Oscar Barba
OSI Pharmaceuticals
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Publication
Featured researches published by Oscar Barba.
Bioorganic & Medicinal Chemistry Letters | 2012
Ustav Bali; Oscar Barba; Graham Dawson; William Gattrell; James Horswill; David A. Pan; Martin James Procter; Chrystelle Marie Rasamison; Colin Peter Sambrook Smith; Amanda Taylor-Warne; Philippe Wong-Kai-In
A series of potent carboxylic acid DGAT1 inhibitors with high permeability were developed from a virtual screening hit. Strategies were employed to reduce Pgp substrate recognition and increase passive permeability, resulting in the discovery of a series showing good inhibition of cellular triglyceride synthesis. The mutagenic potential of prospective metabolites was evaluated in the Ames assay, and one aniline was shown to be devoid of mutagenicity.
Archive | 2005
Saleh Ahmed; Oscar Barba; Jason Bloxham; Graham Dawson; William Gattrell; John Kitchin; Neil Anthony Pegg; Imaad Saba; Shazia Sadiq; Smith Colin Peter Sambrook; Don Smyth; Arno G. Steinig; Robin Wilkes; Kenneth Foreman; Qinghua Felix Weng; Kathryn M. Stolz; Paula A. R. Tavares; Bijoy Panicker; An-Hu Li; Hanqing Dong; Lifu Ma; Matthew Cox
Archive | 2010
Oscar Barba; Tom Banksia Dupree; Peter Timothy Fry; Matthew Colin Thor Fyfe; Revathy Perpetua Jeevaratnam; Thomas Martin Krulle; Karen Lesley Schofield; Donald Smyth; Thomas Staroske; Alan John William Stewart; David French Stonehouse; Simon Andrew Swain; David Matthew Withall
Archive | 2008
Oscar Barba; Graham Dawson; William Gattrell; Martin James Procter; Chrystelle Marie Rasamison; Colin Peter Sambrook-Smith; Philippe Wong-Kai-In
Archive | 2011
Oscar Barba; Lisa Sarah Bertram; Emma Louise Carswell; Susan Helen Davis; Peter Timothy Fry; Robert James Gleave; Revathy Perpetua Jeevaratnam; Craig Johnstone; John Keily; Martin James Procter; Karen Lesley Schofield; Alan John William Stewart; Simon Andrew Swain
Archive | 2011
Oscar Barba; James Charles Bell; Tom Banksia Dupree; Peter Timothy Fry; Lisa Sarah Bertram; Matthew Colin Thor Fyfe; William Gattrell; Revathy Perpetua Jeevaratnam; John Keily; Thomas Martin Krulle; Russell Walker Mcdonald; Trevor Morgan; Chrystelle Marie Rasamison; Karen Lesley Schofield; Alan John William Stewart; Simon Andrew Swain; David Matthew Withall
Archive | 2011
Oscar Barba; Tom Banksia Dupree; Karen Lesley Schofield; Alan John William Stewart; Simon Andrew Swain; David Matthew Withall
Tetrahedron Letters | 2007
Thomas Martin Krulle; Oscar Barba; Susan Helen Davis; Graham Dawson; Martin James Procter; Thomas Staroske; Gerard Hugh Thomas
Archive | 2005
Saleh Ahmed; Oscar Barba; Jason Bloxham; Graham Dawson; William Gattrell; John Kitchin; Neil Anthony Pegg; Imaad Saba; Shazia Sadiq; Colin Peter Sambrook Smith; Don Smyth; Amo G. Steinig; Robin Wilkes; Bijoy Panicker; Paula A. R. Tavares; Matthew Cox; An-Hu Li; Hanqing Dong; Lifu Ma; Kenneth Foreman; Qinghua Weng; Kathryn M. Stolz
Archive | 2010
Oscar Barba; Peter Timothy Fry; Matthew Colin Thor Fyfe; William Gattrell; Revathy Perpetua Jeevaratnam; Thomas Martin Krulle; Martin James Procter; Colin Peter Sambrook-Smith; Karen Lesley Schofield; Donald Smyth; Alan John William Stewart; David French Stonehouse; Simon Andrew Swain
