Didier Benard | Researchain

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Featured researches published by Didier Benard.

Journal of Medicinal Chemistry | 2002

SAR and X-ray. A New Approach Combining Fragment-Based Screening and Rational Drug Design: Application to the Discovery of Nanomolar Inhibitors of Src SH2

Dominique Lesuisse; Gudrun Lange; Pierre Deprez; Didier Benard; Bernard Schoot; Georges Delettre; Jean-Pierre Marquette; Pierre Broto; Véronique Jean-Baptiste; Paulette Bichet; Edoardo Sarubbi; Eliane Mandine

Journal of Medicinal Chemistry | 2003

Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.

Gudrun Lange; Dominique Lesuisse; Pierre Deprez; Bernard Schoot; Petra Loenze; Didier Benard; Jean-Pierre Marquette; Pierre Broto; Edoardo Sarubbi; Eliane Mandine

Archive | 2007

Cyclic Urea Derivatives, Preparation Thereof And Pharmaceutical Use Thereof As Kinase Inhibitors

Hartmut Strobel; Sven Ruf; Dominique Lesuisse; Conception Nemecek; Youssef El-Ahmad; Stefan Guessregen; Anne Lebrun; Kurt Ritter; Didier Benard; Augustin Hittinger; Herve Bouchard

Archive | 2006

Fluorene derivatives, composition containing said derivatives and the use thereof

Patrick Mailliet; Luc Bertin; Fabienne Thompson; Jean-Marie Ruxer; Fabienne Pilorge; Didier Benard; Hervé Minoux; Chantal Carrez; Hélène Goulaouic; Thierry Gouyon

Archive | 2004

Cyclic urea derivatives, preparation method thereof and pharmaceutical use of same as kinase inhibitors

Marcel Patek; Anil Nair; Augustin Hittinger; Conception Nemecek; Daniel Bond; Greg Harlow; Herve Bouchard; Jacques Mauger; Jean-Luc Malleron; Mark G. Palermo; Fahad Al-Obeidi; Thomas Faitg; Hartmut Strobel; Sven Ruf; Kurt Ritter; Youssef El-Ahmad; Dominique Lesuisse; Didier Benard

Journal of Medicinal Chemistry | 2002

Principles governing the binding of a class of non-peptidic inhibitors to the SH2 domain of src studied by X-ray analysis

Gudrun Lange; Dominique Lesuisse; Pierre Deprez; Bernard Schoot; Petra Loenze; Didier Benard; Jean-Pierre Marquette; Pierre Broto; Edoardo Sarubbi; Eliane Mandine

Biochemical and Biophysical Research Communications | 2002

High-affinity Src-SH2 ligands which do not activate Tyr527-phosphorylated Src in an experimental in vivo system

Eliane Mandine; Véronique Jean-Baptiste; Béatrice Vayssière; Dominique Gofflo; Didier Benard; Edoardo Sarubbi; Pierre Deprez; Roland Baron; Giulio Superti-Furga; Dominique Lesuisse

Archive | 2006