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Dive into the research topics where Olga O. Krasnovskaya is active.

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Featured researches published by Olga O. Krasnovskaya.


Journal of Medicinal Chemistry | 2014

Mixed Valence Copper(I,II) Binuclear Complexes with Unexpected Structure: Synthesis, Biological Properties and Anticancer Activity

Alexander G. Majouga; Maria I. Zvereva; Maria P. Rubtsova; Dmitry A. Skvortsov; Andrei V. Mironov; Dulat M. Azhibek; Olga O. Krasnovskaya; Vasily M. Gerasimov; Anna V. Udina; Nikolay I. Vorozhtsov; E. K. Beloglazkina; Leonid Aleksandrovich Agron; Larisa V. Mikhina; Alla V. Tretyakova; N. V. Zyk; Nikolay S. Zefirov; Alexander V. Kabanov; Olga A. Dontsova

We have synthesized and characterized a panel of new binuclear mixed valence Cu(I,II) complexes containing substituted 2-alkylthio-5-arylmethylene-4H-imidazolin-4-ones with unusual structure. These complexes are shown to be cytotoxic for various cell lines. We have found that these compounds did not intercalate DNA, inhibited number of polymerases (telomerase predominantly), accumulated in the cell nucleus, and caused DNA degradation. Preliminary studies revealed that lead compound inhibited human breast adenocarcinoma growth in mice model.


Russian Chemical Bulletin | 2013

Structure determination of bis{(4Z)-1-(2-azidoethyl)-4-[(pyridin-2-yl)methylidene]-2-thiolatoimidazol-5(4H)-one}dicopper chloride from X-ray powder diffraction data

Andrei V. Mironov; Evgeny V. Antipov; E. K. Beloglazkina; Alexander G. Majouga; Olga O. Krasnovskaya; Vasily M. Gerasimov; N. V. Zyk

The new tridentate organic N2S-type ligand, (4Z)-1-(2-azidoethyl)-4-[(pyridin-2-yl)-methylidene]-2-thioxoimidazol-5(4H)-one (LH), was synthesized. The reaction of LH with copper(II) chloride in a CH2Cl2/MeOH mixture afforded the coordination compound of the composition L2Cu2Cl (3). The crystal structure of 3 was solved and refined from X-ray powder diffraction data. Complex 3 has a binuclear structure with a short interatomic Cu-Cu distance and one bridging chlorine atom, which is located almost symmetrically with respect to both metal atoms. The planar organic ligands are noncoplanar and are at an angle of 53.56(1)° to each other.


Archive | 2018

CCDC 1826602: Experimental Crystal Structure Determination

E. K. Beloglazkina; Olga O. Krasnovskaya; Dmitry A. Guk; V. A. Tafeenko; A. A. Moiseeva; N. V. Zyk; Alexander G. Majouga

Related Article: Elena K. Beloglazkina, Olga O. Krasnovskaya, Dmitry A. Guk, Viktor A. Tafeenko, Anna A. Moiseeva, Nikolai V. Zyk, Alexander G. Majouga|2018|Polyhedron|148|129|doi:10.1016/j.poly.2018.04.005


Archive | 2018

CCDC 1826604: Experimental Crystal Structure Determination

E. K. Beloglazkina; Olga O. Krasnovskaya; Dmitry A. Guk; V. A. Tafeenko; A. A. Moiseeva; N. V. Zyk; Alexander G. Majouga

Related Article: Elena K. Beloglazkina, Olga O. Krasnovskaya, Dmitry A. Guk, Viktor A. Tafeenko, Anna A. Moiseeva, Nikolai V. Zyk, Alexander G. Majouga|2018|Polyhedron|148|129|doi:10.1016/j.poly.2018.04.005


Archive | 2018

CCDC 1826644: Experimental Crystal Structure Determination

E. K. Beloglazkina; Olga O. Krasnovskaya; Dmitry A. Guk; V. A. Tafeenko; A. A. Moiseeva; N. V. Zyk; Alexander G. Majouga

Related Article: Elena K. Beloglazkina, Olga O. Krasnovskaya, Dmitry A. Guk, Viktor A. Tafeenko, Anna A. Moiseeva, Nikolai V. Zyk, Alexander G. Majouga|2018|Polyhedron|148|129|doi:10.1016/j.poly.2018.04.005


Archive | 2018

CCDC 1826603: Experimental Crystal Structure Determination

E. K. Beloglazkina; Olga O. Krasnovskaya; Dmitry A. Guk; V. A. Tafeenko; A. A. Moiseeva; N. V. Zyk; Alexander G. Majouga

Related Article: Elena K. Beloglazkina, Olga O. Krasnovskaya, Dmitry A. Guk, Viktor A. Tafeenko, Anna A. Moiseeva, Nikolai V. Zyk, Alexander G. Majouga|2018|Polyhedron|148|129|doi:10.1016/j.poly.2018.04.005


Journal of Inorganic Biochemistry | 2017

New copper(II) thiohydantoin complexes: Synthesis, characterization, and assessment of their interaction with bovine serum albumin and DNA

Ksenia Tishchenko; E. K. Beloglazkina; M. A. Proskurnin; Vladislav Malinnikov; Dmitriy Guk; Marina Muratova; Olga O. Krasnovskaya; Anna V. Udina; Dmitry A. Skvortsov; Radik R. Shafikov; Yan A. Ivanenkov; Vladimir Aladinskiy; Ivan D. Sorokin; O. I. Gromov; Alexander G. Majouga; N. V. Zyk


Polyhedron | 2018

Synthesis, characterization, and cytotoxicity of binuclear copper(II) complexes with tetradentate nitrogen-containing ligands bis-5-(2-pyridylmethylidene)-3,5-dihydro-4 H -imidazol-4-ones

E. K. Beloglazkina; Olga O. Krasnovskaya; Dmitry A. Guk; V. A. Tafeenko; A. A. Moiseeva; N. V. Zyk; Alexander G. Majouga


Успехи синтеза и комплексообразования = Advances in synthesis and complexing: сборник тезисов четвертой международной научной конференции: в 2 ч | 2017

Novel binuclear Cu(II) and Pt(II) - containing coordination compounds as potential antitumor therapeutic agents

M.P. Mazhuga; A.Y. Plodukhin; M.M. Makarov; Olga O. Krasnovskaya; N. V. Zyk; E. K. Beloglazkina; Alexander G. Majouga


Journal of Heterocyclic Chemistry | 2016

An Improved Protocol for Synthesis of 3‐Substituted 5‐Arylidene‐2‐thiohydantoins: Two‐step Procedure Alternative to Classical Methods

Olga Yu. Kuznetsova; R. L. Antipin; Anna V. Udina; Olga O. Krasnovskaya; E. K. Beloglazkina; V. I. Terenin; Victor Koteliansky; N. V. Zyk; Alexander G. Majouga

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N. V. Zyk

Moscow State University

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