Paul F. Wiley

The crystal and molecular structure of 7-con-O-methylnogarol

A crystal structure analysis for 7-con-O-methylnogarol free base, a promising antitumor antibiotic of the nogalamycin family, has been carried out with low temperature X-ray diffraction data. The relative configuration of the anthracycline moiety is C7(S) and C9(S); the sugar moiety is an α-D-3,6-dideoxy-3-dimethylaminoglucose.