Padmanabhan. Sundararaman

Enantioselection in the birch reduction-alkylation of a chiral benzoic acid derivative

Abstract Preparation and diastereoselective Birch reduction-alkylation of benzoxazepenone 3 is described; conversion of 3 to ≈ enantiomerically pure 11 confirms the ∼98:2 diastereoselection in the alkylation step.

The enantioselective conversion of ortho-substituted benzoic acids to chiral cyclohexane derivatives

Abstract The diastereoselectivity of reductive methylation of 1a–1c to give 2a–2c and 11 to give 12 is 260:1 and >99:1, respectively.

Enantioselection via birch reduction-alkylation of a chiral anthranilic acid derivative. Synthesis of enantiomerically pure aminocyclohexanes

Abstract The first method for preparation of enantiomerically pure aminocyclohexanes by Birch reduction-alkylation of a chiral anthranilic acid derivative is described; stereochemistry of alkylation is demonstrated by X-ray structural studies with 2b .