Nikola Krstajić

Focusing optics of a parallel beam CCD optical tomography apparatus for 3D radiation gel dosimetry

Optical tomography of gel dosimeters is a promising and cost-effective avenue for quality control of radiotherapy treatments such as intensity-modulated radiotherapy (IMRT). Systems based on a laser coupled to a photodiode have so far shown the best results within the context of optical scanning of radiosensitive gels, but are very slow ( approximately 9 min per slice) and poorly suited to measurements that require many slices. Here, we describe a fast, three-dimensional (3D) optical computed tomography (optical-CT) apparatus, based on a broad, collimated beam, obtained from a high power LED and detected by a charged coupled detector (CCD). The main advantages of such a system are (i) an acquisition speed approximately two orders of magnitude higher than a laser-based system when 3D data are required, and (ii) a greater simplicity of design. This paper advances our previous work by introducing a new design of focusing optics, which take information from a suitably positioned focal plane and project an image onto the CCD. An analysis of the ray optics is presented, which explains the roles of telecentricity, focusing, acceptance angle and depth-of-field (DOF) in the formation of projections. A discussion of the approximation involved in measuring the line integrals required for filtered backprojection reconstruction is given. Experimental results demonstrate (i) the effect on projections of changing the position of the focal plane of the apparatus, (ii) how to measure the acceptance angle of the optics, and (iii) the ability of the new scanner to image both absorbing and scattering gel phantoms. The quality of reconstructed images is very promising and suggests that the new apparatus may be useful in a clinical setting for fast and accurate 3D dosimetry.

Fast laser scanning optical-CT apparatus for 3D radiation dosimetry

Optical computed tomography (optical-CT) of 3D radiation dosimeters is a promising avenue for delivering an economic and reliable quality control of radiotherapy treatments such as intensity modulated radiotherapy, brachytherapy and stereotactic radiosurgery. The main problems in transferring 3D dosimeters to clinical setting have been in (1) the complexity of manufacture and behaviour of 3D dosimeters and (2) time-consuming readout and analysis of 3D dosimeters. This paper addresses the readout problem by showing that fast (20 min tomography scan), precise (projection absorbance signal-to-noise ratio is greater than 100:1 across the absorbance range 0.2 to 1.5) and accurate (good linearity in the calibration curve) measurements are possible using a novel method of optically scanning a laser beam across the 3D dosimeter.

The history and principles of optical computed tomography for scanning 3-D radiation dosimeters

In this paper we describe the particular considerations relating to ultra-rapid, true-3D scanners based on charge-coupled device (CCD) or complementary metal-oxide semiconductor (CMOS) imaging detectors. Central to our ability to image dose distributions has been the development of novel materials whose optical properties change in response to radiation and a survey of these will be given. Finally, we will speculate briefly on the future of the technique.

Quantum Dot Superluminescent Diodes for Optical Coherence Tomography: Device Engineering

We present a 18 mW fiber-coupled single-mode superluminescent diode with 85 nm bandwidth for application in optical coherence tomography (OCT). First, we describe the effect of quantum dot (QD) growth temperature on optical spectrum and gain, highlighting the need for the optimization of epitaxy for broadband applications. Then, by incorporating this improved material into a multicontact device, we show how bandwidth and power can be controlled. We then go on to show how the spectral shape influences the autocorrelation function, which exhibits a coherence length of <;11 μm, and relative noise is found to be 10 dB lower than that of a thermal source. Finally, we apply the optimum device to OCT of in vivo skin and show the improvement that can be made with higher power, wider bandwidth, and lower noise, respectively.

Quantum Dot Superluminescent Diodes for Optical Coherence Tomography: Skin Imaging

We present a high-power (18 mW continuous wave exiting a single-mode fiber and 35 mW exiting the facet), broadband (85 nm full-width at half-maximum) quantum dot-based superluminescent diode, and apply it to a time-domain optical coherence tomography (OCT) setup. First, we test its performance with increasing optical feedback. Then we demonstrate its imaging properties on tissue-engineered (TE) skin and in vivo skin. OCT allows the tracking of epidermal development in TE skin, while the higher power source allows better sensitivity and depth penetration for imaging of in vivo skin layers.

An investigation of the potential of optical computed tomography for imaging of synchrotron-generated x-rays at high spatial resolution

X-ray microbeam radiation therapy (MRT) is a novel form of treatment, currently in its preclinical stage, which uses microplanar x-ray beams from a synchrotron radiation source. It is important to perform accurate dosimetry on these microbeams, but, to date, there has been no accurate enough method available for making 3D dose measurements with isotropic, high spatial resolution to verify the results of Monte Carlo dose simulations. Here, we investigate the potential of optical computed tomography for satisfying these requirements. The construction of a simple optical CT microscopy (optical projection tomography) system from standard commercially available hardware is described. The measurement of optical densities in projection data is shown to be highly linear (r2=0.999). The depth-of-field (DOF) of the imaging system is calculated based on the previous literature and measured experimentally using a commercial DOF target. It is shown that high quality images can be acquired despite the evident lack of telecentricity and despite DOF of the system being much lower than the sample diameter. Possible reasons for this are discussed. Results are presented for a complex irradiation of a 22 mm diameter cylinder of the radiochromic polymer PRESAGE, demonstrating the exquisite dose-painting abilities available in the MRT hutch of beamline ID-17 at the European Synchrotron Radiation Facility. Dose distributions in this initial experiment are equally well resolved on both an optical CT scan and a corresponding transmission image of radiochromic film, down to a line width of 83 microm (6 lp mm(-1)) with an MTF value of 0.40. A group of 33 microm wide lines was poorly resolved on both the optical CT and film images, and this is attributed to an incorrect exposure time calculation, leading to under-delivery of dose. Image artefacts in the optical CT scan are discussed. PRESAGE irradiated using the microbeam facility is proposed as a suitable material for producing phantom samples for quantitative characterization of optical CT microscopy systems.

Optical CT scanning of PRESAGE™ polyurethane samples with a CCD-based readout system

This article demonstrates the resolution capabilities of the CCD scanner under ideal circumstances and describes the first CCD-based optical CT experiments on a new class of dosimeter, known as PRESAGE™ (Heuris Pharma, Skillman, NJ).

Maximising performance of optical coherence tomography systems using a multi-section chirped quantum dot superluminescent diode

Key device requirements for maximising resolution in an optical coherence tomography system are discussed. The design and operating parameters of a multi-contact quantum dot superluminescent diode incorporating a number of features which inhibit lasing are described. Such devices allow the independent tuning of emission power and spectral shape; hence the penetration depth and resolution in optical coherence tomography are decoupled. The emission spectrum of a device utilising chirped quantum dots is shown to be tuned to produce a broadband single Gaussian emission, centred at the required wavelength of 1050nm, with high output powers than a single contact device.

Common path Michelson interferometer based on multiple reflections within the sample arm: sensor applications and imaging artefacts

We present a simple common path dual beam interferometric sensor platform using a low-coherence source. In our implementation we exploit (in a controlled manner) the multiple reflections within the sample arm to provide the reference arm. This simple setup removes the need for a separate reference arm and allows an alternative architecture for using low-coherence sources in interferometric sensors. We demonstrate the sensor characteristics by using it as a vibrometer and displacement sensor (without directional sensitivity). Vibration frequencies from 50 to 300 Hz were measured with 1% precision while displacements from 6 to 24 µm were measured with 125 nm precision and 625 nm resolution. We discuss improvements, limitations and potential applications. Lastly, we point to the artefactual appearance of this sensor in optical coherence tomography setups.

Swept-Source Laser Based on Quantum-Dot Semiconductor Optical Amplifier—Applications in Optical Coherence Tomography

We present a swept-source laser based on a quantum-dot semiconductor optical amplifier (QD SOA) (designed and manufactured by Innolume Gmbh, Germany) as the gain medium. The properties of the laser are as follows: center wavelength is 1220 nm, sweep range is 94 nm (up to 120 nm in manual mode), the peak laser power is 16 mW, and the sweep speed is 100 Hz. We apply the laser in an optical coherence tomography (OCT) configuration and present images of in vivo skin. QD SOA are well suited to OCT and we show the setup can be improved for power, sweep range, and sweep speed.