Peter Charles Astles
Aventis Pharma
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Publication
Featured researches published by Peter Charles Astles.
Bioorganic & Medicinal Chemistry | 2001
Peter Charles Astles; Neil Victor Harris; Andrew David Morley
Design and synthesis of a library as potential VLA-4 antagonists has been accomplished, based around a proposed pharmacophoric model. Compounds possessing submicromolar potency were identified and structure-activity relationships were seen across the library. Further derivatisation produced compounds with IC(50)s <10 nmol for inhibiting the VLA-4 mediated binding of fibronectin to RAMOS cells, providing an ideal starting point for a lead optimisation Programme.
Archive | 1997
Paul Joseph Cox; Shelley Bower; David J. Aldous; Peter Charles Astles; Daniel G. Mcgarry; Christopher Hulme; John Robinson Regan; Fu-chih Huang; Stevan Wakefield Djuric; Kevin Joseph Moriarty; Rose Mappilakunnel Mathew; Gregory Bernard Poli
Archive | 1997
Paul Joseph Cox; Shelley Bower; David J. Aldous; Peter Charles Astles; Daniel G. Mcgarry; Christopher Hulme; John Robinson Regan; Fu-chih Huang; Stevan Wakefield Djuric; Kevin Joseph Moriarty; Rose Mappilakunnel Mathew; Gregory Bernard Poli
Archive | 2001
Peter Charles Astles; Paul Robert Eastwood; Olivier Houille; Julian Levell; Heinz W. Pauls; Mark Czekaj; Guyan Liang; Yong Gong; James Pribish; Kent Neuenschwander
Archive | 2001
Heinz W. Pauls; Yong Gong; Julian Levell; Peter Charles Astles; Paul Robert Eastwood
Archive | 1999
Peter Charles Astles; Neil Victor Harris; Andrew David Morley
Bioorganic & Medicinal Chemistry | 2005
Julian Levell; Peter Charles Astles; Paul Robert Eastwood; Jennifer Cairns; Olivier Houille; Suzanne Aldous; Gregory H. Merriman; Brian Whiteley; James Pribish; Mark Czekaj; Guyan Liang; Sébastien Maignan; Jean-Pierre Guilloteau; Alain Dupuy; Jane Davidson; Trevor K.P. Harrison; Andrew David Morley; Simon Watson; Garry Fenton; Clive McCarthy; Joseph Romano; Rose Mappilakunnel Mathew; Darren Engers; Michael Gardyan; Keith Sides; Jennifer Kwong; Joseph Tsay; Sam Rebello; Liduo Shen; Jie Wang
Archive | 2000
Peter Charles Astles; Neil Victor Harris; Andrew David Morley
Archive | 2001
Peter Charles Astles; Paul Robert Eastwood; Olivier Houille; Julian Levell; Heinz W. Pauls; Mark Czekaj; Guyan Liang; Yong Gong; James Pribish; Kent Neuenschwander
Archive | 2001
Heinz W. Pauls; Paul Robert Eastwood; Peter Charles Astles; Yong Gong; Julian Levell
