Norio Minami | Researchain

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Featured researches published by Norio Minami.

Bioorganic & Medicinal Chemistry Letters | 1994

Discovery and development of aryl-fused imidazole-based angiotensin II antagonists

Kazutoshi Miyake; Masayuki Matsukura; Naoki Yoneda; Osamu Hiroshima; Nobuyuki Mori; Hiroki Ishihara; Takashi Musha; Toshiyuki Matsuoka; Tadao Shoji; Norio Minami; Sachiyuki Hamano; Isao Saito

Abstract A phenolic benzofuran derivative 1 was identified as an angiotensin II receptor antagonist by random screening. Structural modifications led to a novel series of N-(4-hydroxyphenylmethyl)benzimidazoles and imidazo[4,5-b]pyridines, some of which inhibited angiotensin II-induced contractions in rabbit aortic strips with pA2 values of nearly 9. The related biphenylmethyl derivative E4177 showed potent and long-lasting activity in vivo.

Archive | 1990

Biphenylmethane derivative, the use of it and pharmacological compositions containing same

Kazutoshi Miyake; Masayuki Matsukura; Naoki Yoneda; Osamu Hiroshima; Nobuyuki Mori; Hiroki Ishihara; Takashi Musha; Toshiyuki Matsuoka; Sachiyuki Hamano; Norio Minami

Journal of Medicinal Chemistry | 1991

SYNTHESIS AND BIOLOGICAL EVALUATION OF SUBSTITUTED BENZENESULFONAMIDES AS NOVEL POTENT MEMBRANE-BOUND PHOSPHOLIPASE A2 INHIBITORS

Hitoshi Oinuma; Tadanobu Takamura; Takashi Hasegawa; Kenichi Nomoto; Toshihiko Naitoh; Yoshiharu Daiku; Sachiyuki Hamano; Hiroshi Kakisawa; Norio Minami

Synthesis | 1996

SYNTHESIS OF (2R)-1-(4-CHLORO-2-PYRIDYL)-2-(2-PYRIDYL)ETHYLAMINE : A SELECTIVE OXIME REDUCTION AND CRYSTALLIZATION-INDUCED ASYMMETRIC TRANSFORMATION

Shigeto Negi; Masayuki Matsukura; Masanori Mizuno; Kazutoshi Miyake; Norio Minami

Chemical & Pharmaceutical Bulletin | 1992

Synthesis and Antiarrhythmic Activity of 2,2-Dialkyl-1'-(N-substituted aminoalkyl)-spiro-[chroman-4,4'-imidazolidine]-2', 5'-diones

Masayuki Matsukura; Yoshiharu Daiku; Kouichirou Ueda; Satoru Tanaka; Toshiji Igarashi; Norio Minami

Archive | 1995

Process for the preparation of .alpha.-tocopherol

Noriyasu Hirose; Hiroshi Inoue; Toshio Matsunami; Takashi Yoshimura; Kouzou Morita; Yuh Horikawa; Noriyoshi Iwata; Norio Minami; Kenji Hayashi; Chiaki Seki

Archive | 1989

Butenoic or propenoic acid derivative

Norio Minami; Fumihiro Ozaki; Keiji Ishibashi; Yasuhiro Kabasawa; Megumi Ikemori; Toshiaki Ogawa; Takanori Kawamura

Archive | 1987

Piperidine derivative and pharmaceutical composition containing the same

Hitoshi Oinuma; Motosuke Yamanaka; Kazutoshi Miyake; Tomonori Hoshiko; Norio Minami; Tadao Shoji; Yoshiharu Daiku; Kohei Sawada; Kenichi Nomoto

Archive | 1995

Biphenylderivatives, process for their preparation and their use as medicaments

Kozo Akasaka; Masahiro Yonaga; Akiharu Kajiwara; Kunizo Higurashi; Kohshi Ueno; Satoshi Nagato; Makoto Komatsu; Noritaka Kitazawa; Masataka Ueno; Yoshiharu Yamanishi; Yoshimasa Machida; Yuki Komatsu; Naoyuki Shimomura; Norio Minami; Toshikazu Shimizu; Atsushi Nagaoka

Archive | 1987