P. Laugier

Hyperplasies sébacées, kérato-acanthomes, épithéliomas du visage et cancer du colon

Numerous skin lesions: sebaceous hyperplasias, benign acanthoma, keratoacanthomas and squamous cell epitheliomas appeared on the face, especially on the nose, on the cheeks and around the lips of a 45

L’œdème aigu hémorragique du nourrisson (purpura en cocarde avec œdème)

Description of two cases of acute haemorrhagic oedema (purpura en cocarde with oedema) in infants with its clinical signs: oedema occurring distally, ecchymotic purpura en cocarde, associated generally with rhinopharyngeal manifestations. Histology: pericapillaritis with diapedesis and discrete inflammation is not pathognomonic.

Réticulo-histiocytome du dos de l’adulte

The clinical and histopathological pattern and the ultrastructural picture of a new case of the adult’s back reticulo-histiocytome, are described. Dysplasic and malignant aspect of the infiltrated cells, confirmed by nuclear anomalies, contrasting with the slowness in evolution of the disease and a good general status, justify the individuality of this disease in the complicated family of reticuloses.

Das experimentelle Keratoakanthom am Kaninchenohr (KA)

SummaryAfter topical application of the carcinogen DMBA on the rabbits ear, tumors will always appear. These are clinically characterised by their important hyperkeratosis. Some of these tumors develop rapidly and disappear completely as do KA.Others do not reach such an important size but do not regress. None of these tumors looked like a malignant tumor and did not show signs of invasiveness nor metastasis. However the histological findings reveal in some cases precancerous and malignant aspects. The number of tumors can be increased by lengthening the applicationtime of the carcinogen, by modifying the mode of application (repeated application and transport medium DMSO) and by irradiation.ZusammenfassungNach lokaler Applikation des Kanzerorgans DMBA auf das Kaninchenohr kommt es immer zur Tumorbildung, die klinisch durch eine stark ausgeprägte Hyperkeratose gekennzeichnet ist. Ein Teil dieser Tumoren nimmt rasch an Größe zu, neigt aber auch zu rascher, spontaner Rückbildung, so wie das für das KA bekannt ist. Andere der hervorgerufenen Tumoren erreichen nicht diese Größe, verschwinden aber nicht in allen Fällen. Kein Tumor hat wirklich malignes Verhalten gezeigt (Metastasen, schrankenloses Wachstum).Im Gegensatz zu dieser klinischen Beobachtung zeigte die histologische Untersuchung verschiedene präepitheliomatöse und maligne Bilder.Die Zahl der Tumoren kann durch die Dauer der Applikation des Kanzerogens erheblich erhöht werden, ebenso durch den Applikationsmodus (wiederholtes Auftragen, DMSO als Transportmilieu) und durch UV-Bestrahlung.

Membrane activity in histiocytic diseases of the skin.

Study of the histiocytes from a large variety of skin diseases demonstrates a close relationship between the cell processes peculiar to those cells and their degree of phagocytic activity. The membrane structures, as well as the dense bodies localized in the peripheral cytoplasm, suggest a type of endocytosis distinct from pinocytosis and phagocytosis.

Reactions sérologiques croisées envers les chlamydiae et certains virus au cours de la syphilis

Positive serological reactions for the Chlamidiae and for mumps virus were found among patients presenting a proven florid acquired syphilis; the fact that these patients had a positive syphilitic ser

Régression des tumeurs cutanées expérimentales de la souris sous l’effet de deux dérives de l’acide adenosine- 3’,5’-monophosphorique

N6,2’O-dibutyryl-cAMP and N6,2’O-8-thio-cAMP produced a favourable effect on skin tumours in mice induced by dimethyl-benzanthracene.

Recherche systématique de la blennorragie dans une consultation de planning familial

We report the result of an investigation carried out in the Gynecology Policlinic of Geneva. Systematic screening of 217 patients led to the detection of 2 cases of gonorrhea. Although of interest, it

Ultrastructure de la Kératinisation du kyste sebacé

SummaryIn this study four sebaceous cysts were examined electronmicroscopically. There was fatty degeneration of all the cells and no correlation was found to the existence or absence of keratohyalin in the peripheral cell layers. From this observation it follows, that the expression of different types of keratinisation, which one observes in such lesions appears to be independent from the original structure of the cells.ZusammenfassungIn dieser Studie wurden vier sog. Talgcysten elektronenmikroskopisch untersucht. Dabei zeigte sich eine fettige Degeneration sämtlicher epithelialer Zellen, unabhängig von dem Vorhandensein oder Fehlen von Keratohyalin in den oberen Zellagen. Aus dieser Beobachtung darf man folgern, daß die verschiedenen Keratinisationsformen des Wandepithels unabhängig von der ursprünglichen Struktur der Zellen auftreten können.