O. V. Bykhovskaya

Catalytic activity of new PdII-complexes of bidentate PIII—N—PIII-ligands in Suzuki—Miyaura reaction

A reaction of readily available bis(diphenylphosphino)amines with (PhCN)2PdCl2 was used to synthesize PdII-complexes [Pd{Ph2PN(R)PPh2}Cl2] (R = Pri, cyclo-C6H11, Ph), which exhibited a high activity in the cross-coupling of aryl bromides with phenylboronic acid.

Pishchimuka's Intramolecular Rearrangement. The General Method for the Synthesis of 2-Oxo-1,2λ5-thiaphoapholanes and Thiaphosphorinanes

A new method is developed for the synthesis of 2-substituted 2-oxo-1,2λ5-thiaphospholanes and thiaphosphorinanes (thiolphostones) on the basis of intramolecular Pishchimuka rearrangement of thiophosphonic and thiophosphinic esters with ω-chloroalkyl substituents at the phosphorus atom. Intermediate compound in the Pishchimuka rearrangement, 2-ethyl-2-ethoxy-1,2λ4-thiaphospholanium perchlorate, was isolated.

Alkylation of Hydrothiophosphoryl Compounds by Digalogenoalkanes Under Phase Transfer Caralysis Conditions

Abstract The course of reactions of hydrothiophosphotyl compounds with dihalogenoalkanee under PTC conditions depends both on the nature of halogen atom and the length of the alkylene chain.I reacts with CH2Br2 to yield Ph2P(S)CH3; with ICH2Cl Ph2P(S)CH2Cl is formed.

Synthesis of precursors to new tripodal phosphine oxide ligands

A number of precursors of new tripodal ligands was obtained by hydroxyethylation of the starting tris(2-hydroxyphenyl)phosphine oxide, followed by conversion of the resulting tris[2-(2-hydroxyethoxy) phenyl]phosphine oxide to trimesylate. The treatment of the latter with LiBr or NaN3 afforded the corresponding tribromo and triazido derivatives.

Synthesis and study of antitumor activity of 4 H -pyrano[3,2- c ]pyridines based on N -(2-azidoethyl)- and N -propargyl-3,5-bis(arylidene)piperidin-4-ones

The synthesis of 3,5-bis(arylidene)piperidin-4-ones containing the 2-azidoethyl (azides 1a–d) or propargyl (acetylenes 2a–c) group at the nitrogen atom of the 4-piperidinone ring was described. The in vitro MTT assay for cytotoxicity of these compounds toward the human tumor cell lines PC3, HCT116, and MCF7 and the human embryonic kidney cells HEK293 revealed that N-(2-azidoethyl)-3,5-bis(3-pyridylidene)piperidin-4-one (1c) and N-propargyl-3,5- bis(benzylidene)piperidin-4-one (2a) exhibit high activity (IC50 in the range of 1–5 μmol L–1). The reaction of compounds 1a–d and 2a–c with malononitrile affords the corresponding 4H-pyrano[3,2-c]pyridines 3a–d and 4a–c devoid of cytotoxicity. This is evidence of the importance of preserving the 1,5-diaryl-3-oxo-1,4-pentadiene moiety upon the modification of 3,5-bis(arylidene)piperidin-4-ones in drug design when searching for new antitumor agents based on these compounds.

Phase-transfer Tsuji—Trost allylation of CH-acids with the assistance of palladium complexes with bidentate P III —N—P III ligands

The Tsuji—Trost allylation of CH acids, in particular, those of the YCH2CO2Et type (Y = CO2Et, C(O)Me, CN), with allylic acetates in the K2CO3—DMF system in the presence of palladium catalysts with ligands RN(PPh2)2 (R = Ph, Pri, c-C6H11) is accomplished.

N -Allyl-substituted aminomethylene-1,1-bisphosphonates in 1,3-dipolar cycloaddition reaction with aromatic nitrile N -oxides

A reaction of N-allyl-substituted aminomethylene-1,1-bisphosphonates with aromatic nitrile N-oxides was used to obtain new aminomethylenebisphosphonates with one or two 3-arylisoxazoline rings at the nitrogen atom. NMR spectroscopy studies showed that the bisphosphonates with two isoxazoline fragments in the molecule exist in solution as a mixture of two diastereomers.

Complexes Of Thiophosphoryl Compounds with AgNO3

Abstract Under conditions of interphase catalysis complexiDg agenta L1, L2 and L3 have been synthesizedl. Using spectral and X-ray methods complex fomation of thises ligands with AgNO3 has been studied

Alkylation of Phosphorylmethylenetriphenylphosphoranes

Abstract Direction of alkylation of phosphoranes (I) depends on the nature of the substituent Y and the alkylating agent. Unsubstituted phosphorane reacts with CH3J yielding only the product of C-methylation (II), whereas the reaction with Me2SO4 proceeds at both ends of the OPC-triad, preferably yielding the O-alkylation product (IIIa, 80%).