Paul Starr

A Graphic Representation of Thyroid Response to Stimulation by Thyrotropic Hormone

Conclusion We have described a micrometric method of representing the thyrotropic effect on the thyroid gland of test animals. Since each increased dosage of the hormone caused a characteristic curve, this procedure affords a quantitative method of determining the effects of the thyrotropic hornioiie on the thyroid of the guinea pig.

THERAPEUTIC STUDIES IN HYPERTHYROIDISM

Excerpt For several years attempts to suppress hyperthyroidism by various medicaments have been carried out in our clinic. The rationale of this project is furnished by the occurrence of spontaneou...

OBSERVATIONS OF REMISSIONS IN HYPERTHYROIDISM INDUCED BY PREGNANCY URINE EXTRACT

Excerpt Two years ago the administration of pregnancy urine extract (Antuitrin S)†to patients with hyperthyroidism was begun in this Clinic.‡A summary of metabolic results has been reported.1In som...

THE EFFECT OF LEVO-THYROXINE, DEXTRO-THYROXINE AND LEVO-TRI-IODO-THYRONINE ON THE ELECTROCARDIOGRAM IN MYXEDEMA: PRELIMINARY REPORT

Excerpt This preliminary report concerns the beginning of a study of the action of thyroxine on the heart. Its effects are so powerful and beneficial in the case of the heart of the hypothyroid pat...

Rapid Response of Guinea Pig Thyroid to a Single Injection of Thyrotropic Hormone

Summary and Conclusions A single, subcutaneous injection of thyrotropic hormone will result in a significant increase in mean acinar cell height within 8 to 16 hours, which is comparable to that heretofore reported in 72 hours following a series of daily injections. This measured response persists at least 48 hours following injection.

Clinical Studies with the Thyreotropic Pituitary Hormone

Summary A review of the published reports of the clinical application of the thyreotropic pituitary hormone is given. Our experience with 24 patients is outlined. In normal patients there is great individual variation in reactiveness to the material, as indicated by the basal metabolic rate. This is also true in castrate women. Some patients with low metabolic rates respond, whereas others do not. Patients with goiters respond with similar individual variation. In one, a diminution of the goiter was observed. Acute temporary exacerbation of hyperthyroidism has been produced in 2 patients; this has been prevented by iodine in others; in one patient with hyperthyroidism refractoriness to the medication seemed present before treatment, and treatment was followed by a fall in metabolic rate.

Effect of Castration on Thyroid in Female Guinea Pigs

A study of the literature on the effect of castration on the thyroid gland has shown many contradictory results. Earlier work seems to indicate a reduced thyroid activity in castrate animals. A decreased metabolic rate after castration has been reported by Loewy and Richter 1 and by Savage, Sherwood and Hall. 2 Histological studies by Korenchevsky, 3 Constantini 4 and Chouke 5 show a decreased activity of the gland and a decrease in the number of mitotic figures. A decrease in the weight of the thyroid and an atrophy of the gland have been reported by Anderson and Kennedy 6 and Bokelman. 7 Others have reported no marked change in the structure or weight of the gland, namely Leonard, Myer and Hisaw 8 and Freudenberger and Billeter. 9 More recent work by Bialet-Laprida 10 and Korenchevsky and Dennison 11 report a slight hypertrophy of the thyroid. Bates, Riddle and Lahr 12 in a quantitative assay of the occurrence of thyreotropic hormone in 7 types of cattle classified as to age, sex and stage of reproductive cycle, found a decreased amount of hormone in the pituitary gland of steers (adult, male castrates). Contradictory results have been reported independently by Loeser and Aron. Loeser, 13 who has studied the thyreotropic hormone extensively, claims that 18 days after castration the thyroid gland of female guinea pigs is markedly stimulated. Other work by Loeser 14 indicates that the pituitary gland of a castrated animal when implanted into a normal animal will cause an increased activity of the thyroid gland, greater than the stimulation resulting from the implantation of the pituitary of a normal non-castrated animal. Aron 15 claims that castration increases the titrable amount of thyreotropic hormone in the blood. I. The histology of the thyroid gland of female guinea pigs, 18 to 23 days after castration was determined by a study on 37 animals in 4 groups, with weights varying from 120 to 1030 gm.