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Dive into the research topics where Philip R. Hamann is active.

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Featured researches published by Philip R. Hamann.


Tetrahedron Letters | 1989

Reactions of the trisulfide moiety in calicheamicin

G. A. Ellestad; Philip R. Hamann; Nada Zein; George O. Morton; Marshall M. Siegel; Michael J Pastel; Donald B. Borders; William J. McGahren

Abstract Calicheamicin γ1I ( 1 ) reacts with Ph3P to form a dimeric trisulfide ( 3 ), MeSSMe, Ph3PS, and Ph3PO, as well as an aromatic degradation product ( 2 ). The oxygen of the Ph3PO is derived from O2. Calicheamicin also reacts with thiols to produce disulfides (eg. 4 ) with high selectivity. Dimeric trisulfide 3 is generated during this reaction.


Synthetic Communications | 1989

The Efficient Synthesis of Two Prostaglandin Intermediates

Philip R. Hamann; Allan Wissner

Abstract This paper presents new synthetic routes for methyl cis-7-iodo-5-heptenoate (7) and 3-hydroxycyclopent-2-enone (15a), useful intermediates in the synthesis of prostanoids.


Archive | 1996

METHODS FOR THE PREPARATION OF MONOMERIC CALICHEAMICIN DERIVATIVE/CARRIER CONJUGATES

Martin P. Kunstmann; Irwin Hollander; Philip R. Hamann; Arthur Kunz


Archive | 1995

Conjugates of methyltrithio antitumor agents and intermediates for their synthesis

Philip R. Hamann; Lois Hinman; Irwin Hollander; Ryan Holcomb; William Hallett; Hwei-Ru Tsou; Martin J. Weiss


Archive | 1995

Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates

Martin P. Kuntsmann; Irwin Hollander; Philip R. Hamann


Archive | 1995

Enediyne derivatives useful for the synthesis of conjugates of methyltrithio antitumor agents

Philip R. Hamann; Lois Hinman; Irwin Hollander; Ryan Holcomb; William Hallett; Hwei-Ru Tsou; Martin J. Weiss


Archive | 1995

Process for preparing conjugates of methyltrithio antitumor agents

Philip R. Hamann; Lois Hinman; Irwin Hollander; Ryan Holcomb; William Hallett; Hwei-Ru Tsou; Martin J. Weiss


Archive | 1995

Linkers useful for the synthesis of conjugates of methyltrithio antitumor agents

Philip R. Hamann; Lois Hinman; Irwin Hollander; Ryan Holcomb; William Hallett; Hwei-Ru Tsou; Martin J. Weiss


Archive | 1994

Process for preparing targeted forms of methyltrithio antitumor agents

William J. McGahren; Martin Leon Sassiver; G. A. Ellestad; Philip R. Hamann; Lois Hinman; Janis Upeslacis


Archive | 1989

Targeted forms of methyltrithio antitumor agents

G. A. Ellestad; William J. McGahren; Martin Leon Sassiver; Philip R. Hamann; Lois Hinman; Janis Upeslacis

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