Nobutaka Hattori
Wolfson Centre for Age-Related Diseases
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Publication
Featured researches published by Nobutaka Hattori.
Journal of Biological Chemistry | 2002
Dong-Hoon Hyun; MoonHee Lee; Nobutaka Hattori; Shin-Ichiro Kubo; Yoshikuni Mizuno; Barry Halliwell; Peter Jenner
Mutations in Parkin (a ubiquitin protein ligase) are involved in autosomal recessive juvenile parkinsonism, but it is not known how they cause nigral cell death. We examined the effect of Parkin overexpression on cellular levels of oxidative damage, antioxidant defenses, nitric oxide production, and proteasomal enzyme activity. Increasing expression of Parkin by gene transfection in NT-2 and SK-N-MC cells led to increased proteasomal activity, decreased levels of protein carbonyls, 3-nitrotyrosine-containing proteins, and a trend to a reduction in ubiquitinated protein levels. Transfection of these cells with DNA encoding three mutant Parkins associated with autosomal recessive juvenile parkinsonism (Del 3–5, T240R, and Q311X) gave smaller increases in proteasomal activity and led to elevated levels of protein carbonyls and lipid peroxidation. Turnover of the mutant proteins was slower than that of the wild-type protein, and both could be blocked by the proteasome inhibitor, lactacystin. A rise in levels of nitrated proteins and increased levels of NO 2 − /NO 3 − was also observed in cells transfected with mutant Parkins, apparently because of increased levels of neuronal nitric-oxide synthase. The presence of mutant Parkin in substantia nigra in juvenile parkinsonism may increase oxidative stress and nitric oxide production, sensitizing cells to death induced by other insults.
Archive | 2002
Nobutaka Hattori; Yuzuru c; o Riken Imai; Haruhisa c; o Riken Inoue; Yoshikuni Mizuno; Mariko c; o Riken Soda; Ryosuke c; o Riken Takahashi
Juntendo Medical Journal | 2001
Nobutaka Hattori; Yoshikuni Mizuno
The Japanese Biochemical Society/The Molecular Biology Society of Japan | 2017
Kahori Shiba; Tsuyoshi Inoshita; Yuko Aoki; Yashushi Ishihama; Yuzuru Imai; Nobutaka Hattori
The Japanese Biochemical Society/The Molecular Biology Society of Japan | 2017
Taku Arano; Yuzuru Imai; Nobutaka Hattori
The Japanese Biochemical Society/The Molecular Biology Society of Japan | 2017
Tsuyoshi Inoshita; Taku Arano; Yuka Hosaka; Hongrui Meng; Yujiro Umezaki; Sakiko Kosugi; Takako Morimoto; Masato Koike; Hui-Yun Chang; Yuzuru Imai; Nobutaka Hattori
順天堂醫事雑誌 = Juntendo medical journal | 2014
Taku Hatano; Nobutaka Hattori
Archive | 2014
Taku Hatano; Shin-Ichiro Kubo; Nobutaka Hattori; Yoshikuni Mizuno
Archive | 2010
Kazuhiro Iwai; 一宏 岩井; Nobutaka Hattori; 信孝 服部; Shin-ichi Sakata; 真一 坂田
Blue Books of Neurology | 2010
Nobutaka Hattori; Taku Hatano; Yutaka Machida; Shigeto Sato; Shin-Ichiro Kubo