Dattaprasad M. Pore

One Pot Synthesis of Monoalkylated and Mixed, Dialkylated Meldrum's Acid Derivatives

Abstract A simple one pot method, involving sequential Knoevenagel condensation of Meldrums acid with aromatic aldehydes, conjugate reduction of ylidene Meldrums acid using sodium borohydride followed by alkylation, to prepare mixed dialkylated derivatives of Meldrums acid is described.

Anhydrous Magnesium Sulfate Mediated Solvent-Free Synthesis of Dihydropyrimidin-2(1H)-ones at Ambient Temperature

An anhydrous magnesium sulfate mediated solvent-free protocol is described for the synthesis of dihydropyrimidinones (Biginelli compounds) at ambient temperature.

[C16MPy]AlCl3Br: an efficient novel ionic liquid for synthesis of novel 1,2,4-triazolidine-3-thiones in water

An efficient novel ionic liquid, [C16MPy]AlCl3Br has been synthesized and explored as a catalyst for an eco-friendly synthesis of novel 1,2,4-triazolidine-3-thiones in water at ambient temperature. A variety of aldehydes undergo smooth reaction with thiosemicarbazide and substituted thiosemicarbazides. In the case of substituted thiosemicarbazides the corresponding 1,2,4-triazolidine-3-thiones are obtained as products instead of 1,3,4-oxadiazoles. A broad variety of functional groups are tolerated and a large number of substrates can be applied with this protocol. Rapid eco-friendly reactions with high yields, use of ambient temperature and water as a solvent, easy work-up procedure as well as isolation of product, excellent catalyst recyclability, high atom economy, novelty of ionic liquid as well as the protocol are the auxiliary advantages of the protocol.

ENVIROCAT EPZ-10: A SOLID ACID CATALYST FOR THE SYNTHESIS OF 1,8-DIOXO-OCTAHYDROXANTHENES IN AQUEOUS MEDIUM

An efficient method for synthesis of 1,8-dioxo-octahydroxanthenes using EPZ-10 as a heterogeneous catalyst is developed. In this method, aldehydes and dimedone / cyclohexane-1,3-dione are heated at 70 °C in the presence of a catalytic amount of EPZ-10 in water as a universal solvent, affording the corresponding 1,8-dioxo-octahydroxanthenes in moderate to excellent yields. Also, domino Knoevenagel / hetero-Michael-addition reaction is described in water without any catalyst with excellent yields. The major advantages of this method are excellent yields, short reaction time, and ease of operation. This green protocol works well with dimedone as well as cyclohexane-1,3-dione.

Potassium phosphate catalyzed nitroaldol reaction

Abstract Potassium phosphate was found to catalyze condensation of nitroalkanes with various aliphatic and aromatic aldehydes to form nitroaldols in excellent yields in acetonitrile medium at room temperature.

Trichloroisocyanuric Acid–Mediated One-Pot Synthesis of Unsymmetrical 2,5-Disubstituted 1,3,4-Oxadiazoles at Ambient Temperature

Abstract An efficient method for the one-pot synthesis of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles has been developed using trichloroisocyanuric acid (TCCA) at ambient temperature. A wide variety of aromatic as well as heterocyclic aldehydes exhibit condensation with a variety of acylhydrazines followed by oxidative cyclization to yield corresponding unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles. The mild nature of the synthesis and short reaction time are notable advantages of the developed protocol.

Dicationic 1,3-Bis(1-methyl-1H-imidazol-3-ium) Propane Copper(I) Dibromate : Novel Heterogeneous Catalyst for 1,3-Dipolar Cycloaddition

Abstract We disclose synthesis of a novel dicationic 1,3-bis(1-methyl-1H-imidazol-3-ium) propane copper(I) dibromate [Bis-(MIM)](CuBr2)] and explored its potential as a heterogeneous catalyst in 1,3-dipolar cycloaddition for regioselective synthesis of 1, 4-disubstituted-1,2,3- triazoles in excellent yields in ethanol: water (60:40%) system at 80°C. The noteworthy feature of the protocol includes in situ generation of aryl azides by azotisation of aryl as well as alkyl halides with sodium azide thereby enduring facile 1,3-dipolar cycloaddition with terminal alkynes.Graphical Abstract

Sulfamic acid as energy efficient catalyst for synthesis of flurophores, 1-H-spiro [isoindoline-1,2′-quinazoline]-3,4′(3′H)-diones

AbstractAn energy efficient synthesis of 1-H-spiro[isoindoline-1,2 ′-quinazoline]-3,4 ′(3 ′H)-diones has been expediently accomplished by a reaction of isatin(s) / cyclic ketone and anthranilamide in ethanol at ambient temprature. Excellent yields of the products in short time duration, operational simplicity, and simple work-up procedure are the attractive features of the present protocol. Synthesized 1-H-spiro[isoindoline-1,2 ′-quinazoline]-3,4 ′(3 ′H)-diones were found to be fluorescent with absorption in UV region (302, 362 nm) and emission in visible region (413-436 nm) with Stokes shift of 44-72 nm. Graphical AbstractSynthesis of 1-H-spiro [isoindoline-1,2’-quinazoline]-3,4’(3’H)-diones

Green Aspect for Multicomponent Synthesis of Spiro[4H-indeno[1,2-b]pyridine-4,3′-[3H]indoles]

Abstract An efficient, four-component reaction of isatin, 1,3-indanedione, ethyl acetoacetate, and ammonium acetate in ethanol/water (9:1) system furnished spiro[4H-indeno[1,2-b]pyridine-4,3′-[3H]indoles] at room temperature. Merits of the method are mild reaction conditions, simple workup procedure, and ambient temperature. The synthesized compounds exhibit excellent fluorescence properties. GRAPHICAL ABSTRACT

A polymer supported ascorbate functionalized task specific ionic liquid: an efficient reusable catalyst for 1,3-dipolar cycloaddition

A novel polymer supported ascorbate functionalized task specific ionic liquid was designed and synthesized. It has been demonstrated that the synthesized polymer supported ionic liquid acts as an efficient catalyst for regioselective Huisgen 1,3-dipolar cycloaddition of aryldiazonium tetrafluoroborate, sodium azide and terminal alkyne, which provide a series of 1,4-disubstituted-1,2,3-triazoles in high yields at room temperature as well as showing an aptitude for in situ incorporation of copper.