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Toxins | 2010

Natural Toxins for Use in Pest Management

Stephen O. Duke; Charles L. Cantrell; Kumudini M. Meepagala; David E. Wedge; Nurhayat Tabanca; Kevin K. Schrader

Natural toxins are a source of new chemical classes of pesticides, as well as environmentally and toxicologically safer molecules than many of the currently used pesticides. Furthermore, they often have molecular target sites that are not exploited by currently marketed pesticides. There are highly successful products based on natural compounds in the major pesticide classes. These include the herbicide glufosinate (synthetic phosphinothricin), the spinosad insecticides, and the strobilurin fungicides. These and other examples of currently marketed natural product-based pesticides, as well as natural toxins that show promise as pesticides from our own research are discussed.


Journal of Agricultural and Food Chemistry | 2009

Bioactivity-Guided Fractionation and GC/MS Fingerprinting of Angelica sinensis and Angelica archangelica Root Components for Antifungal and Mosquito Deterrent Activity

David E. Wedge; J. A. Klun; Nurhayat Tabanca; Betül Demirci; T. Özek; K. H.C. Baser; Zhijun Liu; Sui Zhang; Charles L. Cantrell; Jian Zhang

Bioassay-guided fractionation of the chloroform extract from the roots of Angelica sinensis led to isolation and characterization of (Z)-ligustilide using direct-bioautography with Colletotrichum species. The structure of (Z)-ligustilide was confirmed by (1)H and (13)C NMR spectroscopy and GC/MS. (Z)-Ligustilide deterred the biting of two mosquito species more effectively than DEET. Three different A. sinensis accessions and one Angelica archangelica root oil were evauated by GC and GC/MS, and the dominant component in A. sinensis was 61-69% (Z)-ligustilide. Two other prominent compounds in A. sinensis oils were 5.7-9.8% (E)-3-butylidene phthalide and 1.5-2.3% (Z)-3-butylidene phthalide. The main constituents that comprised A. archangelica oil were monoterpene hydrocarbons such as 24.5% alpha-pinene, 13.8% delta-3-carene, 10.1% beta-phellandrene, 8.8% p-cymene, 8.4% limonene, and 6.3% sabinene. Phthalides and monoterpene hydrocarbons were determined to be good systematic markers or chemical fingerprints for A. sinensis and A. archangelica root oils. Chemical fingerprinting by GC/MS of A. sinensis also confirmed the misidentification of one A. archangelica sample sold in the Chinese market.


Journal of Chromatography A | 2010

Gas chromatographic-mass spectrometric analysis of volatiles obtained by four different techniques from Salvia rosifolia Sm., and evaluation for biological activity

Gülmira Özek; Fatih Demirci; T. Özek; Nurhayat Tabanca; David E. Wedge; Shabana I. Khan; K. H.C. Baser; Ahmet Duran; Ergin Hamzaoglu

Four different isolation techniques, conventional hydrodistillation (HD), microwave-assisted hydrodistillation (MWHD), microdistillation (MD) and micro-steam distillation-solid-phase microextraction (MSD-SPME), have been used to analyze the volatile constituents from the aerial parts of Salvia rosifolia Sm. by gas chromatography and gas chromatography coupled to mass spectrometry. HD and MWHD techniques produced quantitatively (yield, 0.39% and 0.40%) and qualitatively (aromatic profile) similar essential oils. alpha-Pinene (15.7-34.8%), 1,8-cineole (16.6-25.1%), beta-pinene (6.7-13.5%), beta-caryophyllene (1.4-5.0%) and caryophyllene oxide (1.4-4.4%) were identified as major constituents of this Turkish endemic species. Besides, the hydrodistilled oil of S. rosifolia was evaluated for antibacterial, antifungal, anticancer, antioxidant and cytotoxic activities. The hydrodistilled oil of S. rosifolia showed antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA) with a MIC value of 125microg/mL. Other human pathogenic microorganisms (Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogenes, Salmonella typhimurium, Staphylococcus epidermidis, Candida albicans) were also inhibited within a moderate range (MIC=125-1000microg/mL). Antifungal activity of the oil was also observed against the strawberry anthracnose-causing fungal plant pathogens Colletotrichum acutatum, C. fragariae and C. gloeosporioides. No cytotoxicity was observed for S. rosifolia oil up to 25mg/mL against malignant melanoma, epidermal, ductal and ovary carcinoma.


Journal of Agricultural and Food Chemistry | 2011

Biological Activity of Peanut (Arachis hypogaea) Phytoalexins and Selected Natural and Synthetic Stilbenoids

Victor S. Sobolev; Shabana I. Khan; Nurhayat Tabanca; David E. Wedge; Susan P. Manly; Stephen J. Cutler; Monique R. Coy; James J. Becnel; Scott A. Neff; James B. Gloer

The peanut plant (Arachis hypogaea L.), when infected by a microbial pathogen, is capable of producing stilbene-derived compounds that are considered antifungal phytoalexins. In addition, the potential health benefits of other stilbenoids from peanuts, including resveratrol and pterostilbene, have been acknowledged by several investigators. Despite considerable progress in peanut research, relatively little is known about the biological activity of the stilbenoid phytoalexins. This study investigated the activities of some of these compounds in a broad spectrum of biological assays. Since peanut stilbenoids appear to play roles in plant defense mechanisms, they were evaluated for their effects on economically important plant pathogenic fungi of the genera Colletotrichum, Botrytis, Fusarium, and Phomopsis. We further investigated these peanut phytoalexins, together with some related natural and synthetic stilbenoids (a total of 24 compounds) in a panel of bioassays to determine their anti-inflammatory, cytotoxic, and antioxidant activities in mammalian cells. Several of these compounds were also evaluated as mammalian opioid receptor competitive antagonists. Assays for adult mosquito and larvae toxicity were also performed. The results of these studies reveal that peanut stilbenoids, as well as related natural and synthetic stilbene derivatives, display a diverse range of biological activities.


Journal of Vector Ecology | 2011

Essential oils of Cupressus funebris, Juniperus communis, and J. chinensis (Cupressaceae) as repellents against ticks (Acari: Ixodidae) and mosquitoes (Diptera: Culicidae) and as toxicants against mosquitoes

J. F. Carroll; Nurhayat Tabanca; Matthew Kramer; Natasha M. Elejalde; David E. Wedge; Ulrich R. Bernier; Monique Coy; James J. Becnel; Betül Demirci; K. H.C. Baser; Jian Zhang; Sui Zhang

ABSTRACT: Juniperus communis leaf oil, J. chinensis wood oil, and Cupressus funebris wood oil (Cupressaceae) from China were analyzed by gas chromatography and gas chromatography-mass spectrometry We identified 104 compounds, representing 66.8–95.5% of the oils. The major components were: &agr;-pinene (27.0%), &agr;-terpinene (14.0%), and linalool (10.9%) for J. communis; cuparene (11.3%) and &dgr;-cadinene (7.8%) for J. chinensis; and &agr;-cedrene (16.9%), cedrol (7.6%), and &bgr;-cedrene (5.7%) for C. funebris. The essential oils of C. funebris, J. chinensis, and J. communis were evaluated for repellency against adult yellow fever mosquitoes, Aedes aegypti (L.), host-seeking nymphs of the lone star tick, Amblyomma americanum (L.), and the blacklegged tick, Ixodes scapularis Say, and for toxicity against Ae. aegypti larvae and adults, all in laboratory bioassays. All the oils were repellent to both species of ticks. The EC95 values of C. funebris, J. communis, and J. chinensis against A. americanum were 0.426, 0.508, and 0.917 mg oil/cm2 filter paper, respectively, compared to 0.683 mg deet/cm2 filter paper. All I. scapularis nymphs were repelled by 0.103 mg oil/cm2 filter paper of C. funebris oil. At 4 h after application, 0.827 mg oil/cm2 filter paper, C. funebris and J. chinensis oils repelled ≥80% of A. americanum nymphs. The oils of C. funebris and J. chinensis did not prevent female Ae. aegypti from biting at the highest dosage tested (1.500 mg/cm2). However, the oil of J. communis had a Minimum Effective Dosage (estimate of ED99) for repellency of 0.029 ± 0.018 mg/cm2; this oil was nearly as potent as deet. The oil of J. chinensis showed a mild ability to kill Ae. aegypti larvae, at 80 and 100% at 125 and 250 ppm, respectively.


Letters in Drug Design & Discovery | 2012

Synthesis and Biological Evaluation of Some Hydrazone Derivatives as Anti-inflammatory Agents

Zafer Asım Kaplancıklı; Mehlika Dilek Altıntop; Ahmet Özdemir; Gülhan Turan-Zitouni; Shabana I. Khan; Nurhayat Tabanca

In the present study, some hydrazone derivatives were synthesized via the reaction of 3-cyclohexylpropionic acid hydrazide with various benzaldehydes. The chemical structures of the compounds were elucidated by spectroscopic techniques such as IR, 1 H-NMR and FAB-MS and elemental analyses. The compounds were evaluated for their anti- inflammatory and cytotoxic activities. Anti-inflammatory activity was determined in terms of inhibition of NF-! B, ROS generation and iNOS activity. Several derivatives inhibited NF-! B and iNOS, but no effect was observed on intracellular ROS generation. Furthermore no cytoxicity was observed. Biological activity compared with the chemical structural information suggests that different functional groups on the phenyl ring influence the physicochemical properties and thus modulate biological activity.


Molecules | 2013

Synthesis and Biological Activity of Substituted Urea and Thiourea Derivatives Containing 1,2,4-Triazole Moieties

Bedia Kocyigit-Kaymakcioglu; Ahmet Ozgur Celen; Nurhayat Tabanca; Abbas Ali; Shabana I. Khan; Ikhlas A. Khan; David E. Wedge

A series of novel thiourea and urea derivatives containing 1,2,4-triazole moieties were synthesized and evaluated for their antifungal and larvicidal activity. Triazole derivatives 3a–e and 4a–e were synthesized by reacting thiocarbohydrazide with thiourea and urea compounds 1a–e and 2a–e, respectively, in a 130–140 °C oil bath. The proposed structures of all the synthesized compounds were confirmed using elemental analysis, UV, IR, 1H-NMR and mass spectroscopy. All compounds were evaluated for antifungal activity against plant pathogens, larvicidal and biting deterrent activity against the mosquito Aedes aegypti L. and in vitro cytotoxicity and anti-inflammatory activity against some human cell lines. Phomopis species were the most sensitive fungi to these compounds. Compounds 1b, 1c, 3a and 4e demonstrated selectively good activity against Phomopis obscurans and only 1b and 4e showed a similar level of activity against P. viticola. Compound 3d, with a LD50 value of 67.9 ppm, followed by 1c (LD50 = 118.8 ppm) and 3e (LD50 = 165.6 ppm), showed the highest toxicity against Aedes aegypti larvae. Four of these compounds showed biting deterrent activity greater than solvent control, with the highest activity being seen for 1c, with a proportion not biting (PNB) value of 0.75, followed by 1e, 2b and 1a. No cytotoxicity was observed against the tested human cancer cell lines. No anti-inflammatory activity was observed against NF-κB dependent transcription induced by phorbol myristate acetate (PMA) in human chondrosarcoma cells.


Journal of Medical Entomology | 2013

Biting Deterrence, Repellency, and Larvicidal Activity of Ruta chalepensis (Sapindales: Rutaceae) Essential Oil and Its Major Individual Constituents Against Mosquitoes

Abbas Ali; Betül Demirci; Hülya Tuba Kıyan; Ulrich R. Bernier; Maia Tsikolia; David E. Wedge; Ikhlas A. Khan; K. H.C. Baser; Nurhayat Tabanca

ABSTRACT The essential oil from aerial parts of Ruta chalepensis L. (Sapindales: Rutaceae) was obtained by hydrodistillation, and its chemical profile was identified using gas chromatography and gas chromatography-mass spectrometry. Compounds, 2-undecanone (43.2%), 2-nonanone (27.9%), and 2-nonyl acetate (10.6%) were the major constituents of the oil. Biting deterrent activity of R. chalepensis essential oil at 10 and 50 µg/cm2, 2-undecanone at 8.5 µg/cm2, 2-nonanone at 9 µg/cm2, and 2-nonyl acetate at 9.3 µg/cm2 was similar to DEET (N, N-diethyl-meta-toluamide) at 4.8 µg/cm2, against Aedes aegypti L. Biting deterrent activity of R. chalepensis oil at 50 µg/cm2 against Anopheles quadrimaculatus Say was statistically similar to DEET at 4.8 µg/cm2, whereas the activity was lower in the other compounds tested. In cloth patch assay, R. chalepensis essential oil was effective at 187 µg/cm2, whereas 2-undecanone was effective at 108.9 µg/cm2 against Ae. aegypti. In larval bioassays, 2-undecanone showed similar toxicity whereas toxicity of R. chalepensis essential oil and 2-nonanone was higher at 24-h posttreatment at the LD50 in An. quadrimaculatus than Ae. aegypti. This study revealed that R. chalepensis essential oil and its major compounds were active biting deterrents against Ae. aegypti at higher application rates whereas only the essential oil showed activity similar to DEET against An. quadrimaculatus. 2-undecanone was the most active compound in in vivo repellency bioassay against Ae. aegypti. Chemical composition of R. chalepensis essential oil varies because of plant production and harvest practices, and the activity level of the essential oil may depend on the source of the sample.


Molecules | 2013

Chemical Composition, Antifungal and Insecticidal Activities of Hedychium Essential Oils

Hamidou F. Sakhanokho; Blair J. Sampson; Nurhayat Tabanca; David E. Wedge; Betül Demirci; K. H.C. Baser; Ulrich R. Bernier; Maia Tsikolia; Natasha M. Agramonte; James J. Becnel; Jian Chen; Kanniah Rajasekaran; James M. Spiers

The antimicrobial properties of essential oils have been documented, and their use as “biocides” is gaining popularity. The aims of this study were to analyze the chemical composition and assess the biological activities of Hedychium essential oils. Oils from 19 Hedychium species and cultivars were analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) techniques. The antifungal and insecticidal activities of these oils were tested against Colletotrichum acutatum, C. fragariae, and C. gloeosporioides, and three insects, the azalea lace bug (Stephanitis pyrioides), the yellow fever mosquito (Aedes aegypti), and the red imported fire ant (Solenopsis invicta). Hedychium oils were rich in monoterpenes and sesquiterpenes, especially 1,8-cineole (0.1%–42%), linalool (<0.1%–56%), α-pinene (3%–17%), β-pinene (4%–31%), and (E)-nerolidol (0.1%–20%). Hedychium oils had no antifungal effect on C. gloeosporioides, C. fragariae, and C. acutatum, but most Hedychium oils effectively killed azalea lace bugs. The oils also show promise as an adult mosquito repellent, but they would make rather poor larvicides or adulticides for mosquito control. Hedychium oils acted either as a fire ant repellent or attractant, depending on plant genotype and oil concentration.


Journal of Agricultural and Food Chemistry | 2013

Bioactivity-Guided Investigation of Geranium Essential Oils as Natural Tick Repellents

Nurhayat Tabanca; Mei Wang; Cristina Avonto; Amar G. Chittiboyina; Jon F. Parcher; John F. Carroll; Matthew Kramer; Ikhlas A. Khan

The evaluation of 10 essential oils of geranium, Pelargonium graveolens (Geraniaceae), were all shown to have repellent activity against nymphs of the medically important lone star tick, Amblyomma americanum (L.). The biological tests were carried out using a vertical filter paper bioassay, where ticks must cross an area of the paper treated with repellent to approach host stimuli. One of the essential oil samples that repelled >90% of the ticks at 0.103 mg/cm(2) was selected for further fractionation studies. The sesquiterpene alcohol, (-)-10-epi-γ-eudesmol, was isolated and identified by spectral methods. (-)-10-epi-γ-Eudesmol at 0.103 and 0.052 mg of compound/cm(2) of filter paper repelled 90 and 73.3% of the ticks, respectively. (-)-10-epi-γ-Eudesmol exhibited similar repellency to the reference standard N,N-diethyl-meta-toluamide (DEET) at concentrations of ≥0.052 mg of compound/cm(2) of filter paper, with (-)-10-epi-γ-eudesmol losing much of its repellency at 0.026 mg of compound/cm(2) and DEET at 0.013 mg of compound/cm(2). Isomenthone and linalool did not repel ticks at the concentrations tested. Most repellents are marketed with much higher concentrations of active ingredient than the concentrations of the natural repellents tested herein; therefore, effective compounds, such as (-)-10-epi-γ-eudesmol, found in geranium oil, have the potential for commercial development.

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David E. Wedge

University of Mississippi

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Ikhlas A. Khan

University of Mississippi

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Abbas Ali

University of Mississippi

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Ulrich R. Bernier

Agricultural Research Service

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James J. Becnel

Agricultural Research Service

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