Peter R. Manninen | Researchain

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Featured researches published by Peter R. Manninen.

Bioorganic & Medicinal Chemistry Letters | 1998

Synthesis and antibacterial activity of [6,5,5] and [6,6,5] tricyclic fused oxazolidinones

D.Mark Gleave; Steven J. Brickner; Peter R. Manninen; Debra A. Allwine; Kristine D. Lovasz; Douglas C. Rohrer; John A. Tucker; Gary E. Zurenko; Charles W. Ford

A series of conformationally restricted, [6,5,5] and [6,6,5] tricyclic fused oxazolidinones were synthesized and tested for antibacterial activity. Several compounds in the trans-[6,5,5] series demonstrated potent in vitro and in vivo activity. This work provides valuable information regarding the preferred conformational orientation of the oxazolidinones at the binding site.

Journal of Medicinal Chemistry | 2008

Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections.

Steven J. Brickner; Michael R. Barbachyn; Douglas K. Hutchinson; Peter R. Manninen

Bioorganic & Medicinal Chemistry Letters | 2007

7 -oxo -4,7 -dihydrothieno [3,2 -b]pyridine -6 -carboxamides : Synthesis and biological activity of a new class of highly potent inhibitors of human cytomegalovirus DNA polymerase

Scott D. Larsen; Zhijun Zhang; Brian A. DiPaolo; Peter R. Manninen; Douglas C. Rohrer; Michael J. Hageman; Todd A. Hopkins; Mary L. Knechtel; Nancee L. Oien; Bob D. Rush; Francis J. Schwende; Kevin Stefanski; Janet L. Wieber; Karen F. Wilkinson; Kathyrn M. Zamora; Michael W. Wathen; Roger J. Brideau

Journal of Medicinal Chemistry | 2015

Discovery of 6-(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia

Michael J. Genin; Ana B. Bueno; Javier Agejas Francisco; Peter R. Manninen; Wayne P. Bocchinfuso; Chahrzad Montrose-Rafizadeh; Ellen A. Cannady; Timothy M. Jones; John R. Stille; Eyas Raddad; Charles Reidy; Amy L. Cox; M. Dodson Michael; Laura F. Michael

Organic Syntheses | 2005

Preparation of N‐Aryl‐5R‐Hydroxymethyl‐2‐Oxazolidinones from N‐Aryl Carbamates: N‐Phenyl‐(5R)‐Hydroxymethyl‐ 2‐Oxazolidinone

Peter R. Manninen; Steven J. Brickner

Archive | 2007

Agonistes de récepteur de farnesoide x

Michael Gregory Bell; Robert Anthony Doti; Michael J. Genin; Peter Ambrose Lander; Tianwei Ma; Peter R. Manninen; Jason Matthew Ochoada; Fucheng Qu; Lindsay Scott Stelzer; Ryan Edward Stites; Alan M. Warshawsky

Archive | 2007

Composés et procédés pour moduler fxr

Francisco Jav Agejas-Chicharro; Michael Gregory Bell; Melendo Ana Belen Bueno; Robert Anthony Doti; Michael J. Genin; Peter Ambrose Lander; Tianwei Ma; Peter R. Manninen; Jason Matthew Ochoada; Quanrong Shen; Lindsay Scott Stelzer; Ryan Edward Stites; Alan M. Warshawsky

Archive | 2007

Compounds and methods for modulating receptors FX

Michael Gregory Bell; Michael J. Genin; Peter Ambrose Lander; Lindsay Scott Stelzer; Robert Anthony Doti; Francisco Javier Agejas-Chicharro; Melendo Ana Belen Bueno; Peter R. Manninen; Jason Matthew Ochoada; Quanrong Shen; Alan M. Warshawsky; Tianwei Ma; Ryan Edward Stites

Archive | 1997