Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Patrick J. McLaren is active.

Publication


Featured researches published by Patrick J. McLaren.


Journal of Gastrointestinal Surgery | 2017

Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios can Predict Treatment Response to Neoadjuvant Therapy in Esophageal Cancer.

Patrick J. McLaren; Nathan W. Bronson; Kyle D. Hart; Gina M. Vaccaro; Ken Gatter; Charles R. Thomas; John G. Hunter; James P. Dolan

IntroductionWe hypothesized that serum neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios may predict pathologic complete response to neoadjuvant chemoradiotherapy in esophageal cancer patients. The ability to predict favorable treatment response to therapy may aid in determining optimal treatment regimens.Materials and MethodsA retrospective review of a prospective esophageal disease registry was conducted. Neutrophil-to-lymphocyte ratio was defined as the pre-chemoradiotherapy serum neutrophil count divided by lymphocyte count. Platelet-to-lymphocyte ratio was similarly defined. Logistic regression was applied to analyze these ratios and their effect on pathologic complete response. A Cox proportional-hazards model was used to analyze survival.ResultsSixty patients were included. Elevated neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio were both negative predictors of pathologic complete response (odds ratio: 0.62; 95% confidence interval: 0.37–0.89, P = 0.037 and odds ratio: 0.91; 95% confidence interval: 0.82–0.98, P = 0.028, respectively). Only platelet-to-lymphocyte ratio was predictive of decreased overall survival (hazard ratio: 1.05, 95% confidence interval: 0.94–1.16, P = 0.40).ConclusionElevated neutrophil and platelet-to-lymphocyte ratios were significant predictors of a poor treatment response to neoadjuvant therapy. Only elevated platelet-to-lymphocyte ratio was predictive of worse overall survival. Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios may offer a simple serum test to assess the likelihood of a pathologic complete response after neoadjuvant therapy in esophageal cancer.


JAMA Surgery | 2017

Paraesophageal hernia repair outcomes using minimally invasive approaches

Patrick J. McLaren; Kyle D. Hart; John G. Hunter; James P. Dolan

This study of inpatient admissions for paraesophageal hernia repair analyzes use of minimally invasive approaches and rates of intraoperative injury and in-hospital mortality.


Journal of Surgical Oncology | 2017

Laparoscopic ischemic conditioning of the stomach increases neovascularization of the gastric conduit in patients undergoing esophagectomy for cancer

Thai H. Pham; Shelby D. Melton; Patrick J. McLaren; Ali A. Mokdad; Sergio Huerta; David H. Wang; Kyle A. Perry; Hope L. Hardaker; James P. Dolan

Gastric ischemic preconditioning has been proposed to improve blood flow and reduce the incidence of anastomotic complications following esophagectomy with gastric pull‐up. This study aimed to evaluate the effect of prolonged ischemic preconditioning on the degree of neovascularization in the distal gastric conduit at the time of esophagectomy.


Archive | 2018

Hiatal Hernia and Reflux Following Bariatric Surgery

Dietric L. Hennings; Patrick J. McLaren; Samer G. Mattar; Dmitry Oleynikov

There has been a boom in popularity of weight loss surgery in recent decades, and many different bariatric procedures have been developed. Current methods have demonstrated excellent weight loss and metabolic outcomes with very low major complication rates. However, all bariatric operations are associated with some degree of postoperative complications. Hiatal hernia, GERD, bile reflux, gastrogastric fistula, and band malfunction are just some of the complications that can occur following weight loss surgery. We discuss the different complication profiles associated with laparoscopic gastric banding, vertical sleeve gastrectomy, and Roux-en-y gastric bypass. Primary treatments for postoperative GERD are medical with proton pump inhibitors. Surgical and endoscopic treatment options exist for refractory cases, including conversion to gastric bypass, magnetic sphincter augmentation, and endoscopic radio-frequency ablation. Surgical revision may also be needed in cases of hiatal hernia, gastrogastric fistula, and gastric band malfunction.


World Journal of Surgery | 2017

Surgical Treatment of High-Grade Dysplasia and Early Esophageal Cancer

Patrick J. McLaren; James P. Dolan


Journal of Clinical Oncology | 2017

Use of circulating tumor DNA levels to gauge necessity of surgery for patients undergoing trimodality therapy for esophageal cancer.

Nima Nabavizadeh; Patrick J. McLaren; Daira Melendez; Carol Halsey; Charles D. Lopez; Sharlene L. D'Souza; Brintha K. Enestvedt; James P. Dolan; Charles R. Thomas; Paul T. Spellman


American Journal of Surgery | 2017

Specific gene expression profiles are associated with a pathologic complete response to neoadjuvant therapy in esophageal adenocarcinoma

Patrick J. McLaren; Anthony P. Barnes; Willy Z. Terrell; Gina M. Vaccaro; Jack Wiedrick; John G. Hunter; James P. Dolan


Journal of Laparoendoscopic & Advanced Surgical Techniques | 2016

Esophagectomy as a Treatment Consideration for Early-Stage Esophageal Cancer and High-Grade Dysplasia

Patrick J. McLaren; James P. Dolan


Journal of Clinical Oncology | 2017

CUSUM analysis of mortality following esophagectomy to allow for identification and intervention of quality problems.

Patrick J. McLaren; Kyle D. Hart; James P. Dolan; John G. Hunter


Journal of Clinical Oncology | 2017

Association of specific gene expression profiles with a pathologic complete response to neoadjuvant therapy in esophageal adenocarcinoma.

Patrick J. McLaren; Anthony P. Barnes; Willy Z. Terrell; Gina M. Vaccaro; Jack Wiedrick; John G. Hunter; James P. Dolan

Collaboration


Dive into the Patrick J. McLaren's collaboration.

Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Ali A. Mokdad

University of Texas Southwestern Medical Center

View shared research outputs
Researchain Logo
Decentralizing Knowledge