Odilia M. Laceulle

The Structure of Psychopathology in Adolescence Replication of a General Psychopathology Factor in the TRAILS Study

This study aimed to replicate a study by Caspi and colleagues, which proposed that the structure of psychopathology is characterized by a general psychopathology factor, in addition to smaller internalizing and externalizing factors. Our study expanded the approach of the original by using continuous adolescent data and testing additional models, including both self- and parent-reported data, to bolster the robustness of the findings. Our findings indicate that the structure of psychopathology is best characterized by a model including a general factor, in addition to smaller internalizing and externalizing factors. These results emphasize the importance of this model for understanding the structure of psychopathology. Given the increasing emphasis on the importance of, and need for, replication, the overall evidence of a general factor seems rather robust.

Evidence for plasticity genotypes in a gene-gene- environment interaction: the TRAILS study

The purpose was to study how functional polymorphisms in the brain derived neurotrophic factor gene (BDNF val66met) and the serotonin transporter gene linked promotor region (5‐HTTLPR) interact with childhood adversities in predicting Effortful Control. Effortful Control refers to the ability to regulate behavior in a goal‐directed manner and is an interesting endophenotype for psychopathology because of its heritability and the association of low Effortful Control with both internalizing and externalizing problems. In a longitudinal population‐based study Effortful Control was assessed with the parent version of the Early Adolescent Temperament Questionnaire at age 11. Pregnancy and delivery adversities and childhood events were assessed in a parent interview at age 11. Long‐term difficulties until age 11 were assessed with a parent questionnaire at age 13.5. Blood or buccal cells were collected at age 16 for genotyping the rs6265 and rs25531 SNPs and the 5‐HTTLPR length polymorphism. The study included 1032 complete data sets. Effortful Control was significantly predicted by the interaction between BDNF val66met, 5‐HTTLPR and childhood events. The BDNF val66met val/val–5‐HTTLPR l′/l′ genotype was unaffected by childhood events, while having either at least one BDNF val66met met or 5‐HTTLPR s′ allele (l′/l′‐met‐carrier; l′/s′‐val/val; s′/s′‐val/val) made children sensitive to childhood events. Predictions of Effortful Control by pregnancy and delivery adversities and long‐term difficulties were largely independent of genotype. We concluded that the l′/l′‐met‐carrier, l′/s′‐val/val and the s′/s′‐val/val genotypes showed greatest plasticity while the l′/l′‐val/val genotype was unaffected by childhood events.

Stressful events and temperament change during early and middle adolescence : The TRAILS study

This project investigates how stressful events are related to deviations from normative temperament development during adolescence. Temperament traits were assessed at ages 11 and 16 years. Life–event data was captured using an interview (total n = 1197). Normative changes were found in all traits. A linear trend was found between the experience of stressful events and temperament development. Adolescents exposed to stressful events showed smaller decreases in fear and shyness, stronger decreases in effortful control and affiliation and smaller increases in high intensity pleasure. Exposure to stressful events was related to increases in frustration instead of decreases. Our results show that whereas normative development is mostly in the direction of maturation, adolescents who experienced stressful events showed less maturation of their temperament. Copyright

Genetic and Environmental Influences on the Longitudinal Structure of Neuroticism A Trait-State Approach

In this study, we sought to elucidate both stable and changing factors in the longitudinal structure of neuroticism using a behavioral genetic twin design. We tested whether this structure is best accounted for by a trait-state, a trait-only, or a state-only model. In line with classic views on personality, our results revealed substantial trait and state components. The contributions of genetic and environmental influences on the trait component were nearly equal, whereas environmental influences on the state component were much stronger than genetic influences. Although the overall findings were similar for older and younger twins, genetic influences on the trait component were stronger than environmental influences in younger twins, whereas the opposite was found for older twins. The current findings help to elucidate how the complex interplay between genetic and environmental factors contributes to both stability and change in neuroticism.

Why Not Everyone Gets Their Fair Share of Stress: Adolescent's Perceived Relationship Affection Mediates Associations Between Temperament and Subsequent Stressful Social Events

Temperamental differences are associated with subsequent stressful life events, a phenomenon that has in part been attributed to evocation. However, we remain ignorant about the mechanisms that mediate this process. In the current paper, we test whether differences in ‘perceived relationship affection’ accounted for part of the prospective association between temperament and stressful social event evocation in three social domains, viz. parents, peers and romantic partners. Data were derived from the Tracking Adolescents’ Individual Lives Survey, a large population cohort of Dutch adolescents (n = 1158). Parent–reported adolescent temperament and adolescents perceived affection were assessed at age 11 years. Stressful social events that occurred between age 11 and 16 years were captured using the event history calendar. Results indicate that adolescents evoke subsequent stressful social events based on their temperament, and that this association is partially mediated by perceived affection. Importantly, we found evidence for both generic and domain–specific associations, which indicates that social domains are related yet distinct. Taken together, the findings suggest that a search for mediating variables may be a promising way to increase our understanding of the mechanisms that underlie the social stress selection principle, and that perceived relationship affection is one of the candidates. Copyright

Social Information Processing and Cluster B Personality Pathology among Clinic-Referred Adolescents

Background: This study investigated relations between personality pathology and mentalizing capacities reflected in social information processing (SIP) of adolescents. Sampling and Methods: 96 adolescent outpatients completed a structured interview regarding SIP. Their clinicians completed a checklist based on DSM-IV, assessing severity of personality pathology. Results: Significant relations were found between the severity of personality pathology and SIP: the more severe the personality pathology, the higher the intensity of reported emotions, the more likely adolescents were to choose inadequate coping strategies and aggressive reactions in social situations, and the more positively they evaluated aggressive reactions. Severity of traits of antisocial (ASPD) and borderline personality disorder (BPD) had unique associations with distinctive SIP variables: ASPD being more related to inadequate coping strategies, less reflection on others motives and aggressive responses, and BPD being more related to avoidant or prosocial responses and in particular to memories of frustrating events. Conclusions: This study provides evidence for difficulties in SIP among adolescents with more severe personality pathology, suggesting that the steps in the SIP model can be used to operationalize mentalizing problems. The results seem to paint a picture of ASPD and BPD having a shared background, but their own specific problems concerning SIP.

Why Personality and Psychopathology Are Correlated: A Developmental Perspective Is a First Step but More Is Needed

Durbin and Hicks offered a provocative critique of current research linking personality traits with psychopathology. We had a generally positive response to their article despite reservations about classifying an entire field as stagnant. We describe our reservations and suggest that their developmental approach represents an important opportunity to create synergy across a number of sub-disciplines within psychology. We then underscore their point about the importance of process when attempting to understand the dynamic connections between personality traits and psychopathology. Copyright

Functional outcomes of child and adolescent mental disorders. Current disorder most important but psychiatric history matters as well

BACKGROUND Various sources indicate that mental disorders are the leading contributor to the burden of disease among youth. An important determinant of functioning is current mental health status. This study investigated whether psychiatric history has additional predictive power when predicting individual differences in functional outcomes. METHOD We used data from the Dutch TRAILS study in which 1778 youths were followed from pre-adolescence into young adulthood (retention 80%). Of those, 1584 youths were successfully interviewed, at age 19, using the World Health Organization Composite International Diagnostic Interview (CIDI 3.0) to assess current and past CIDI-DSM-IV mental disorders. Four outcome domains were assessed at the same time: economic (e.g. academic achievement, social benefits, financial difficulties), social (early motherhood, interpersonal conflicts, antisocial behavior), psychological (e.g. suicidality, subjective well-being, loneliness), and health behavior (e.g. smoking, problematic alcohol, cannabis use). RESULTS Out of the 19 outcomes, 14 were predicted by both current and past disorders, three only by past disorders (receiving social benefits, psychiatric hospitalization, adolescent motherhood), and two only by current disorder (absenteeism, obesity). Which type of disorders was most important depended on the outcome. Adjusted for current disorder, past internalizing disorders predicted in particular psychological outcomes while externalizing disorders predicted in particular health behavior outcomes. Economic and social outcomes were predicted by a history of co-morbidity of internalizing and externalizing disorder. The risk of problematic cannabis use and alcohol consumption dropped with a history of internalizing disorder. CONCLUSION To understand current functioning, it is necessary to examine both current and past psychiatric status.

Adversity-driven changes in hypothalamic-pituitary-adrenal axis functioning during adolescence. The trails study

The hypothalamic-pituitary-adrenal (HPA) axis has been proposed to be a key mechanism underlying the link between adversity and mental health, but longitudinal studies on adversity and HPA-axis functioning are scarce. Here, we studied adversity-driven changes in HPA-axis functioning during adolescence (N=141). HPA-axis functioning (basal cortisol, cortisol awakening response, anticipation of, reaction to and recovery after a stress task) was measured twice, at age 16 and 19. Adversity (i.e., social defeat and loss/illness) since age 16 was measured extensively with the Life Stress Interview at age 19. Adolescents who reported being exposed to social defeat showed increases in basal cortisol (ɳ2=0.029) and decreases in reaction to the stress task (ɳ2=0.030) from age 16-19, compared to their peers in the loss/illness and no stress group. The current study provides unique longitudinal data on the role of adversity in HPA-axis functioning. Evidence is provided that adversity can affect the bodys neuroendocrine response to stress, dependent on the nature of both the HPA-measures and adverse events under study.

Trajectories of change in symptom distress in a clinical group of late adolescents: The role of maladaptive personality traits and relations with parents: Change in symptom distress, maladaptive personality traits and relations with parents

Abstract In this study, it was analysed whether trajectories of change in symptom distress could be identified in a clinical group of late adolescents with personality pathology. Furthermore, it was examined whether maladaptive personality traits and relations with parents were predictive of following one of these trajectories. Three latent classes emerged from growth mixture modelling with a symptom inventory (n = 911): a Stable High, a Strong Decreasing and a Moderate Decreasing trajectory. Subsequently, by using multinomial logistic regression analyses in a subsample of late‐adolescents (n = 127), it was revealed that high levels of Negative Affectivity and Detachment were predictive of following the Strong Decreasing, and high levels of Detachment were predictive of following the Stable High trajectory. Support from or Negative Interactions with parents were not predictive of any of the trajectories. The current results contribute to the notion of individual trajectories of change in symptom distress and provide suggestions for screening patients on personality traits to gain insight in the course of this change.