Pierre Broto

SAR and X-ray. A New Approach Combining Fragment-Based Screening and Rational Drug Design: Application to the Discovery of Nanomolar Inhibitors of Src SH2

Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.

Principles governing the binding of a class of non-peptidic inhibitors to the SH2 domain of src studied by X-ray analysis

Hexahydropyridazine-3-carboxylic acid hydrazide and hydrazone derivatives, combinatorial libraries containing same, pharmaceutical compositions containing same and methods of preparation

DERIVADOS DE PIRIDAZINA, SUA UTILIZACAO COMO MEDICAMENTOS E SEU PROCESSO DE PREPARACAO

Pyridazinderivate, deren verwendung als heilmittel, und deren verfahren zu ihrer verwendung Pyridazine derivatives, their use as therapeutic agents, and their methods for their use

Pyridazine derivatives, their use as a remedy, and their methods for their use

Pyridazinderivate, deren verwendung als heilmittel, und deren verfahren zu ihrer verwendung Pyridazine derivatives, whose use as a remedy, and their methods for their use

Novel hexahydro-pyridazine-3-carbocylic acid hydrazide or hydrazone derivatives, combinatorial libraries containing same, use thereof as medicines, pharmaceutical compositions containing same and methods for preparing same

PYRIDAZINE DERIVATIVES, USE OF THE SAME AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND METHOD FOR PRODUCING THE SAME