O. Robineau

Herpes simplex virus meningoencephalitis in a patient with Crohn's disease on azathioprine therapy.

Herpes Simplex Virus Meningoencephalitis in a Patient With Crohns Disease on Azathioprine Therapy

Focus on MRSA/SA SSTI Assay Failure in Prosthetic Joint Infections: 213 Consecutive Patients Later

In prosthetic joint infection (PJI) cases ([1][1]), rapid detection of methicillin-resistant staphylococci (MRS) is the key to avoiding the use of broad-spectrum antimicrobials such as vancomycin. Indeed, vancomycin use is associated with a risk of renal impairment, a lesser efficacy against

Treatment options for diabetic foot osteomyelitis

ABSTRACT Introduction: Diabetic foot osteomyelitis therapeutical options are based on antibiotic therapy and surgical resection of the infected bone(s). Surgical and medical approaches of patients suffering from a diabetic foot osteomyelitis do not oppose but are complementary and need to be discussed as a tailored manner. Areas covered: The aim of the present article is to discuss data issued from the most recent guidelines of the Infectious Diseases Society of America and the International Working Group on the Diabetic Foot on the management of the diabetic foot infection and from a search in the current literature using the terms diabetic foot osteomyelitis and treatment/therapy/therapeutical in both PubMed and Medline, restricted to the last five years. Expert opinion: Surgical removal of the entire infected bone(s) has been considered in the past as the standard treatment but medical approach of these patients has now proven efficacy in selected situations. The current emergence of bacteria, especially among Gram negative rods, resistant to almost all the available antibiotics gradually augments the complexity of the management of these patients and is likely to decrease the place of the medical approach and to worsen the outcome of these infections in the next future.

Familial Transmission of emm12 Group A Streptococcus

Incidence and severity of invasive group A Streptococcus infections are of increasing concern in France and worldwide. The risk for secondary infection of close contacts is known but rarely described. We report a case of intrafamilial and life-threatening transmission of emm12 group A Streptococcus.

Two-Step Sequential Approach for Concomitant Skin and Soft Tissue Infection and Osteomyelitis Complicating the Diabetic Foot

Current guidelines (1,2) do not provide data on the treatment of patients presenting with concomitant soft tissue infection and osteomyelitis of the diabetic foot (DF-STI/DFO). We have developed a two-step sequential approach (TSA) consisting chronologically of 1 ) an empirical antibiotic therapy for diabetic foot soft tissue infection (DF-STI) secondarily adapted to the culture results of a tissue sample taken by curettage from the periphery of the ulcer (step 1), 2 ) an antibiotic-free period of at least 2 weeks, and 3 ) a bone biopsy obtained percutaneously or intraoperatively in case of, respectively, medical or surgical approach of diabetic foot osteomyelitis (DFO) (step 2) chosen according to Lipsky’s recommendations (3). In the present monocentric retrospective 2006–2015 study, 38 adult patients out of a total of 297 patients followed for DFO (12.8%) had concomitant DF-STI and DFO not requiring …