Takayoshi Nagasaki
Daiichi Sankyo
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Publication
Featured researches published by Takayoshi Nagasaki.
Bioorganic & Medicinal Chemistry Letters | 2010
Akira Nakao; Nobuyuki Ohkawa; Takayoshi Nagasaki; Takashi Kagari; Hiromi Doi; Takaichi Shimozato; Shigeru Ushiyama; Kazumasa Aoki
We investigated proinflammatory cytokine TNFalpha production inhibitors in order to develop novel anti-inflammatory agents. According to the results, we found that 17, a pyrrole derivative possessing a tetrahydropyridine group at the beta-position, showed potent inhibitory activity in vitro (inhibition of lipopolysaccharide (LPS) induced TNFalpha production in human whole blood, IC(50)=1.86 microM) and in vivo (inhibition of LPS induced TNFalpha production in mice, ID(50)=5.98 mg/kg).
Archive | 2003
Tomio Kimura; Akira Nakao; Nobuyuki Ohkawa; Takayoshi Nagasaki; Takanori Yamazaki
Archive | 2004
Tomio Kimura; Nobuyuki Ohkawa; Akira Nakao; Takayoshi Nagasaki; Takaichi Shimozato
Archive | 2002
Tomio Kimura; Nobuyuki Ohkawa; Akira Nakao; Takayoshi Nagasaki; Takanori Yamazaki
Archive | 2005
Tomio Kimura; Nobuyuki Ohkawa; Kazumasa Aoki; Akira Nakao; Takayoshi Nagasaki
Archive | 2006
Tomio Kimura; Nobuyuki Ohkawa; Takayoshi Nagasaki; Atsuhiro Sugidachi; Osamu Ando
Archive | 2011
Nobuyuki Ohkawa; Kouki Iida; Takayoshi Nagasaki
Archive | 2011
Nobuyuki Ohkawa; Kouki Iida; Takayoshi Nagasaki
Archive | 2011
Nobuyuki Ohkawa; Kouki Iida; Takayoshi Nagasaki
Archive | 2011
Nobuyuki Ohkawa; Kouki Iida; Takayoshi Nagasaki
