Peter Ullsperger

Experimental evaluation of eye-blink parameters as a drowsiness measure

Drowsiness and increased tendency to fall asleep during daytime is still a generally underestimated problem. An increased tendency to fall asleep limits the efficiency at work and substantially increases the risk of accidents. Reduced alertness is difficult to assess, particularly under real life settings. Most of the available measuring procedures are laboratory-oriented and their applicability under field conditions is limited; their validity and sensitivity are often a matter of controversy. The spontaneous eye blink is considered to be a suitable ocular indicator for fatigue diagnostics. To evaluate eye blink parameters as a drowsiness indicator, a contact-free method for the measurement of spontaneous eye blinks was developed. An infrared sensor clipped to an eyeglass frame records eyelid movements continuously. In a series of sessions with 60 healthy adult participants, the validity of spontaneous blink parameters was investigated. The subjective state was determined by means of questionnaires immediately before the recording of eye blinks. The results show that several parameters of the spontaneous eye blink can be used as indicators in fatigue diagnostics. The parameters blink duration and reopening time in particular change reliably with increasing drowsiness. Furthermore, the proportion of long closure duration blinks proves to be an informative parameter. The results demonstrate that the measurement of eye blink parameters provides reliable information about drowsiness/sleepiness, which may also be applied to the continuous monitoring of the tendency to fall asleep.

Mobile phones modulate response patterns of human brain activity

MOBILE phones emit a pulsed high-frequency electromagnetic field (PEMF) which may penetrate the scalp and the skull. Increasingly, there is an interest in the interaction of this pulsed microwave radiation with the human brain. Our investigations show that these electromagnetic fields alter distinct aspects of the brains electrical response to acoustic stimuli. More precisely, our results demonstrate that aspects of the induced but not the evoked brain activity during PEMF exposure can be different from those not influenced by PEMF radiation. This effect appears in higher frequency bands when subjects process task-relevant target stimuli but was not present for irrelevant standard stimuli. As the induced brain activity in higher frequency bands has been proposed to be a correlate of coherent high-frequency neuronal activity, PEMF exposure may provide means to systematically alter the pattern fluctuations in neural mass activity.

The P300 to novel and target events: A spatio-temporal dipole model analysis

It has been reported that frontal lobe structures are critical for the generation of P300 activity in the human event-related potential (ERP) evoked by novel events. In this study spatial–temporal dipole model analyses were employed to obtain further evidence on the temporal dynamics and the approximate location of neuronal activity involved in P300 generation for target and novel events. A triple dipole configuration was found to describe the scalp recorded P300 activity for novel and target events with less than 2.5% residual variance. For the novel, but not the target dipole configuration a frontally oriented dipole was obtained whose temporal activity function suggests that the brain areas involved in the processing of novel events are engaged about 70 ms earlier than those relevant for target processing.

Microwaves emitted by cellular telephones affect human slow brain potentials

Abstract The influence of electromagnetic fields (EMF) emitted by cellular telephones on preparatory slow brain potentials (SP) was studied in two experiments, about 6 months apart. In the first experiment, a significant decrease of SP was found during exposure to EMF in a complex visual monitoring task (VMT). This effect was replicated in the second experiment. In addition to the VMT, EMF effects on SP were analysed in two further, less demanding tasks: in a simple finger movement task to elicit a Bereitschaftspotential (BP) and in a two-stimulus task to elicit a contingent negative variation (CNV). In comparison to the VMT, no significant main EMF effects were found in BP and CNV tasks. The results accounted for a selective EMF effect on particular aspects of human information processing, but did not indicate any influence on human performance, well-being and health.

P3 varies with stimulus categorization rather than probability

We examined the relationship between P3 amplitude elicited by different auditory task stimuli and response-defined categorization requirements. Two experiments were conducted which examined the effects of the categorization of tone pitches (experiment 1) and spoken digits (experiment 2) on P3 amplitude. The categorization requirements were the same in both experiments. Two patterns of results were found in experiment 1: first, when subjects had to categorize an end term within the stimulus scale the largest P3 amplitudes were elicited by this stimulus. Secondly, when all tone pitches had to be categorized separately or when the categorization of the middle tone pitch was required, P3 amplitudes were smallest for the middle tone pitch and increased in amplitude at both ends of the stimulus scale. Different patterns of results were found in experiment 2. When subjects had to categorize 1 out of 5 spoken digits the largest P3 amplitudes were elicited by this digit no matter which position it had on the stimulus scale. In addition, only negligible P3s were found in the condition in which each of the digits had to be categorized separately. It is argued (i) that spoken words yield a higher degree of distinctiveness than tone pitches and (ii) that P3 amplitude is related to the probability of response-defined task categories only to the extent that stimuli can easily be assigned to categories.

Auditory probe sensitivity to mental workload changes – an event-related potential study

The goal of this study was to explore the utility of parameters of ERPs for assessment of mental workload during performance of complex tasks. In addition to a baseline auditory oddball task, 15 healthy adult volunteers performed gauge monitoring (Gauge) and mental arithmetic (Math) separately and together. Throughout the task performance three types of auditory stimuli were presented as probes, i.e. 80% 1000 Hz tones, 10% 2000 Hz tones and 10% novel sounds. The ERP components N1 and P3 were analysed, which are assumed to reflect perceptive and central processing resources. The results interpreted in the framework of capacity theory indicate high demand on processing resources already during separate performance of both tasks Gauge or Math. During simultaneous performance the workload on average exceeded the limits of processing capacity: the performance data impaired significantly. The ERP measures N1 and P3 were confirmed in their sensitivity and diagnosticity. By using novel sounds as probes with involuntary attention-capturing properties, one might overcome a problem of the irrelevant probe technique, i.e. whether the operator spends his spare capacity for processing of the irrelevant probes.

Event-related potential correlates of individual differences in working memory capacity.

The capacity of working memory has been suggested to differ among people and these differences affect performance in a wide variety of cognitive tasks. This study explored electrophysiological correlates of individual differences in working memory capacity by means of event-related potentials. Thirty-four healthy students performed two- and five-choice reaction time tasks. In the two-choice reaction time (2CRT) task, two digits (3 and 7) were presented visually with probabilities of .20 and .80. In the five-choice reaction time (5CRT) task, five digits (3, 4, 5, 6, and 7) were presented equiprobably in a random order. Participants were required to press a button corresponding to each digit with a different finger. Working memory capacity of each participant was assessed by the reading span test originated by M. Daneman and P.A. Carpenter (1980). Participants with high reading span produced larger P300s than did persons with low reading span in the 5CRT task, but the difference was not significant in the 2CRT task. It had been suggested that individual differences in working memory capacity would affect initial stages of information processing as early as 300 ms after stimulus onset.

EEG power changes during a multiple level memory retention task.

EEG changes related to the amount of information held in memory during a 4-s retention period were studied. The predictability of the amount of information held in memory was varied. In the weighted condition, 60% of the trials contained only one item and the remaining 40% of the trials were evenly distributed between trials containing 3, 5, 7, or 8 items. In the random condition, the levels were equally represented and randomly presented. In the blocked condition the levels were equally represented but presented in five blocks containing only items from one of the levels. Initial widespread decreases in alpha band power were followed by increased activity in all three conditions. The more difficult of the five levels produced decreased alpha activity in more localized posterior left hemisphere sites. This suggests two alpha mechanisms, one associated with task engagement and the other related to the cognitive demands regardless of the presentation context. Theta band power increased over frontal scalp, and to a lesser extent over left parietal and temporal areas and bilateral occipital sites, during only the weighted condition. These changes were uniform over the entire retention period. Beta 2 activity was also influenced by the task difficulty and the time course of the retention period in the two conditions. Beta 2 activity resembled both alpha and theta in that in levels 1, 2 and 3 it acted like alpha with increasing power over time at numerous widespread sites while the higher difficulty levels showed higher power at the beginning of the retention period and then decreased.

ERP components elicited in response to warning stimuli: the influence of task difficulty.

A series of experiments were conducted to systematically evaluate the relative contributions of task difficulty and stimulus probability to P300 amplitudes. Scalp event-related potentials (ERPs) were recorded and the topographic distributions were evaluated during a multi-level cognitive task with an antecedent warning. In three separate studies, task difficulty (five levels), probability or expectedness (10-60%), and randomness (random or blocked presentation) were manipulated. Response accuracy, subjective ratings, and reference-free averages of the P300 components elicited by the warning stimuli were evaluated. Statistical analysis indicated that significantly larger P300s were associated with the more difficult task warnings except when memory tasks were presented in a blocked design, suggesting that neither task difficulty nor probability alone can account for variations in the P300 in a multi-level task scenario. Results are discussed with regard to adaptation-level theory.

Adverse psychosocial working conditions and subjective health in freelance media workers

Abstract In recent years there has been a steady growth of non-standard work contracts in advanced societies. These contracts are characterized by increased flexibility of work arrangements and increased job instability, which holds particularly true for the media industry. This pilot study analyses associations of work stress with subjective health in a group of German freelancers (N = 290) working in the media industry. The measurement of work stress is based on the effort-reward imbalance model. Results of logistic regression analyses indicate significant effects of high effort in combination with low reward (money, esteem, promotion prospects, job security) on subjective health in men and women, with the effects being higher in men. Moreover, among men a critical pattern of coping with work stress enhanced the reported effect. In conclusion, the preliminary evidence from this study indicates an elevated risk of poor subjective health among freelance workers who are exposed to adverse psychosocial work conditions.