Nobuo Hirota
Showa University
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Publication
Featured researches published by Nobuo Hirota.
Journal of Cancer Research and Clinical Oncology | 1997
Masataka Iida; Shigeki Sunaga; Nobuo Hirota; Kuribayashi N; Hiroshi Sakagami; Minoru Takeda; Kiyoshi Matsumoto
Abstract The relation between the intracellular glutathione (GSH) concentration and hydrogen-peroxide(H2O2)-induced cytotoxicity was investigated. The intracellular GSH concentration in human glioblastoma (T98G, U87MG) and glioma (KG1C) cell lines was one or two orders of magnitude higher than that in a human myelogenous leukemic cell line (HL-60), which showed higher sensitivity to H2O2. Pretreatment of these cell lines with l-buthionine-[S,R]-sulfoximine, which significantly reduced the intracellular GSH concentration, increased their sensitivity against H2O2, whereas pretreatment with N-acetyl-l-cysteine, which did not significantly change the intracellular GSH concentration, only marginally protected the cells from the cytotoxic effect of H2O2. The results suggest that drug sensitivity of tumor cells can be modified by glutathione-modulating compounds.
Journal of Neurosurgery | 1999
Nobuo Hirota; Junji Ueno; Hiromichi Naitoh; Ken Sugiyama; Hideharu Karasawa; Hiroshi Kin; Kazumi Hatayama; Kiyoshi Matsumoto
Neurologia Medico-chirurgica | 1998
Hisato Ikeda; Hitoshi Izumiyama; Nobuo Hirota; Takumi Abe; Kiyoshi Matsumoto
Clinical Neurophysiology | 2001
Hideharu Karasawa; Koji Sakaida; Satoshi Noguchi; Kazumi Hatayama; Hiromichi Naito; Nobuo Hirota; Ken Sugiyama; Junji Ueno; Hiroshi Nakajima; Yusaku Fukada; Hiroshi Kin
Anticancer Research | 1996
Hiroshi Sakagami; Satoh K; Sugaya K; Masataka Iida; Nobuo Hirota; Kiyoshi Matsumoto; Kimura S; Kunihide Gomi; Taguchi S; Kato S; Minoru Takeda
Anticancer Research | 1997
Hiroshi Sakagami; Satoh K; Kunihiko Fukuchi; Kadofuku T; Kunihide Gomi; Nakamura K; Kuribayashi N; Shigeki Sunaga; Nobuo Hirota; Masataka Iida; Yoshiaki Makino; Kojima T; H Shimura; Minoru Takeda
Anticancer Research | 1998
Nobuo Hirota; Kiyoshi Matsumoto; Masataka Iida; Hiroshi Sakagami; Minoru Takeda
Nihon Kyukyu Igakukai Zasshi | 2001
Junji Ueno; Ken Sugiyama; Hiromichi Naitou; Nobuo Hirota; Hiroshi Kin; Hideharu Karasawa
The Showa University Journal of Medical Sciences | 1999
Nobuo Hirota; Kiyoshi Matsumoto; Shigeki Sunaga; Masataka Iida; Hiroshi Sakagami; Minoru Takeda; Seiji Shioda; Yasumitsu Nakai
The Showa University Journal of Medical Sciences | 1998
Shigeki Sunaga; Masataka Iida; Nobuo Hirota; Seiji Shioda; Hiroshi Sakagami; Minoru Takeda; Kiyoshi Matsumoto
