Nobuyuki Ohkawa

AgOTfaSnCl4: A powerful new promoter combination in the aryl C-glycosidation of a diverse range of sugar acetates and aromatic substrates

SnCl4AgOTfa was shown to be a powerful combination for promoting aryl C-glycosidation between various sugar acetates and aromatic substrates. This promoter activates otherwise unreactive peracetylated glycosides, leaving them susceptible to reaction with low electron-donating aromatics. A survey of the reaction application is described.

Tetrahydropyridine derivatives with inhibitory activity on the production of proinflammatory cytokines: Part 1

We investigated proinflammatory cytokine TNFalpha production inhibitors in order to develop novel anti-inflammatory agents. According to the results, we found that 17, a pyrrole derivative possessing a tetrahydropyridine group at the beta-position, showed potent inhibitory activity in vitro (inhibition of lipopolysaccharide (LPS) induced TNFalpha production in human whole blood, IC(50)=1.86 microM) and in vivo (inhibition of LPS induced TNFalpha production in mice, ID(50)=5.98 mg/kg).

Aryl C-glycosides: physiologically stable glycomimetics of sialyl Lewis X.

In the course of the search for physiologically stable, structurally simple, and low molecular weight sLeX mimetics, aryl C-glycosides with carboxylic acid functionality 2 were found to be extremely potent inhibitors against L- and P-selectins with IC50 in the low microM range.

The sequential double aryl C-glycosidation: Introduction of a second sugar unit onto mono aryl C-glycosides using

Abstract The promoter combination ( SnCl 4 AgOTfa ) was successfully applied to introduce a second sugar unit onto mono aryl C-glycosides. A systematic survey of this sequential double aryl C-glycosidation is described.