps between the skull and the implant. To confirm osteointegration, cranial computed tomography (CT) scans were taken at 3-6 month intervals for 1-year, and magnetic resonance imaging (MRI) was used to confirm dermal integrity. Results: Clinical examination performed a few weeks after surgery revealed good dermal regeneration, with thicker, healthier skin, apparently with a better blood supply, which was confirmed by MRI at 3-6 months. Furthermore, at 3-6 months, CT showed good biomimetism of the porous hydroxyapatite scaffold. Locations at which platelet gel and hydroxyapatite granules were used to fill gaps between the implant and skull appeared to show more rapid integration of the implant than untreated areas. Results were stable at 1-year and remain so to date in cases where follow-up is still ongoing. Conclusions: Bone remodeling time could be reduced by platelet gel application during cranioplasty with porous hydroxyapatite implants. Likewise, layering dermal matrix over such implants appears to promote dermal tissue regeneration and the oshtemo mimetic process. Both of these strategies may, therefore, reduce the likelihood of postsurgical fracture by promoting mechanical resistance.


Journal of Materials Science: Materials in Medicine | 2018

The amnion muscle combined graft (AMCG) conduits in nerves repair: an anatomical and experimental study on a rat model

Andrea Marchesini; Stefania Raimondo; Nicola Zingaretti; Valentina Riccio; Bruno Battiston; Mauro Provinciali; Stefano Geuna; Michele Riccio

AbstractThe amnion muscle combined graft (AMCG) conduits showed good clinical results in peripheral nerves gap repair. It combines the human amniotic membrane with autologous skeletal muscle fibres. These results seem attributable to the biological characteristics of human amniotic membrane: Pluripotency, anti-inflammatory and low immunogenicity.We here evaluate the final outcome of nerve regeneration morphologically and functionally, across the AMCG compared to nerve autograft. Fourteen Wistar rats were divided into two groups: In Group A, including 6 rats, the left forelimb was treated performing a 1.5 cm length gap on median nerve that was then reconstructed with a reverse autograft. In Group B, including 8 rats, the gap was reconstructed with AMCG. Functional results were evaluated at 30, 60 and 90 days performing grasping tests. Morphological and stereological analyses were performed at T90 using high-resolution light microscopy and design-based stereology. The AMCG conduits revealed nerve fibres regeneration and functional recovery. Functional recovery was observed in both groups with AMCG conduits group showing lower values and a regeneration of median nerves with more myelinated fibres with the same axon size, but thinner myelin than the autograft group. Though the autograft remains the gold standard to restore wide nerve gaps, the AMCG conduit has proved to be effective in enabling nerve regeneration through a critical rat’s nerve gap of 15 mm. These findings empirically support the great clinical results obtained using AMCG conduit to restore traumatic nerve’s gap from 3 to 6 cm of mixed forearm nerves.


The Pan African medical journal | 2017

A case of gestational gigantomastia in a 37-years-old woman associated with elevated ANA: a casual linkage?

Nicola Zingaretti; Fabrizio De Biasio; Michele Riccio; Nastassia Nardini; Laura Mariuzzi; Pier Camillo Parodi

Hypertrophy of the breast (macromastia and gigantomastia) is a rare medical condition of the breast connective tissues. The etiology of this condition is still not clear; rarely, gigantomastia has been reported to develop in the setting of an autoimmune illness. We reported a case of a 37-years-old woman with undifferentiated connective tissue disease of 2-years duration presented with enlargement of breasts. The breast enlargment started at 5 months of gestation. She successfully underwent reduction mammoplasty with free nipple graft. In the succeeding months the level of antinuclear ANA remained stable. It is uncertain whether a positive antinuclear antibodies in gigantomastia is a casuative agent or an effect.


Journal of Craniofacial Surgery | 2017

An Efficient Method for Hair Containment During Head and Neck Surgery

Nicola Zingaretti; Fabrizio De Biasio; Michele Riccio; Andrea Marchesi; Pier Camillo Parodi

The authors present a simple technique for operations around hair-bearing areas such as during a rhytidectomy. Hair surrounding the surgical field is twisted into bundles and clipped with duckbill clips. The authors repeat the procedure for each strand of hair. Between 5 and 7 duckbill clips may be required per surgery.The clippers are faster, easily applicable, and well performing. They can be used with different hair lengths, and they do not require any additional trimming or shaving; clips also keep the hair firmly in place, and they do not loosen up in the process.This technical note explains a very simple, economical, and less time-consuming method to control hair located around the surgical site. It may be applied to all procedures within the field of the hair-bearing scalp, including craniofacial and maxillofacial surgery.


Acta Neurochirurgica | 2015

Spontaneous fractures in custom-made porous hydroxyapatite cranioplasty implants: is fragility the only culprit?

Bruno Zanotti; Angela Verlicchi; Stefano Indiani; Stefano Alves Scarparo; Nicola Zingaretti; Pier Camillo Parodi


Aesthetic Plastic Surgery | 2017

Reduction Mammaplasty for Breast Symmetrisation in Implant-Based Reconstructions

Fabrizio De Biasio; Nicola Zingaretti; Francesca De Lorenzi; Michele Riccio; Luca Vaienti; Pier Camillo Parodi


Aesthetic Plastic Surgery | 2016

The Use of “Precapsular Space” in Secondary Breast Reconstruction

Nicola Zingaretti; Francesca De Lorenzi; Francesco Dell’Antonia; Fabrizio De Biasio; Michele Riccio; Pier Camillo Parodi

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Francesca De Lorenzi

European Institute of Oncology

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