Paul J. Dobrowolski | Researchain

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Tetrahedron Letters | 1994

Taxol chemistry. 7-O-triflates as precursors to olefins and cyclopropanes

Roy A. Johnson; Eldon G. Nidy; Paul J. Dobrowolski; Ilse Gebhard; Samuel J. Qualls; Nancy Anne Wicnienski; Robert C. Kelly

Abstract 7-O-Triflates of baccatin III or of taxol analogs are convenient precursors in alternate syntheses of Δ 6,7 -taxols and 7β,8β-methano (cyclopropyl) taxols, two of the products initially obtained from reaction of taxols with methylDAST; hydrazine is an effective reagent for conversion of the 10-acetate group to the hydroxyl group.

International Journal of Peptide and Protein Research | 2009

Problems associated with use of the benzyloxymethyl protecting group for histidines Formaldehyde adducts formed during cleavage by hydrogen fluoride 1

Mark A. Mitchell; Thomas A. Runge; W. Rodney Mathews; Avneet K. Ichhpurani; Nancy K. Harn; Paul J. Dobrowolski; Frances M. Eckenrode

Organic Process Research & Development | 2001

Synthesis of 2,4-Di-1-pyrrolidinyl-9H-pyrimido[4,5-b]indoles, Including Antiasthma Clinical Candidate PNU-142731A

Gordon L. Bundy; Lee S. Banitt; Paul J. Dobrowolski; John R. Palmer; Theresa M. Schwartz; David C. Zimmermann; Michael F. Lipton; Michael A. Mauragis; Michael F. Veley; Robert Bruce Appell; and Robert C. Clouse; Edward D. Daugs

Journal of the American Chemical Society | 1996

12,13-ISOBACCATIN. III: TAXANE ENOL ESTERS (12,13-ISOTAXANES)

Robert C. Kelly; Nancy Anne Wicnienski; Ilse Gebhard; Samuel J. Qualls; Fusen Han; Paul J. Dobrowolski; Eldon G. Nidy; Roy A. Johnson

Archive | 2003

TRICYCLIC TETRAHYDROQUINOLINE ANTIBACTERIAL AGENTS

Michael R. Barbachyn; J. Craig Ruble; Arthur Glenn Romero; Lisa Marie Thomasco; Alexander R. Hurd; John R. Palmer; Peter L. Toogood; Dennis Joseph McNamara; Debra Ann Sherry; Paul J. Dobrowolski

Organic Process Research & Development | 1997

Production Scale Synthesis of the Non-Nucleoside Reverse Transcriptase Inhibitor Atevirdine Mesylate (U-87,201E)

William R. Perrault; K. Paul Shephard; Lori A. LaPean; Mark A. Krook; Paul J. Dobrowolski; Mark A. Lyster; Moses W. McMillan; Donald J. Knoechel; Gerald N. Evenson; William Watt, ,§ and; Bruce Allen Pearlman

Journal of Medicinal Chemistry | 1997

12,13-isotaxanes: synthesis of new potent analogs and X-ray crystallographic confirmation of structure.

Roy A. Johnson; Paul J. Dobrowolski; Eldon G. Nidy; Ilse Gebhard; Samuel J. Qualls; Nancy Anne Wicnienski; Robert C. Kelly; Thomas W. Pitts; Narima M. Lopes; Thomas F. DeKoning; Sally J. Mattern; Sheldon D. Weed; and J. Patrick McGovren; Constance G. Chidester

International Journal of Peptide and Protein Research | 2009

Hydrogen fluoride catalyzed migration of side chain protecting groups onto Fmoc during solid phase peptide synthesis

Stephen H. Grode; Diane S. Strother; Thomas A. Runge; Paul J. Dobrowolski

Archive | 1994

Piperazinylpyridinyl water clathrates

Bruce Allen Pearlman; Mark A. Krook; William R. Perrault; Paul J. Dobrowolski

Archive | 2003

Tricyclic tetrahydroquinolines with antibacterial effect

Michael R. Barbachyn; Paul J. Dobrowolski; Alexander R. Hurd; D J Mcnamara; John R. Palmer; Arthur Glenn Romero; James Craig Ruble; Debra Ann Sherry; Lisa Marie Thomasco; Peter L. Toogood; Gordon L. Bundy; Gary E. Martin; Donna Lee Romero

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