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Dive into the research topics where Nikhil Misra is active.

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Featured researches published by Nikhil Misra.


European Journal of Trauma and Emergency Surgery | 2018

A systematic review of 3251 emergency department thoracotomies: is it time for a national database?

Edward J. Nevins; Nicholas Thomas Edward Bird; Hassan Z. Malik; Simon Jude Mercer; Khalid Shahzad; Raimundas Lunevicius; John Vincent Taylor; Nikhil Misra

PurposeEmergency department thoracotomy (EDT) is a potentially life-saving procedure, performed on patients suffering traumatic cardiac arrest. Multiple indications have been reported, but overall survival remains unclear for each indication. The objective of this systematic review is to determine overall survival, survival stratified by indication, and survival stratified by geographical location for patients undergoing EDT across the world.MethodsArticles published between 2000 and 2016 were identified which detailed outcomes from EDT. All articles referring to pre-hospital, delayed, or operating room thoracotomy were excluded. Pooled odds ratios (OR) were calculated comparing differing indications.ResultsThirty-seven articles, containing 3251 patients who underwent EDT, were identified. There were 277 (8.5%) survivors. OR demonstrate improved survival for; penetrating vs blunt trauma (OR 2.10; p 0.0028); stab vs gun-shot (OR 5.45; p < 0.0001); signs of life (SOL) on admission vs no SOL (OR 5.36; p < 0.0001); and SOL in the field vs no SOL (OR 19.39; p < 0.0001). Equivalence of survival was demonstrated between cardiothoracic vs non-cardiothoracic injury (OR 1.038; p 1.000). Survival was worse for USA vs non-USA cohorts (OR 1.59; p 0.0012).ConclusionsPenetrating injury remains a robust indication for EDT. Non-cardiothoracic cause of cardiac arrest should not preclude EDT. In the absence of on scene SOL, survival following EDT is extremely unlikely. Survival is significantly higher in the non-USA publications; reasons for this are highly complex. A UK multicentre prospective study which collects standardised data on all EDTs could provide robust evidence for better patient stratification.


European Journal of Trauma and Emergency Surgery | 2018

Should pre-hospital resuscitative thoracotomy be reserved only for penetrating chest trauma?

Edward J. Nevins; Parisa L. Moori; Jonathan Smith-Williams; Nicholas Thomas Edward Bird; John Vincent Taylor; Nikhil Misra


Journal of Gastrointestinal Surgery | 2018

72 h Is the Time Critical Point to Operate in Acute Appendicitis

Mohammed Elniel; Jennie Grainger; Edward J. Nevins; Nikhil Misra; Paul Skaife


International Journal of Surgery | 2014

The emergency general surgical unit: The clinical and economic benefits of the centralisation of emergency general surgery

Caroline Atherton; Raimundas Lunevicius; Richard Ward; Nikhil Misra


International Journal of Surgery | 2013

Pre-operative liver enzyme predicts survival and recurrence after liver resection for hepatocellular carcinoma arising from non-cirrhotic/non-fibrotic liver: A European perspective

C.Y. Tan; V.S. Yip; G. Sarno; S. Staettner; M. Terlizzo; Nikhil Misra; S. Fenwick; H. Malik; Paula Ghaneh; Graeme Poston


Ejso | 2013

The impact of patient fitness on the cost of hepatectomy

Declan Dunne; Nikhil Misra; Glyn Estebanez; Hassan Z. Malik; Graeme Poston; Stephen W. Fenwick


Ejso | 2012

31. Liver resection with vena cava involvement – Experiences of a non-transplant hepatobiliary center

S. Staettner; Vincent Yip; V. Kaliyaperumal; Nikhil Misra; S. Fenwick; Graeme Poston; H. Malik


Ejso | 2012

95. Neoadjuvant chemoembolisation of Colorectal Liver Metastases (CRLM) with Drug Eluting Beads Trans-arterial Chemo-embolization (DEBIRI-TACE); a Multi-institute phase 2 study in resectable metastases

S. Staettner; Robert P. Jones; V.S. Yip; Nikhil Misra; H. Malik; T. Grünberger; S. Fenwick; Graeme Poston


Ejso | 2012

438. Microwave Ablation for the Treatment of Colorectal Liver Metastasis (CLM) – Short- and Midterm Results

S. Staettner; V.S. Yip; K. Buchanan; Robert P. Jones; Nikhil Misra; H. Malik; S. Fenwick; Graeme Poston


Ejso | 2012

439. Surgical Management of Stage 4 Neuroendocrine Disease - a Single Centre Experience

S. Staettner; Robert Jones; Nikhil Misra; V.S. Yip; Declan Dunne; S. Fenwick; H. Malik; G.J. Poston

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H. Malik

St James's University Hospital

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S. Staettner

University of Liverpool

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Declan Dunne

University of Liverpool

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Vincent Yip

University of Liverpool

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