Paramasivan T. Perumal

InCl3 and In(OTf)3 catalyzed reactions: synthesis of 3-acetyl indoles, bis-indolylmethane and indolylquinoline derivatives

Indium trichloride and indium triflate were found to be effective catalysts for the acetylation of indoles to 3-acetyl indoles and is reported for the first time in good yield. Indium triflate is also found to be an efficient catalyst for the synthesis of bis-indolylmethane and indolylquinoline derivatives.

A Convenient Method of Synthesis of Bis-Indolylmethanes: Indium Trichloride Catalyzed Reactions of Indole with Aldehydes and Schiff's Bases

Abstract Anhydrous indium trichloride (InCl3) is found to catalyze the electrophilic substitution reaction of indole with aromatic aldehydes and Schiffs bases which resulted in an efficient synthesis of bis-indolylmethanes in good to excellent yield.

Convenient synthesis of pyrano[3,2-c]quinolines and indeno[2,1-c] quinolines by imino Diels-Alder reactions

Anhydrous indium trichloride (InCl3) is found to catalyze the imino Diels-Alder reaction of 3,4-dihydro-2H-pyran and indene with Schiffs bases to afford pyrano[3,2-c]quinolines and indeno[2,1-c] quinolines. Imino Diels-Alder reactions of N-benzylidene 1-naphthylamine with 3,4-dihydro-2H-pyran and indene results in efficient synthesis of phenanthridine derivatives.

Imino Diels-Alder reactions catalyzed by indium trichloride (InCl3). Facile synthesis of quinoline and phenanthridinone derivatives

Abstract Anhydrous indium trichloride (InCl 3 ) is found to catalyze the imino Diels-Alder reactions and results in facile synthesis of quinoline derivatives. A previously unreported series of phenanthridinones was obtained by the treatment of cyclohexenones with Schiff bases.

One-pot multicomponent synthesis and anti-microbial evaluation of 2'-(indol-3-yl)-2-oxospiro(indoline-3,4'-pyran) derivatives

A simple and efficient method for the one-pot three-component synthesis of new spirooxindoles in room temperature is described. The newly synthesized spirooxindoles were screened for anti-microbial activity and the results are good on comparison with of standard antibacterial compounds.

A novel application of the oxidizing properties of urea nitrate and peroxydisulfate-cobalt(II): aromatization of NAD(P)H model Hantzsch 1,4-dihydropyridines

4-Alkyl or aryl substituted derivatives of Hantzsch 1,4-dihydropyridine were readily oxidized by urea nitrate under microwave irradiation or refluxing conditions to the corresponding pyridine derivatives in quantitative yields. The oxidation reaction was also effected by peroxydisulfate in the presence of cobalt(II) in aqueous acetonitrile under refluxing conditions. When n-propyl, n-butyl and cinnamyl were the substituent groups in the 4-position, a mixture of 4-substituted and unsubstituted pyridines were formed. The catalysts used in the reaction are inexpensive and provide high yields in short reaction times.

Indium trichloride (InCl3)catalyzed imino Diels-Alder reactions: An efficient synthesis of cyclopentaquinolines, azabicyclooctanones and azabicyclononanones

Abstract Anhydrous indium trichloride (InCl 3 ) is found to catalyze the imino Diels-Alder reactions of Schiffs bases with cyclopentadiene, cyclohexen-2-one and cyclohepten-2-one which resulted in facile synthesis of cyclopentaquinolines, azabicyclooctanones and previously unreported series of azabicyclononanones.

ELECTROPHILIC SUBSTITUTION OF INDOLES CATALYZED BY TRIPHENYL PHOSPHONIUM PERCHLORATE: SYNTHESIS OF 3-ACETYL INDOLES AND BIS-INDOLYLMETHANE DERIVATIVES

ABSTRACT Triphenyl phosphonium perchlorate (TPP) is found to catalyze the acetylation of indoles with acetic anhydride to give 3-acetyl indoles. Similarly bis-indolylmethane derivatives were prepared by the electrophilic substitution reaction of indole with substituted benzaldehydes.

Triphenylphosphonium perchlorate as an efficient catalyst for mono- and bis-intramolecular imino Diels-Alder reactions: synthesis of tetrahydrochromanoquinolines

Triphenylphosphonium perchlorate (TPP) is found to be an efficient catalyst for the mono- and bis-intramolecular imino Diels–Alder (IMIDA) reaction of aldimines derived from aromatic amines and O-allyl derivatives of salicylaldehydes to afford the corresponding tetrahydrochromano[4,3-b]quinolines in excellent yields and short reaction times under mild conditions.

Practical synthesis, anticonvulsant, and antimicrobial activity of N-allyl and N-propargyl di(indolyl)indolin-2-ones.

An operation friendly protocol for the synthesis of novel di(indolyl)indolin-2-ones via Cu(OTf)(2) catalyzed bis-addition of N-allyl and N-propargyl indole with isatin was developed. This methodology allowed us to achieve the products in excellent yields without requiring purification technique like column chromatography. All the synthesized compounds were evaluated for their in vivo anticonvulsant activity against maximal electroshock test. Six compounds showed maximum activity compared to the standard drug phenytoin. The scope of the new molecules as antimicrobial agents were tested against two bacterial strains (Staphylococcus aureus and Escherichia coli) and one fungal strain (Candida albicans).