Philippe Maury

Are Women with Severely Symptomatic Brugada Syndrome Different from Men

Introduction: Spontaneous type‐1 ECG has been recognized as a risk factor for sudden cardiac death (SCD) in Brugada syndrome (BrS), but studied populations predominantly consisted of men. We sought to investigate whether a spontaneous type‐1 ECG pattern was also associated in women with severely symptomatic BrS. Other known risk factors were also examined for gender specificity.

Arrhythmogenesis in the Developing Heart During Anoxia‐Reoxygenation and Hypothermia‐Rewarming: An In Vitro Model

Introduction: The spatio‐temporal pattern of arrhythmias in the embryonic/fetal heart subjected to a transient hypoxic or hypothermic stress remains to be established.

Electrical storm in short-QT syndrome successfully treated with Isoproterenol.

Short‐QT Syndrome.u2003A 28‐year‐old man was admitted after aborted sudden cardiac death while sleeping. QTc was 320 ms, suggesting short‐QT syndrome (SQTS). The patient then presented with electrical storm with 8 successive episodes of ventricular fibrillation while on deep sedation and hypothermia. Isoproterenol infusion was introduced, leading to rapid cessation of any arrhythmic event. Isoproterenol can be effective in managing electrical storm in patients with SQTS. (J Cardiovasc Electrophysiol, Vol. 23, pp. 1028‐1030, September 2012)

Transient ST Elevation After Ketamine Intoxication: A New Cause of Acquired Brugada ECG Pattern

Brugada Syndrome and Ketamine Overdose.u2002 A 31‐year‐old man was referred for ketamine overdose. He presented initially with transient major Brugada ECG pattern. Complete investigation led to the diagnosis of slowly resolvent toxic myocarditis. Brugada‐like ECG was suspected to be caused by the ketamine intoxication in this case. (J Cardiovasc Electrophysiol, Vol. 22, pp. 91‐94, January 2011)

Effect of chronic amiodarone therapy on excitable gap during typical human atrial flutter.

Introduction: Class I antiarrhythmic drugs increase duration of the excitable gap (EG) during typical atrial flutter whereas intravenous class III drugs decrease the EG. The effect of chronic oral amiodarone therapy on the EG is unknown.

Short‐Term Heparin Kinetics during Catheter Ablation of Atrial Fibrillation

Percutaneous catheter ablation of atrial fibrillation (CA‐AF) is a treatment option for symptomatic drug‐refractory atrial fibrillation (AF). CA‐AF carries a risk for thromboembolic complications that has been minimized by the use of intraprocedural intravenous unfractionated heparin (UFH). The optimal administration of UFH as well as its kinetics are not well established and need to be precisely determined.

Detection of T‐Wave Beat‐By‐Beat Variations prior to Ventricular Arrhythmias Onset in ICD‐Stored Intracardiac Electrograms: The Endocardial T‐Wave Alternans Study (ETWAS)

The aim of the Endocardial T‐Wave Alternans Study was to prospectively assess the presence of T‐wave alternans (TWA) or beat‐to‐beat repolarization changes on implantable cardioverter‐defibrillator (ICD)‐stored electrograms (EGMs) immediately preceding the onset of spontaneous ventricular tachycardia (VT) or fibrillation (VF).

Lack of Correlations between Electrophysiological and Anatomical‐Mechanical Atrial Remodeling in Patients with Atrial Fibrillation

Atrial fibrillation (AF) progressively leads to electrical remodeling (ER) and anatomical‐mechanical remodeling (AR), whose relationships in humans remain poorly known.

Transseptal Implantation of a Left Ventricular Pacing Lead for an Ectopic Location of the Coronary Sinus Ostium in the Left Atrium

Congenital abnormalities of the coronary sinus (CS) are rare but can be responsible for unsuccessful implantation of a cardiac resynchronization therapy device. We report the case of an ectopic drainage of the CS in the left atrium. A left ventricular lead was implanted by the transseptal route. (PACE 2013; 36:e51–e52)

Microvolt T-Wave Alternans in Short QT Syndrome

Background: T‐wave alternans (TWA) is an accepted marker of risk for malignant ventricular arrhythmias, for which prognosis value has been established in different populations. Short QT syndrome (SQTS) is a very rare primary electrical disease carrying the risk of ventricular fibrillation. TWA in SQTS has not been evaluated yet.