Nilgun Kalaycioglu Ozpozan

Thermal studies of p-toluidino-p-chlorophenylglyoxime and of some corresponding Ni(II), Cu(II) and Co(II) complexes

Abstract The thermal behaviour of p -toluidino- p -chlorophenylglyoxime ( p T p CPG) and its Cu(II), Ni(II), and Co(II) complexes have been studied by DTA and TG. It was found that pyrolytic decomposition undergoes with melting in both ligand and its metal complexes and metal oxides remained as end products of the metal complexes. The ligand decomposes in two stages through two different mechanisms and the metal chelates undergo decomposition in three stages. GC–MS combined system was used to identify the products during pyrolytic decompositions. The pyrolytic end products were identified by X-ray powder diffraction.

Thermal behaviours of Co(II), Ni(II), Cu(II)), and Pb(II) complexes of N,N-dipropyl-N′-benzoylthiourea

Abstract The Co(II), Ni(II), Cu(II)), and Pb(II) complexes of N,N-dipropyl-N′-benzoylthiourea (DPBT) are synthesised. The order, the activation energies, the entropies, and the pre-exponential factors of the thermal decomposition reactions are calculated with the thermogravimetric curves. The kinetic analysis of the thermogravimetric data was performed by using the Coats–Redfern and Horowitz–Metzger methods.

Kinetic analysis of thermogravimetric data of p-toluidino-p-chlorophenylglyoxime and of some complexes

Abstract Thermogravimetric (TG) and derivative thermogravimetric (DTG) investigations of p -toluidino- p -chlorophenylglyoxime ( p -T- p -CPG) and of some complexes (Co(II), Ni(II), and Cu(II)) in dynamic nitrogen atmosphere have been studied to determine their modes of decomposition. All the complexes showed similar TG behaviour. The mass losses in the main decomposition stage indicated conversion of the metal complexes to its oxide. A gas chromatography–mass spectrometry (GC–MS) combined system was used to identify the products during pyrolytic decompositions. The final products of the decompositions were identified by X-ray powder diffraction method. The kinetic parameters (energy, entropy of activation and pre-exponential factor) were calculated from the data of TG curves.

Synthesis and pro-apoptotic effects of new sulfonamide derivatives via activating p38/ERK phosphorylation in cancer cells

Abstract Herein, the compounds bearing sulfonamide fragment such as N-(2-amino-5-benzoylphenyl)-4-nitrobenzene sulfonamide hydrochloride (1), N-(quinolin-8-yl)-4-nitro-benzenesulfonamide hydrochloride (2), N-(pyridine-2-ylmethyl)-4-nitro-benzenesulfonamide hydrochloride (3) were synthesized by the reaction of 3,4-diaminobenzophenone, 8-aminoquinoline or 2-picoylamine and 4-nitrobenzensulfonyl chloride, respectively. The structures of the newly synthesized compounds were elucidated on the basis of elemental and spectral analyses. All the prepared compounds were evaluated for their in vitro anti-cancer activity against various cancer cell lines and to explore the underlying molecular mechanisms involved in this process. In vitro cytotoxic activities of the compounds were screened against human hepatocellular (HepG2), breast (MCF-7) and colon (Colo-205) cancer cell lines by MTT assay, mRNA expression of genes with qPCR and phosphorylation of p38 and ERK1/2 with Western blot. Tested compounds could significantly reduce cell proliferation and induced mRNA expression of pro-apoptotic genes; caspase 3, caspase 8 and caspase 9. Activation of these apoptotic genes probably is mediated by activation of p38.

Potential anti-inflammatory effect of water-soluble sulfonamido compounds on lipopolysaccharide-stimulated macrophage-like cellular systems

The present study was designed to investigate the potential anti-inflammatory effects and mechanisms of water-soluble sulfonamido compounds such as Sodium-N-(2-amino-5-benzoylphenyl)-4-n-propyl-benzenesulfonamido (1), Sodium-N-(2-amino-5-benzoylphenyl)-2,4,6-trimethyl-benzenesulfonamido (2), Sodium-N-(2-amino-5-benzoylphenyl)-4-chloro-benzenesulfonamido (3) and Sodium-N-(2-amino-5-benzoylphenyl)-4-methoxy-benzenesulfonamido (4) in Raw 267.4 macrophages and BV-2 microglia cells. Compounds (1–4) identities are characterized by various methods such as 1H-NMR, 13C-NMR, FT-IR, UV–Vis, cyclic voltammetry and elemental analysis. Cytotoxicity (MTT method) and production of cytokines were determined with ELISA. Furthermore, intracellular mitogen-activated protein kinase (MAPK) signaling pathway and cyclooxygenase-2 (Cox-2) expression were analyzed by Western blot. Lowest cytotoxicity was seen in compound 4 treated cells. The compound 4 inhibited lipopolysaccharide-stimulated Cox-2 expression and p38/ERK MAPK pathway in both cell lines. In addition, the inhibitory action of compound 4 not only restricted Cox-2 and p38/ERK MAPKs, but also inhibited the secretion of pro-inflammatory cytokines TNF-α/IL-6 and activated anti-inflammatory cytokine IL-10. The experimental results suggest the anti-inflammatory action of water-soluble sulfonamido compounds on activated macrophage-like cellular systems, which could be used as a future therapeutic agent in the management of chronic inflammatory diseases.

Fabrication of MgAl2Si2O8 : M0.01 (M = Ni2+, Cu2+, Pd2+, Pt2+ and Ru3+): catalytic effects for the reduction of 2- or 4-nitroanilines in water

Five new MgAl2Si2O8 : M0.01 (M = Ni2+, Cu2+, Pd2+, Pt2+ and Ru3+) materials were developed for the reduction of nitroarenes as catalysts by conventional solid state reaction at 1300∘C. The prepared materials were characterized by thermal analysis, Fourier transform infrared spectroscopy, X-ray powder diffraction analysis, scanning electron microscopy, energy-dispersive X-ray analysis and nitrogen adsorption–desorption analysis. The catalytic activities of the prepared catalysts were tested in the reduction of 2- or 4-nitroanilines in aqueous media at ambient temperature in the presence of NaBH4 by UV–vis spectrophotometer. Furthermore, the MgAl2Si2O8 : M0.01 catalysts can be recovered by filtration and reused for five cycles for the reduction of 2-nitroaniline. These results show that the MgAl2Si2O8 : M0.01 catalysts can be used in practical applications in the reduction of nitroanilines.

1-Amino-5-(4-methyl-benzo-yl)-4-(4-methyl-phen-yl)pyrimidin-2(1H)-one.

In the title compound, C19H17N3O2, the dihedral angles between the pyrimidine ring and the two benzene rings are 34.87 (12) (for the directly-bonded ring) and 69.57 (12)°. An intramolecular N—H⋯O hydrogen bond occurs. The crystal packing features intermolecular N–H⋯O hydrogen bonds.