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Dive into the research topics where Nicolas Molinari is active.

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Featured researches published by Nicolas Molinari.


Journal of Asthma | 2014

Home-based respiratory rehabilitation in adult patients with moderate or severe persistent asthma

Delphine Renolleau-Courtois; Aurore Lamouroux-Delay; S. Delpierre; Monique Badier; Francoise Lagier-Tessonnier; Alain Palot; Marion Gouitaa; Céline Tummino; D. Charpin; Nicolas Molinari; Pascal Chanez

Abstract Objective: We assessed retrospectively the feasibility of a home-based respiratory rehabilitation (RR) program for asthmatics under optimal pharmacological treatment, as this type of care can reduce costs and offer a more patient-friendly approach for subjects with persistent asthma. Methods: Fifty-two patients with persistent asthma were recruited to the RR program (20 males, 32 females, 54 ± 11 (SD) years, forced expiratory volume in one second 71 ± 33% of predicted mean value, BMI 29.9 ± 7.9 kg/m2). This two-month protocol comprised education sessions, respiratory physiotherapy and an exercise training program at home and in groups supervised by an adapted physical activity instructor. Results: Thirty-nine patients completed the whole RR program, i.e. 25% dropout. The dropout rate was significantly higher with respect to younger patients in employment. The number of exacerbations decreased significantly during the year following the program, regardless of whether the patients had dropped out (p < 0.02) or not (p < 0.001). The distance walked during a 6-min walking test increased by 33 m (p < 0.001). Several indices measured during a cycle ergometer test increased significantly after RR: peak oxygen uptake (10%), oxygen uptake at ventilatory threshold (12%) and maximum load (19%), all at a similar maximum heart rate. Concerning quality of life assessment, the Short-Form-36 Item Health Survey revealed a non-significant improvement in the “health change” item after RR (p < 0.07). Conclusions: This study demonstrates the potential of a home-based program in the treatment and rehabilitation of patients with asthma. Both functional and physiologic indices improved during the follow-up period.


Oxidative Medicine and Cellular Longevity | 2015

Heterogeneity of Systemic Oxidative Stress Profiles in COPD: A Potential Role of Gender.

Jonathan Maury; Fares Gouzi; Philippe De Rigal; Nelly Heraud; Joël Pincemail; Nicolas Molinari; Pascal Pomiès; Dalila Laoudj-Chenivesse; J. Mercier; Christian Préfaut; Maurice Hayot

Oxidative stress (OS) plays a key role in the muscle impairment and exercise capacity of COPD patients. However, the literature reveals that systemic OS markers show great heterogeneity, which may hinder the prescription of effective antioxidant supplementation. This study therefore aimed to identify OS markers imbalance of COPD patients, relative to validated normal reference values, and to investigate the possibility of systemic OS profiles. We measured systemic enzymatic/nonenzymatic antioxidant and lipid peroxidation (LP) levels in 54 stable COPD patients referred for a rehabilitation program. The main systemic antioxidant deficits in these patients concerned vitamins and trace elements. Fully 89% of the COPD patients showed a systemic antioxidant imbalance which may have caused the elevated systemic LP levels in 69% of them. Interestingly, two patient profiles (clusters 3 and 4) had a more elevated increase in LP combined with increased copper and/or decreased vitamin C, GSH, and GPx. Further analysis revealed that the systemic LP level was higher in COPD women and associated with exercise capacity. Our present data therefore support future supplementations with antioxidant vitamins and trace elements to improve exercise capacity, but COPD patients will probably show different positive responses.


Archive | 2018

The eo-Delphi protocol

Carey M Suehs; Nicolas Molinari; Isabelle Vachier; Arnaud Bourdin


Archive | 2018

Initial demographic and opinion questionnaire

Carey M Suehs; Isabelle Vachier; Nicolas Molinari; Arnaud Bourdin


Archive | 2017

PROTOACCEPT1: Criteria Associated With Patient Willingness to Participate in Biomedical Research

Laurie Pahus; Laurence Halimi; Carey M Suehs; Isabelle Vachier; Grégory Marin; Nicolas Molinari; Dany Jaffuel; Jean Pierre Mallet; Pascal Chanez; Anne-Sophie Gamez


Archive | 2017

PECTUS-cluster: Clustering Among the Clinical Profiles of Patients With Pectus Excavatum

berthet; Carey M Suehs; Benjamin Nataf; Laurence Solovei; Maurice Hayot; Fares Gouzi; Nicolas Molinari; Arnaud Bourdin


Archive | 2017

INVECCO: Modeling Bronchial Epithelium Modifications Associated With COPD Using iPS

Carey M Suehs; Arnaud Bourdin; Nicolas Molinari; Isabelle Vachier


Archive | 2017

InterfaceVent: Side Effects Related to the Use of an Interface in Home Care Patients Treated for at Least 3 Months by Continuous Positive Pressure or Non-Invasive Ventilation

Dany Jaffuel; Marie Caroline Rotty; Carey M Suehs; Nicolas Molinari


European Respiratory Journal | 2016

LATE-BREAKING ABSTRACT: Antioxidant supplementation in chronic obstructive pulmonary disease (COPD): A relevant way to optimize pulmonary rehabilitation effects

Jonathan Maury; Fares Gouzi; Nelly Heraud; Philippe De Rigal; Nicolas Molinari; Joël Pincemail; Dalila Laoudj-Chenivesse; François Bughin; Magali Poulain; Marine Blaquière; J. Mercier; Christian Préfaut; Pascal Pomiès; Maurice Hayot


Archive | 2015

chronic obstructive pulmonary disease patients reduction are the attributes of different phenotypes in Fiber atrophy, oxidative stress, and oxidative fiber

Christian Préfaut; Dalila Laoudj-Chenivesse; Jean-Paul Cristol; Jacques Mercier; Maurice Hayot; Fares Gouzi; Aldjia Abdellaoui; Nicolas Molinari; Edith Pinot; Bronia Ayoub

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Carey M Suehs

University of Montpellier

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Arnaud Bourdin

University of Montpellier

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Fares Gouzi

University of Montpellier

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Maurice Hayot

University of Montpellier

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Pascal Pomiès

University of Montpellier

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Jacques Mercier

University of Montpellier

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Nelly Heraud

University of Montpellier

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