Osamu Ohara
Nihon University
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Publication
Featured researches published by Osamu Ohara.
Journal of Biological Chemistry | 1998
Katsuhiko Sakamoto; Takahiro Nagase; Hiromi Fukui; Kazumasa Horikawa; Tetsuya Okada; Hitoshi Tanaka; Kazuo Sato; Yoshiaki Miyake; Osamu Ohara; Koichiro Kako; Norio Ishida
The period (per) gene, controlling circadian rhythms in Drosophila, is expressed throughout the body in a circadian manner. A homolog ofDrosophila per was isolated from rat and designated asrPer2. The rPER2 protein showed 39 and 95% amino acid identity with mPER1 and mPER2 (mouse homologs of per) proteins, respectively. A robust circadian fluctuation ofrPer2 mRNA expression was discovered not only in the suprachiasmatic nucleus (SCN) of the hypothalamus but also in other tissues including eye, brain, heart, lung, spleen, liver, and kidney. Furthermore, the peripheral circadian expression of rPer2mRNA was abolished in SCN-lesioned rats that showed behavioral arrhythmicity. These findings suggest that the multitissue circadian expression of rPer2 mRNA was governed by the mammalian brain clock SCN and also suggest that the rPer2 gene was involved in the circadian rhythm of locomotor behavior in mammals.
Archive | 2000
Takahiro Nagase; Reiko Kikuno; Manabu Nakayama; Makoto Hirosawa; Osamu Ohara
Archive | 2000
Noboru Yamaji; Kouichi Nishimura; Kunitake Abe; Osamu Ohara; Takahiro Nagase; Nobuo Nomura
Archive | 1999
Osamu Ohara; Takahiro Nagase; Nobuo Nomura; Kiyoshi Takayama; Hitoshi Toyoda; Makoto Yoshimoto
Archive | 2002
Osamu Ohara; Takahiro Nagase; Yutaka Katou; Tomohiro Takahashi; Kazuhumi Hkawa; Kamon Shirakawa
Archive | 2008
Yasushi Shigemori; Takehiko Shibata; Tsutomu Mikawa; Michio Oishi; Osamu Ohara
Archive | 2001
Osamu Ohara; Takahiro Nagase; Daisuke Nakajima
Archive | 2004
Shin-Ichi Funahashi; Shoji Miyata; Nobuo Nomura; Takahiro Nagase; Osamu Ohara
Archive | 2001
Osamu Ohara; Takahiro Nagase; Nobuo Nomura; Kazuhiro Yano; Kohji Murakami; Shin-Ichiro Yasuda; Koji Kanzaki
Archive | 2005
Osamu Ohara; Takahiro Nagase; Michio Ohishi; Hiroshi Yokota; Osamu Kamida