Nilam C. Dige

Dicationic 1,3-Bis(1-methyl-1H-imidazol-3-ium) Propane Copper(I) Dibromate : Novel Heterogeneous Catalyst for 1,3-Dipolar Cycloaddition

Abstract We disclose synthesis of a novel dicationic 1,3-bis(1-methyl-1H-imidazol-3-ium) propane copper(I) dibromate [Bis-(MIM)](CuBr2)] and explored its potential as a heterogeneous catalyst in 1,3-dipolar cycloaddition for regioselective synthesis of 1, 4-disubstituted-1,2,3- triazoles in excellent yields in ethanol: water (60:40%) system at 80°C. The noteworthy feature of the protocol includes in situ generation of aryl azides by azotisation of aryl as well as alkyl halides with sodium azide thereby enduring facile 1,3-dipolar cycloaddition with terminal alkynes.Graphical Abstract

Green Aspect for Multicomponent Synthesis of Spiro[4H-indeno[1,2-b]pyridine-4,3′-[3H]indoles]

Abstract An efficient, four-component reaction of isatin, 1,3-indanedione, ethyl acetoacetate, and ammonium acetate in ethanol/water (9:1) system furnished spiro[4H-indeno[1,2-b]pyridine-4,3′-[3H]indoles] at room temperature. Merits of the method are mild reaction conditions, simple workup procedure, and ambient temperature. The synthesized compounds exhibit excellent fluorescence properties. GRAPHICAL ABSTRACT

Serendipitous formation of novel class of dichromeno pyrano pyrimidinone derivatives possessing anti-tubercular activity against M. tuberculosis H 37 Rv

One pot three-component reaction of salicylaldehyde, barbituric acid, and 4-OH coumarin catalyzed by ionic liquid, 1-(ethylaceto acetate)-1-(2-hydroxyethyl) piperidinium tetrachloroaluminate [EAHEPiPY]+ [AlCl4]− in water resulted into unexpected formation of a novel class of dichromeno pyrano pyrimidinone derivatives. Synthesized compounds exhibited excellent in vitro anti-tubercular activity against M. tuberculosis H37Rv.Graphical abstract

Synthesis, Photophysical Properties and Application of New Porphyrin Derivatives for Use in Photodynamic Therapy and Cell Imaging

New derivatives of tetrakis(4-carboxyphenyl) porphyrin were designed, synthesized and characterized by IR, proton NMR and mass spectroscopy. The ground and excited state nature of new derivatives were examined using UV-Vis. absorption and fluorescence spectroscopy, fluorescence quantum yield and fluorescence lifetime studies. The singlet oxygen quantum yield of each synthesized derivative of porphyrin was estimated for their further efficacy as potential photosensitizer in biological studies. The significant photophysical data of all synthesized derivatives was supplementary accessed to examine the cell imaging and cytotoxicity against two cancer cell lines viz. MBA-MD-231 and A375. The fluorescence lifetime, fluorescence quantum yield and efficiency of singlet oxygen generation suggests alkyl amine and alkyl hydrazide linked new porphyrin photosensitizers can be useful for PDT agent in cancer treatment.