Paul Pedowitz

Dysgerminoma of the ovary

D YSGERMINOMA is an epithelial neoplasm which, though morphologically malignant, has been considered, heretofore, relatively benign and less malignant clinically than the granulosa-cell carcinomas. It is identical in structure to the seminoma occurring in the testis. Several designations for this tumor have been used in the past, such as smalland large-cell carcinomas, embryonal-cell carcinoma, seminoma, and others. Today the name rlysgerminoma, first introduced by Robert Meyer,’ is commonly used.

Diabetes mellitus and pregnancy (1932–1957): An analysis of the factors responsible for the improved fetal salvage during the current decade

1. 1. A total of 360 viable pregnancies in diabetic patients from 1932 to the present are reviewed. 2. 2. The viable fetal loss in the earlier series (1932 to 1949) was 22 per cent and in the current series (1950 to date) was 8.7 per cent. 3. 3. The method of management responsible for this improvement is presented. 4. 4. The patient with an abnormal glucose tolerance curve during pregnancy should be treated as a diabetic. 5. 5. Further education and cooperation of patients are necessary to improve fetal salvage in the diabetic. 6. 6. In the uncomplicated case, termination of pregnancy more than 28 days prior to the estimated date of labor will result in an increased fetal mortality.

Late postpartum hemorrhage

Abstract As defined in this paper, late postpartum hemorrhage indicates prolonged or excessive uterine bleeding beginning after the first day following delivery. The attempts of other authors (Roberton and Kleinwachter 1 ) to extend the interval to reach from the first to the twenty-eighth day postpartum, and to subgroup an early and later type, offer no advantages. The frequency of l.p.p.h. † †Late postpartum hemorrhage, elsewhere designated by l.p.p.h. is difficult to ascertain because of the paucity of reports. Williams 13 and DeLee 14 make only brief mention of the subject, while Davis and Schuman omit any reference to its occurrence. In American literature only one report by N. H. Williams appeared on this subject since 1939. 12 Chiare and Roberton 1 record an incidence of 1:250 to 1:300 for the late group of postpartum hemorrhage from all causes. This paper, however, excludes cases of l.p.p.h. from ruptured varicies or atheromatous vessels, from coincidental tumors (fibroids or carcinoma), from lacerations (cervical, perineal, and vulval), and from uterine inversion. It deals with late postpartum bleeding due to: (1) Retained placental fragments. Focal placental accreta is not recorded in this group, but there is one case of a retained succenturiate lobe. The remaining cases are fragments derived from normal placentas. (2) Uterine abnormalities in involution of the placental site. (3) Uterine abnormalities in retention and separation of the decidua vera.

Criteria for the diagnosis of malignancy in theca-cell tumors

Abstract A malignant theca-cell tumor has been reported. The patient is living and well eight years after removal of only a portion of the neoplasm. Postoperative radiation therapy resulted in the disappearance of clinical evidence of the growth. Approximately 3 per cent of all theca-cell tumors are malignant. Criteria for the histologic diagnosis of malignancy in theca-cell tumors have been outlined and discussed.