O. Hromatka

Über die Synthese von substituierten 5-Phenyl-1H-thieno[2,3-e]1,4-diazepin-2(3H)-onen

The preparation of in position 6 and 7 mono- and dimethylsubstituted 5-phenyl-1H-thieno[2.3-e]1.4-diazepin-2(3H)-ones and their methylation in position 1 are described. The thienodiazepine5 b was furthermore chlorinated, brominated and nitrated in position 7.ZusammenfassungEs wird die Synthese von in Stellung 6 und 7 mono- und dimethylsubstituierten 5-Phenyl-1H-thieno[2,3-e]1,4-diazepin-2(3H)-onen und ihre Methylierung in Stellung 1 beschrieben. Das Thienodiazepin5 b wurde außerdem in Stellung 7 chloriert, bromiert und nitriert.

Über den Mechanismus derDieckmann-Reaktion von 3-(Methoxycarbonylmethylthio)-propionsäuremethylester

The mechanism of theDieckmann-reaction of methyl 3-(methoxycarbonylmethylthio)-propionate (1) to methyl 4-oxotetrahydrothiophene-3-carboxylate (2) and methyl 3-oxo-tetrahydrothiophene-2-carboxylate (3) and a simple technique for the preparation of methyl 4-oxo-tetrahydrothiophene-3-carboxylate (2) free from the isomere3 are described.

Über die Synthese von substituierten 1,3-Dihydro-5-(2-pyridyl)-thieno[2,3—e]-1,4-diazepin-2-onen

The preparation of the title substances as well as their chlorination in position 7 and methylation in position 1 are described.

Über die Synthese von 5-Phenyl-1H-thieno[3,4—e]1,4-diazepin-2(3H)-on

The synthesis of 5-phenyl-1H-thieno[3.4—e]1.4-diazepin-2(3H)-one (16), its alkylation in position 1 and the preparation of the intermediate 3-(4-aminothienyl)-phenylketone (8) are described. In addition thieno[3.4—b]pyridin-2(1H)-one (7) is described.

Über die Nitrierung von 7-Chlor-5-phenyl-1H-thieno[2,3-e]1,4-diazepin-2(3H)-on

The said compound (1) yielded a product whose structure was determined by chemical methods.ZusammenfassungBei der Nitrierung von 7-Chlor-5-phenyl-1H-thieno[2,3-e]1,4-diazepin-2(3H)-on (1) wurde ein Produkt erhalten, dessen Struktur durch chemische Beweisführung bestimmt wurde.

Über die synthese von 6,7-Dichlor-5-phenly-1H-thieno[2,3-e]-1,4-diazepin-2(3H)-on

The preparation of the said compound (2) and its methylation in position 1 are described.

Über die Synthese von substituierten Thieno[3,4—b]chinolin-9(4H)-onen

The synthesis of in position 4 substituted thieno[3.4-b]quinoline-9(4H)-ones (6) by aromatization of 1.4-dihydrothieno[3.4-b]quinoline-9(3H)-ones (4) and attempts to cyclize 4-phenylamino-3-thiophenecarboxylic acid (3c), or derivatives thereof, to compounds of type6 are described.

Über die Synthese von 5-(o-Trifluormethylphenyl)-1H-thieno[3,4—e]-1,4-diazepin-2(3H)-onen

The synthesis of 5-(o-trifluoromethylphenyl)-1H-thieno-[3,4-e]1,4-diazepin-2(3H)-one (7) and its nitration and chlorination in pos. 8 are described.

ber die Synthese von 5-(o-Chlorphenyl)-7-trifluormethyl-1Hthieno[3,2?e]-1,4-diazepin-2(3H)-on@@@5-(o-chlorophenyl)-7-trifluoromethyl-1H-thieno[3.2?e]-1.4-diazepin-2(3H)-one

The synthesis of 5-(o-chlorophenyl)-7-trifluoromethyl-1H-thieno[3.2−e]-1.4-diazepin-2(3H)-one (10) starting from ethyl 3-amino-5-trifluoromethyl-2-thiophenecarboxylate (1) is described.The synthesis of 5-(o-chlorophenyl)-7-trifluoromethyl-1H-thieno[3.2−e]-1.4-diazepin-2(3H)-one (10) starting from ethyl 3-amino-5-trifluoromethyl-2-thiophenecarboxylate (1) is described.

Über die Synthese von Amino-trifluormethyl-thiophencarbonsäureäthylestern

The syntheses of ethyl 4-amino-2-trifluormethyl-thiophene-3-carboxylate (14) and of ethyl 3-amino-5-trifluormethylthiophene-2-carboxylate (15) are described.The structures of14 and15 are confirmed by NMR-spectroscopy. TheDieckmann reaction of the important intermediate ethyl 3-(carbethoxymethylthio)-3-trifluormethyl-propionate is described.