Nobuko Ito
University of Tokyo
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Featured researches published by Nobuko Ito.
Molecular Pain | 2015
Miho Asahara; Nobuko Ito; Takehiko Yokomizo; Motonao Nakamura; Takao Shimizu; Yoshitsugu Yamada
BackgroundLeukotriene B4 (LTB4) is a potent lipid mediator of inflammation, and its biological effects are mediated primarily through the high affinity LTB4 receptor BLT1. Although numerous studies have reported that LTB4-BLT1 signaling is involved in inflammatory diseases, the role of BLT1 signaling in pain remains undefined. To clarify the role of LTB4-BLT1 signaling in acute inflammatory pain induced by tissue injury, we performed pain behavioral analysis and assessment of local inflammation induced by peripheral formalin injections in BLT1 knockout mice. We examined the phosphorylation of cAMP response element-binding protein (CREB) in the spinal cord both in wild-type and BLT1 knockout mice because phosphorylation of CREB in spinal cord neurons is important for nociceptive sensitization following peripheral injury. We also examined the effect of a BLT1 antagonist on formalin-induced pain responses in mice.ResultsBLT1 knockout mice exhibited markedly attenuated nociceptive responses induced by intraplantar formalin injections. Edema formation and neutrophil infiltration in the paw were significantly decreased in BLT1 knockout mice compared with wild-type mice. Phosphorylation of CREB in the spinal cord after the intraplantar formalin injection was decreased in BLT1 knockout mice. In addition, mice pretreated with a BLT1 antagonist showed reduced nociception and attenuated CREB phosphorylation in the spinal cord after the formalin injection.ConclusionsOur data suggest that LTB4-BLT1 axis contributes not only to the peripheral inflammation but also to the neuronal activation in the spinal cord induced by intraplantar formalin injections. Thus, LTB4-BLT1 signaling is a potential target for therapeutic intervention of acute and persistent pain induced by tissue injury.
A & A case reports | 2015
Taro Kariya; Nobuko Ito; Takayuki Kitamura; Yoshitsugu Yamada
Decompensated hepatic failure occurred in a patient with a rare blood type. The patient had extreme hemodilution due to massive bleeding during liver transplantation. A shortage of matched and universal donor blood prompted us to transfuse albumin and fresh frozen plasma for intravascular volume resuscitation. The lowest hemoglobin was 0.6 g/dL, accompanied by ST depression and a serum lactate of 100 mg/dL. The accuracy of the measured value of 0.6 g/dL was confirmed. However, the patient recovered from this critical situation after transfusion, and he was eventually discharged from the hospital without significant sequelae. Maintaining normovolemia, administering pure oxygen, ensuring appropriate anesthetic depth, and maintaining minimal inotropic support were essential for this patient’s survival during massive bleeding.
Asian Cardiovascular and Thoracic Annals | 2010
Tomohiro Murakawa; Nobuko Ito; Takeshi Fukami; Jun Nakajima; Shinichi Takamoto
A 48-year-old man underwent resection of a right upper lobe necrotic tumor and part of his chest wall. Lobe-selective bronchial blockade of bleeding from the right upper lobe was achieved by combining a left-side double-lumen endotracheal tube with a bronchial blocker placed at the right intermediate bronchus. The bleeding right upper lobe was isolated, and the other lobes were protected from blood contamination during the lobectomy procedure.
Journal of Biological Chemistry | 2002
Nobuko Ito; Takehiko Yokomizo; Takehiko Sasaki; Hiroshi Kurosu; Josef M. Penninger; Yasunori Kanaho; Toshiaki Katada; Kazuo Hanaoka; Takao Shimizu
Biochemical and Biophysical Research Communications | 1997
Masao Iwamori; Yuriko Iwamori; Nobuko Ito
Journal of Biochemistry | 1998
Nobuko Ito; Yuriko Iwamori; Kazuo Hanaoka; Masao Iwamori
Journal of Clinical Gastroenterology | 2005
Masao Iwamori; Hiroko Suzuki; Nobuko Ito; Yuriko Iwamori; Kazuo Hanaoka
Journal of Biochemistry | 1999
Masao Iwamori; Yuriko Iwamori; Nobuko Ito
Translational Research | 2006
Nobuko Ito; Keiko Hirota; Kanako Momoeda; Masao Iwamori
The Journal of Urology | 2018
Shigenori Kakutani; Hiroshi Fukuhara; Fumiyuki Araki; Masaaki Asamoto; Nobuko Ito; Makoto Aihara; Haruki Kume