Shigeki Sunaga
Showa University
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Publication
Featured researches published by Shigeki Sunaga.
Journal of Cancer Research and Clinical Oncology | 1997
Masataka Iida; Shigeki Sunaga; Nobuo Hirota; Kuribayashi N; Hiroshi Sakagami; Minoru Takeda; Kiyoshi Matsumoto
Abstract The relation between the intracellular glutathione (GSH) concentration and hydrogen-peroxide(H2O2)-induced cytotoxicity was investigated. The intracellular GSH concentration in human glioblastoma (T98G, U87MG) and glioma (KG1C) cell lines was one or two orders of magnitude higher than that in a human myelogenous leukemic cell line (HL-60), which showed higher sensitivity to H2O2. Pretreatment of these cell lines with l-buthionine-[S,R]-sulfoximine, which significantly reduced the intracellular GSH concentration, increased their sensitivity against H2O2, whereas pretreatment with N-acetyl-l-cysteine, which did not significantly change the intracellular GSH concentration, only marginally protected the cells from the cytotoxic effect of H2O2. The results suggest that drug sensitivity of tumor cells can be modified by glutathione-modulating compounds.
Endocrine Journal | 2001
Takumi Abe; Yoshiharu Sawabe; Yubuhito Mochizuki; Shigeki Sunaga; Hitoshi Izumiyama; Kiyoshi Matsumoto; Miki Kushima; Matsuo Taniyama; Yoshio Ban; Toshiaki Sano
Anticancer Research | 1997
Hiroshi Sakagami; Satoh K; Kunihiko Fukuchi; Kadofuku T; Kunihide Gomi; Nakamura K; Kuribayashi N; Shigeki Sunaga; Nobuo Hirota; Masataka Iida; Yoshiaki Makino; Kojima T; H Shimura; Minoru Takeda
No shinkei geka. Neurological surgery | 1999
Takumi Abe; Kiyoshi Matsumoto; Motohiko Shimazu; Jimbo H; Shigeki Sunaga; Dohi K; Ken Sasaki; Hitoshi Izumiyama; Ohki S; Fujitani S
Nō to shinkei Brain and nerve | 1999
Takumi Abe; Kiyoshi Matsumoto; Shigeki Sunaga; Dohi K; Kazuo Hanakawa; Motohiko Shimazu; Jimbo H; Ken Sasaki; Hitoshi Izumiyama; Miki Kushima
Surgery for Cerebral Stroke | 1997
Hiroyuki Jimbo; Takanobu Iwata; Hisato Ikeda; Shigeki Sunaga; Kazuo Hanakawa; Masataka Iida; Ken Sasaki; Hitoshi Izumiyama; Hidekatsu Mizushima; Kiyoshi Matsumoto
Surgery for Cerebral Stroke | 1998
Hisato Ikeda; Takanobu Iwata; Kazuo Hanakawa; Kenji Dohi; Shigeki Sunaga; Hiroyuki Jinbo; Ken Sasaki; Qing Lan; Takumi Abe; Toshio Moroboshi; Michio Akima; Kiyoshi Matsumoto
The Showa University Journal of Medical Sciences | 1999
Nobuo Hirota; Kiyoshi Matsumoto; Shigeki Sunaga; Masataka Iida; Hiroshi Sakagami; Minoru Takeda; Seiji Shioda; Yasumitsu Nakai
The Showa University Journal of Medical Sciences | 1998
Shigeki Sunaga; Masataka Iida; Nobuo Hirota; Seiji Shioda; Hiroshi Sakagami; Minoru Takeda; Kiyoshi Matsumoto
Japanese Journal of Neurosurgery | 1997
Hisato Ikeda; Kazuo Hanakawa; Kenji Dohi; Shigeki Sunaga; Nobuo Hirota; Yasuhiro Suzuki; Takanobu Iwata; Kiyoshi Matsumoto
