Nobuhiro Ohkohchi
Hitachi
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Featured researches published by Nobuhiro Ohkohchi.
Annals of Surgical Oncology | 2003
Takeshi Todoroki; Naoto Koike; Yukio Morishita; Toru Kawamoto; Nobuhiro Ohkohchi; Junichi Shoda; Yoshiharu Fukuda; Hideto Takahashi
Background:Curative resection does not always equate with long-term survival. The aim was to identify patterns and predictors of failure and independent factors of prognosis after curative resection.Methods:Sixty-six patients with ampullary carcinoma who underwent surgical intervention were reviewed. Fifty-nine patients underwent pancreaticoduodenectomy. Cox regression analysis, log-rank test, Fisher exact test, or χ2 test was used.Results:No patient died as a result of surgery; major complications occurred in three, and the 5-year survival rate after curative resection (n = 55) was 52.6%. Significant survival predictors were preoperative serum carcinoembryonic antigen level; gross tumor appearance; tumor, node, and tumor node metastasis stage; and microscopic lymphatic vessel and venous invasion in the primary tumor. Multivariate analysis demonstrated that lymphatic vessel invasion, tumor, and tumor node metastasis stage were significant independent prognostic factors. No patient experienced locoregional failure alone; all 24 relapsed patients had distant failure, and six of them had both. The liver was the most frequent metastatic organ, followed by nodes, peritoneum, lung, and bone. The carcinoembryonic antigen and carbohydrate antigen levels and lymphatic vessel and venous invasion were significant predictors of distant failure, and the mean time to relapse was 13 (range, 0.7–33) months.Conclusions:Curative resection is associated with significant survival; however, effective systemic adjuvant therapy is needed to prevent distant failure for patients with elevated carcinoembryonic antigen and carbohydrate antigen levels or positive lymphatic vessel or venous invasion. A 3-year follow-up period would be necessary to document relapses.
The Japanese Journal of Gastroenterological Surgery | 2013
Osamu Shimomura; Kiyoshi Fukunaga; Yoritaka Nakano; Takeshi Nowatari; Akihiko Kobayashi; Tatsuya Oda; Ryoko Sasaki; Kenji Yamada; Masayuki Noguchi; Nobuhiro Ohkohchi
Gastrointestinal Tumors | 2017
Ryoichi Miyamoto; Yukio Oshiro; Ken Nakayama; Nobuhiro Ohkohchi
World Journal of Surgical Procedures | 2013
Kazuhiro Takahashi; Soichiro Murata; Nobuhiro Ohkohchi
The Japanese Journal of Gastroenterological Surgery | 2016
Akihiro Hara; Kiyoshi Fukunaga; Keisuke Kohno; Shinji Hashimoto; Tatsuya Oda; Masato Sugano; Masayuki Noguchi; Takahiro Konishi; Katsuhiro Nasu; Nobuhiro Ohkohchi
The Japanese Journal of Gastroenterological Surgery | 2015
Naoki Sano; Kazuhiko Yanagisawa; Kenichi Iwasaki; Ryoichi Miyamoto; Soichiro Murata; Satoshi Inagawa; Hideo Terashima; Nobuhiro Ohkohchi; Noriyuki Nakano
The Japanese Journal of Gastroenterological Surgery | 2015
Yuki Inagaki; Kiyoshi Fukunaga; Shinji Hashimoto; Keisuke Kohno; Tatsuya Oda; Nobuhiro Ohkohchi
Archive | 2014
Soichiro Murata; Risa Shiragami; Keiji Koda; Nobuhiro Ohkohchi
Archive | 2013
Tatsuya Oda; Yukio Nagasaki; Kei Asai; Eiji Kita; Hideto Yanagihara; Nobuhiro Ohkohchi; Mikio Kishimoto
The Japanese Journal of Gastroenterological Surgery | 2012
Sugiru Pak; Kiyoshi Fukunaga; Akihiko Kobayashi; Tatsuya Oda; Soichiro Murata; Ryoko Sasaki; Nobuhiro Ohkohchi