Patrick Pichaud
L'Oréal
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Publication
Featured researches published by Patrick Pichaud.
Experimental Dermatology | 2002
Catherine Gerst; Maria Dalko; Patrick Pichaud; Jean-Baptiste Galey; B. Buan; Bruno Bernard
Abstract: Steroid 5α‐reductase catalyzes the reduction of testosterone (T) into the very potent androgen dihydrotestosterone (DHT). The different tissue expression patterns of the two isoforms of 5α‐reductase, namely type‐1 and type‐2 5α‐reductase (5α‐R1 and 5α‐R2, respectively), have prompted studies directed towards the synthesis of selective 5α‐R1 or 5α‐R2 inhibitors. In this present work, we have performed a structure/activity study on the inhibitory potential of indole carboxylic acids against hair follicle 5α‐reductase activity. We have demonstrated that this class of molecules were potent inhibitors of either 5α‐R1 or 5α‐R2 or both depending on (i) substituents in positions 4, 5 or 6 and (ii) the presence of a free carboxylic group. We have also found that only 5α‐R1 or 5α‐R1/R2 inhibitors were able to inhibit 5α‐reductase activity in plucked hairs from female volunteers or in freshly isolated female hair follicles, selective 5α‐R2 inhibitors being inactive.
Bioorganic & Medicinal Chemistry Letters | 2009
Alexandre Cavezza; Christophe Boulle; Amélie Guéguiniat; Patrick Pichaud; Simon Trouille; Louis Ricard; Maria Dalko-Csiba
Archive | 2005
Alexandre Cavezza; Patrick Pichaud; Simon Trouille
Free Radical Biology and Medicine | 1998
Jean-Baptiste Galey; Odile Destree; Jacqueline Dumats; Patrick Pichaud; Johann Marché; Sylvie Genard; Giovanni Bracciolli; Laurence Le Capitaine; Herve Plessix; Liliana Brambilla; Orazio Cantoni
Archive | 2005
Simon Trouille; Alexandre Cavezza; Patrick Pichaud
Archive | 1998
Bruno Bernard; Catherine Gerst; Jean-Baptiste Galey; Maria Dalko; Patrick Pichaud
Biochemical Pharmacology | 1996
Jean-Baptiste Galey; Jacqueline Dumats; Sylvie Genard; Odile Destree; Patrick Pichaud; Philippe Cctroux; Laurent Marrot; Irena Beck; Bona Fernandez; Gilles Barre; Michel Seite; Georges Hussler; Michel Hocquaux
Archive | 2001
Yann Mahe; Jean-Fran{tilde under }ois Michelet; Patrick Pichaud; Jean-Baptiste Galey
Archive | 2005
Alexandre Cavezza; Patrick Pichaud; Simon Trouille
Archive | 1997
Jean-Baptiste Galey; Patrick Pichaud