Prakasam Thirumurugan

One-pot multicomponent synthesis and anti-microbial evaluation of 2'-(indol-3-yl)-2-oxospiro(indoline-3,4'-pyran) derivatives

A simple and efficient method for the one-pot three-component synthesis of new spirooxindoles in room temperature is described. The newly synthesized spirooxindoles were screened for anti-microbial activity and the results are good on comparison with of standard antibacterial compounds.

InCl3 mediated one-pot multicomponent synthesis, anti-microbial, antioxidant and anticancer evaluation of 3-pyranyl indole derivatives

A simple and convenient method for the one-pot three-component synthesis of 3-pyranyl indoles has been accomplished by tandem Knoevenagel-Michael reaction of 3-cyanoacetyl indole, various aromatic aldehydes and malononitrile catalyzed by InCl(3) in ethanol under reflux conditions. The newly synthesized 3-pyranyl indoles were evaluated for anti-microbial, antioxidant, and anticancer activities. Some of the compounds showed good anticancer activity against MCF-7 breast cancer cell lines on comparison with of standard drug.

Synthesis and NMR spectral assignments of indol-3-yl pyridines through one-pot multi-component reaction

Asimple protocol for the efficient preparation of 6‐(ferrocene‐1‐yl)‐2‐(indol‐3‐yl)pyridine and 2‐(1H‐indol‐3‐yl)‐6‐(2‐thienyl)pyridine derivatives has been achieved through multi‐component reaction, and these compounds were thoroughly characterised by 2D NMR spectral techniques. Copyright

4-(2,4-Dichlorophenyl)-2-(1H-indol-3-yl)-6-(2-pyridyl)-1,4-dihydropyridine-4-carbonitrile

The title compound, C25H16Cl2N4, has intramolecular N—H⋯N and C—H⋯Cl hydrogen bonds. In the crystal structure, molecules are linked through N—H⋯N hydrogen bonds, forming a centrosymmetric R 2 2(16) dimer.

4-(4-Bromo­phen­yl)-6-(1H-indol-3-yl)-2,2′-bipyridine-5-carbonitrile

In the title compound, C25H15BrN4, the two pyridine rings lie in a common plane [r.m.s. deviation = 0.023 (2) Å], whereas the bromophenyl and indole rings are twisted away from this plane by 52.82 (12) and 28.02 (10)°, respectively. The crystal structure is stabilized by intermolecular N—H⋯N interactions.

4-(2,4-Dichloro­phen­yl)-6-(1H-indol-3-yl)-2,2′-bipyridine-5-carbonitrile

The title compound, C25H14Cl2N4, crystallizes with two independent molecules in the asymmetric unit. The two pyridine rings are almost coplanar, making dihedral angles of 3.2 (1) and 8.6 (1)° in the two independent molecules. The dichlorophenyl and indole rings are twisted away from the bipyridine ring by 64.32 (5) and 18.46 (4)°, respectively in the first molecule and by 51.0 (1) and 27.99 (5)°, respectively in the second molecule. The crystal packing is stabilized by C—H⋯N, C—H⋯Cl, N—H⋯N and C—H⋯π interactions.

4-(2,4-Dichlorophenyl)-2-(1H-indol-3-yl)-6-methoxypyridine-3,5-dicarbonitrile

In the title compound, C22H12Cl2N4O, the indole ring system and the benzene ring form dihedral angles of 21.18 (7)° and 68.43 (8)°, respectively, with the pyridine ring. The methoxy group is coplanar with the pyridine ring. In the crystal structure N—H⋯N intermolecular hydrogen bonds link the molecules into C(10) chains running along [011]. Intramolecular C—H⋯N hydrogen bonds are also observed.

4-(4-Chloro-phen-yl)-6-meth-oxy-2,2'-bipyridine-5-carbonitrile.

There are two independent molecules in the asymmetric unit of the title compound, C18H12ClN3O. The two pyridine rings are almost coplanar [dihedral angles between the rings: 2.87 (15) and 5.36 (16)°] while the chlorophenyl rings are twisted out of the plane of the adjacent bipyridine ring by 44.1 (1) and 43.8 (1)° in the two molecules. The crystal packing is stabilized by C—H⋯N and C—H⋯Cl interactions.

2-(1H-indol-3-ylcarbon­yl)acetonitrile

The title compound, C11H8N2O, crystallizes with two crystallographically independent molecules in the asymmetric unit which are approximately perpendicular to each other [79.97 (6)°]. The indole ring system is planar [r.m.s. deviation = 0.010 (1) Å]. The crystal structure is stabilized by intermolecular C—H⋯N and N—H⋯O interactions.