Paola Venuti

An exploration of symmetry in early autism spectrum disorders: Analysis of lying

BACKGROUND Early identification of children with autism spectrum disorders (ASD) is recognized as a critical aspect of their medical management and treatment. Movement disorders are considered one of the first signs which probably precede social or linguistic abnormalities. OBJECTIVES to verify, through observational methods, the possibility of distinguishing infants with ASD from infants with typical development or with mental retardation by movement. METHODS The Eshkol-Wachman movement analysis system, which analyses static symmetry (SS) and dynamic symmetry (DS) during lying, was applied to retrospective home videos regarding the first 5 months of life of children with ASD (n=18), typical development (n=18), or developmental delay (n=12). RESULTS Significant differences between ASD and the two control groups were found for both SS (p<.001) and DS (p<.01). Within ASD two groups of infants could be differentiated on the basis of the higher (HLS) or the lower (LLS) levels of symmetry. Early onset ASD are more likely to belong to the LLS group. CONCLUSION We suggest that motor functioning may define specific subgroups of early ASD which are related to different pathways to the syndrome. LLS could be used as an early indicator of potential autism since the first months of life.

Analysis of unsupported gait in toddlers with autism

AIMS A number of studies have suggested the importance of motor development in autism. Motor development has been considered a possible bio-marker of autism since it does not depend on either social or linguistic development. In this study, using retrospective video analysis we investigated the first unsupported gait in toddlers with autism. METHODS Fifty-five toddlers, belonging to three groups were recruited: toddlers with autistic disorder (AD, n=20, age 14.2mo, sd 1.4mo) and as comparison groups: typically developing toddlers (TD, n=20, age 12.9mo, sd 1.1mo) and toddlers with non-autistic developmental delays of mixed aetiology (DD, n=15, age 13.1mo, sd 0.8mo). The Walking Observation Scale (WOS) and the Positional Pattern for Symmetry during Walking (PPSW) were used to gather data on the first unsupported gait. The WOS includes 11 items that analyze gait through three axes: foot movements; arm movements; general movements while the PPSW analyses static and dynamical symmetry during gait. RESULTS Our results have identified significant differences in gait patterns among the group of toddlers with AD as opposed to the control groups. Significant differences between AD and the two control groups were found for both WOS (p<.001) and PPSW (p<.001). CONCLUSION The specificity of motor disturbances we have identified in autism (postural asymmetry) is consistent with previous findings that implicated cerebellar involvement in the motor symptoms of autism.

Analysis of Toddlers' Gait after Six Months of Independent Walking to Identify Autism: A Preliminary Study

This research analyzed gait in toddlers and tested the hypothesis that movement can be used as an early indicator of Autistic Disorder. It was proposed that an early identification method could indicate differences in the gait of toddlers with autism as opposed to those with typical development or with mental retardation. Observational methods were applied to retrospective home videos of 42 children after 6 mo. of independent walking. In particular, the Walking Observation Scale was used, which includes 11 items that analyze gait through three axes of foot movements, arm movements, and global movements. Analysis showed different distributions for the three groups, i.e., the autistic group differed from the other two on scores for the Walking Observation Scale and each axis. After 6 mo. of independent walking, different patterns in gait among groups were evident. These results agree with recently published evidence which acknowledges the importance of movement as an early indicator for differential diagnosis of autism.

Sex differences in directional brain responses to infant hunger cries.

Infant cries are a critical survival mechanism that draw the attention of adult caregivers, who can then satisfy the basic needs of otherwise helpless infants. Here, we used functional neuroimaging to determine the effects of infant hunger cries on the brain activity of adults who were in a cognitively nondemanding mental state of awake rest. We found that the brains of men and women, independent of parental status (parent or nonparent), reacted differently to infant cries. Specifically, the dorsal medial prefrontal and posterior cingulate areas, known to be involved in mind wandering (the stream of thought typical of awake rest), remained active in men during exposure to infant cries, whereas in women, activity in these regions decreased. These results show sex-dependent modulation of brain responses to infant requests to be fed, and specifically, they indicate that women interrupt mind wandering when exposed to the sounds of infant hunger cries, whereas men carry on without interruption.

Functional and Dysfunctional Brain Circuits Underlying Emotional Processing of Music in Autism Spectrum Disorders

Despite intersubject variability, dramatic impairments of socio-communicative skills are core features of autistic spectrum disorder (ASD). A deficit in the ability to express and understand emotions has often been hypothesized to be an important correlate of such impairments. Little is known about individuals with ASDs ability to sense emotions conveyed by nonsocial stimuli such as music. Music has been found to be capable of evoking and conveying strong and consistent positive and negative emotions in healthy subjects. The ability to process perceptual and emotional aspects of music seems to be maintained in ASD. Individuals with ASD and neurotypical (NT) controls underwent a single functional magnetic resonance imaging (fMRI) session while processing happy and sad music excerpts. Overall, fMRI results indicated that while listening to both happy and sad music, individuals with ASD activated cortical and subcortical brain regions known to be involved in emotion processing and reward. A comparison of ASD participants with NT individuals demonstrated decreased brain activity in the premotor area and in the left anterior insula, especially in response to happy music excerpts. Our findings shed new light on the neurobiological correlates of preserved and altered emotional processing in ASD.

Infant Calming Responses during Maternal Carrying in Humans and Mice

BACKGROUND Mother-infant bonding is the earliest and most critical social relationship of mammalian infants. To promote this bond, infants have innate behaviors to seek maternal proximity and protest upon separation via communication with the mother vocally and through body movement. However, the physiological mechanisms regulating these infant behaviors remain largely undefined. RESULTS Here we show a novel set of infant cooperative responses during maternal carrying. Infants under 6 months of age carried by a walking mother immediately stopped voluntary movement and crying and exhibited a rapid heart rate decrease, compared with holding by a sitting mother. Furthermore, we identified strikingly similar responses in mouse pups as defined by immobility and diminished ultrasonic vocalizations and heart rate. Using pharmacologic and genetic interventions in mouse pups, we identified the upstream and downstream neural systems regulating the calming response. Somatosensory and proprioceptive input signaling are required for induction, and parasympathetic and cerebellar functions mediate cardiac and motor output, respectively. The loss of the calming response hindered maternal rescue of the pups, suggesting a functional significance for the identified calming response. CONCLUSIONS Our study has demonstrated for the first time that the infant calming response to maternal carrying is a coordinated set of central, motor, and cardiac regulations and is a conserved component of mammalian mother-infant interactions. Our findings provide evidence for and have the potential to impact current parenting theory and practice, since unsoothable crying is the major risk factor for child abuse.

Maternal personality and parenting cognitions in cross-cultural perspective

A total of 467 mothers of firstborn 20-month-old children from 7 countries (103 Argentine, 61 Belgian, 39 Israeli, 78 Italian, 57 Japanese, 69 Korean, and 60 US American) completed the Jackson Personality Inventory (JPI), measures of parenting cognitions (self-perceptions and knowledge), and a social desirability scale. Our first analysis showed that the Five-Factor structure of personality (Openness, Neuroticism, Extraversion, Agreeableness, and Conscientiousness) could be extracted from the JPI scales when cross-cultural data from mothers in the 7 countries were analyzed; it was also replicable and generalizable in mothers from so-called individualist and collectivist cultures. Our second analysis showed that the five personality factors relate differently to diverse parenting cognitions in those individualist versus collectivist cultures. Maternal personality has significance in studies of normative parenting, child development, and family process across cultural contexts.

Understanding early communication signals in autism: a study of the perception of infants' cry

BACKGROUND Previous studies have highlighted that episodes of crying of children with autistic disorder (AD) were perceived as inexplicable from their parents who could not identify causative factors. These results supported the view of AD as related to a problem of expressing and sharing emotions. Moreover, no evidence has been presented on which characteristics of a cry episode influence the adult perception. Aim of our research is to investigate how acoustical features of crying episodes modulate their perception of infants with ASD compared with infants with typical development (TD) and infants with developmental delay (DD). METHODS Two studies were employed. In study 1, we artificially modified structural parameters (fundamental frequency, duration of the pauses, waveform modulation) of a cry episode, and then 50 adults (parents and non-parents) were asked to judge the level of distress elicited. In study 2, acoustic analysis was applied to episodes of crying selected from retrospective home videos of 42 children with AD, TD and DD at 18 months. RESULTS The results showed that (1) differences in the fundamental frequency and in other structural parameters of the cry lead parents and non-parents to perceive an episode of crying as more aversive and (2) at 18 months of age, AD episodes of crying have higher fundamental frequency (f0). CONCLUSION Our findings offer support for the hypothesis that acoustic characteristics of episodes of crying of children with autism, especially higher fundamental frequencies, may account for mental states of uneasiness in the listener.

Fathers' Play with Their Down Syndrome Children.

BACKGROUND In children with Down Syndrome (DS), as in other groups of special needs children, development depends crucially on the degree to which parents provide appropriate stimulation and effective support. The majority of recent studies investigating interactions between parents and children with DS have been conducted on mothers. METHOD Through observation of child solitary play, child collaborative play with their father, and father play with their child, the current study focused on paternal contributions to child play in association with the effective quality of father-child interactions. A total of 19 children (M chronological age = 35.32 months, SD = 10.35; M mental age = 19.58, SD = 5.43) with DS and their fathers participated in the study. Two 10-min sessions, of child solitary play and collaborative play with their father, were videorecorded. A coding system for exploratory and symbolic play was applied to both sessions, and the Emotional Availability (EA) Scales were independently applied to the collaborative play session as a measure of the effective quality of the father-child interaction. RESULTS Children showed more symbolic play during collaborative sessions compared with solitary sessions. Bivariate correlations showed positive associations between father play and child exploratory and symbolic play. Cluster analysis identified dyads in low, medium and high EA groups, which differed in terms of each partners play. Specifically, both fathers and children of high EA dyads were more likely to show more symbolic play and less exploratory play than those with low EA dyads. CONCLUSIONS Our findings enrich the theoretical perspective that dyadic interactions based on emotional involvement may lead to enhanced cognitive functioning in children with DS.

Comparative Analysis of Crying in Children With Autism, Developmental Delays, and Typical Development

Crying behavior and mother-infant interactions during episodes of crying were coded using the Cry Observation Codes and then compared for 48 mother-infant dyads of children with autism, children with developmental delays, and typically developing children. At 1 year of age, children who would later be diagnosed with autism showed a different pattern of cry compared to the children in the comparison groups; specifically, their cries had less waveform modulation and more dysphonation. Maternal reactions to the crying of infants later diagnosed with autism were qualitatively different from the responses to cries of the other children of the same age (fewer tactile or vestibular stimulation and more verbal production). Implications of the study are described.